1988
Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis
Chofflon M, Weiner H, Morimoto C, Hafler D. Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis. Annals Of Neurology 1988, 24: 185-191. PMID: 2972249, DOI: 10.1002/ana.410240203.Peer-Reviewed Original ResearchConceptsSuppressor-inducer T cellsProgressive multiple sclerosisInducer T cellsSuppressor T cellsMultiple sclerosisT cellsFunctional suppressionTwo-color immunofluorescenceImmunoregulatory abnormalitiesImmunological findingsIgG synthesisMononuclear cellsPokeweed mitogenImmunoglobulin synthesisNormal subjectsSclerosisCD4Neurological diseasesAMLRPatientsTwo-stage assaySuppressor functionSignificant correlationPresent studyCells
1985
Decreased autologous mixed lymphocyte reaction in multiple sclerosis
Hafler D, Buchsbaum M, Weiner H. Decreased autologous mixed lymphocyte reaction in multiple sclerosis. Journal Of Neuroimmunology 1985, 9: 339-347. PMID: 2931449, DOI: 10.1016/s0165-5728(85)80034-5.Peer-Reviewed Original ResearchConceptsT4/T8 ratioHigh T4/T8 ratioT8 ratioMultiple sclerosisNormal controlsInactive patientsActive diseaseMS patientsAutologous mixed lymphocyte reactionActive MS patientsSubgroup of patientsT cell responsesT cell subsetsMultiple sclerosis patientsT4/T8Mixed lymphocyte reactionCentral nervous systemSclerosis patientsLymphocyte reactionAutoimmune diseasesT cellsPatientsNervous systemViral disordersAMLR