2022
Identification and functional implications of pseudouridine RNA modification on small noncoding RNAs in the mammalian pathogen Trypanosoma brucei
Rajan KS, Adler K, Doniger T, Cohen-Chalamish S, Aharon-Hefetz N, Aryal S, Pilpel Y, Tschudi C, Unger R, Michaeli S. Identification and functional implications of pseudouridine RNA modification on small noncoding RNAs in the mammalian pathogen Trypanosoma brucei. Journal Of Biological Chemistry 2022, 298: 102141. PMID: 35714765, PMCID: PMC9283944, DOI: 10.1016/j.jbc.2022.102141.Peer-Reviewed Original ResearchConceptsRNA modificationsLife stagesStage-specific regulationGenome-wide approachesSmall nucleolar RNAsΨ modificationsSmall noncoding RNAsDifferent host environmentsProtein translocationD snoRNAsRRNA modificationVault RNARRNA processingNucleolar RNAsRiboMeth-seqNoncoding RNAsMammalian hostsTrypanosoma bruceiProtein synthesisHost environmentRNAFunctional implicationsTRNABruceiParasites
2019
Small nucleolar RNAs controlling rRNA processing in Trypanosoma brucei
Chikne V, Rajan K, Shalev-Benami M, Decker K, Cohen-Chalamish S, Madmoni H, Biswas VK, Gupta S, Doniger T, Unger R, Tschudi C, Ullu E, Michaeli S. Small nucleolar RNAs controlling rRNA processing in Trypanosoma brucei. Nucleic Acids Research 2019, 47: 2609-2629. PMID: 30605535, PMCID: PMC6411936, DOI: 10.1093/nar/gky1287.Peer-Reviewed Original ResearchConceptsSmall nucleolar RNAsRRNA processingNucleolar RNAsLarge subunit ribosomal RNAProtein exit tunnelMost eukaryotesRRNA modificationBiogenesis stepsRRNA transcriptionExit tunnelRibosomal RNARRNA precursorRNA piecesSnoRNAsProcessing eventsRRNA positionsMaturation eventsRNAGuide modificationsEukaryotesLSURRNATranscriptionHigher number