2019
Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses
Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses. Schizophrenia Research 2019, 217: 124-135. PMID: 31391148, PMCID: PMC6997041, DOI: 10.1016/j.schres.2019.07.036.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderGene Expression ProfilingHumansPsychotic DisordersSchizophreniaTranscriptomeConceptsGene modulesSZ casesGene co-expression network analysisCo-expression network analysisGene expression profilesGene expression alterationsChromatin regulationChromatin remodelingNineteen genesGene networksTranscriptomic abnormalitiesDisorder-specific changesGene expressionExpression profilesBiological processesImmune signalingExpression alterationsTranscriptomic signaturesGenesReactive oxygenUnaffected comparison subjectsMajor psychosesOxidative stressBD casesApoptosis
2017
PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma
Breen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ. PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. Neuropsychopharmacology 2017, 43: 469-481. PMID: 28925389, PMCID: PMC5770765, DOI: 10.1038/npp.2017.220.Peer-Reviewed Original ResearchConceptsDistinct gene expression perturbationsCo-expression network analysisMitogen-activated protein kinase activityCommon signaling cascadesGene expression perturbationsProtein kinase activityTranscriptome-wide screenDistinct biological pathwaysMolecular convergenceGene expression signaturesTranscriptome studiesExpression perturbationsTranscriptional dysregulationSignaling cascadesKinase activityBiological pathwaysExpression signaturesType I interferonWidespread immune dysregulationInnate immuneLipid metabolismPathwayI interferonNetwork analysisDysregulation
2016
Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined‐samples mega‐analysis
Tylee DS, Hess JL, Quinn TP, Barve R, Huang H, Zhang‐James Y, Chang J, Stamova BS, Sharp FR, Hertz‐Picciotto I, Faraone SV, Kong SW, Glatt SJ. Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined‐samples mega‐analysis. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 181-201. PMID: 27862943, PMCID: PMC5499528, DOI: 10.1002/ajmg.b.32511.Peer-Reviewed Original ResearchRNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects
Tylee DS, Espinoza AJ, Hess JL, Tahir MA, McCoy SY, Rim JK, Dhimal T, Cohen OS, Glatt SJ. RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects. Autism Research 2016, 10: 439-455. PMID: 27529825, DOI: 10.1002/aur.1679.Peer-Reviewed Original ResearchConceptsTranscriptomic differencesGenome-wide expression studiesGene co-expression network analysisCo-expression network analysisTranscriptomic signaturesGene-set analysisStructural genetic variantsIdentified transcriptsGenomic studiesExpression studiesLymphoblastoid cell linesGenetic variantsCell linesExpression valuesNetwork analysisSignificant overlapGenesTranscriptsRNAASD studiesAutism spectrum disorderMale samplesLarge numberSignaturesFemalesTranscriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia
Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia. Schizophrenia Research 2016, 176: 114-124. PMID: 27450777, PMCID: PMC5026943, DOI: 10.1016/j.schres.2016.07.006.Peer-Reviewed Original ResearchConceptsGene co-expression modulesMicroarray dataCo-expression modulesInnate immune gene expressionRelated gene setsImmune gene expressionTranscription regulatorsNetwork-based analysisGene setsBiological functionsGene expressionRegulatory factorsPostmortem prefrontal cortexMicroarray technologyCell typesTop hitsHigh-throughput assessmentGenesTissue functionBlood tissuePostmortem brain tissueGenetic risk factorsImmunologic genesMicroarray literatureDysregulation
2013
On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”
Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 595-603. PMID: 24132893, DOI: 10.1002/ajmg.b.32150.Peer-Reviewed Original ResearchConceptsCpG island methylation levelsCross-tissue correlationBlood-based biomarker studiesTranscriptomic studiesDNA methylationOmics analysisGene expressionMethylation levelsBlood tissue samplesExpression levelsProtein expressionProfiling methodExpressionEpigenomeTranscriptomeProteomeGenesMethylationTranscriptsTissue samplesValidation of biomarkersBetter understandingCritical precursorPatternsParticular subset