2018
Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
Cooper C, Silkstone G, Simons M, Rajagopal B, Syrett N, Shaik T, Gretton S, Welbourn E, Bülow L, Eriksson N, Ronda L, Mozzarelli A, Eke A, Mathe D, Reeder B. Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute. Free Radical Biology And Medicine 2018, 134: 106-118. PMID: 30594736, PMCID: PMC6597946, DOI: 10.1016/j.freeradbiomed.2018.12.030.Peer-Reviewed Original ResearchConceptsTyrosine residuesΒ-subunitSingle tyrosine mutationsFerryl heme speciesOxidative stressExtracellular proteinsTyrosine mutationWild typePromising mutantsHEK cellsProtein surfaceHeme speciesMutationsMembrane damageRedox-active tyrosine residueHeme reductionOxidative toxicityFerryl speciesFerric HbSubunitsHb additionHeme lossSpeciesProteinFerric form
2009
Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics
Herman P, Kocsis L, Eke A. Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics. Methods In Molecular Biology 2009, 489: 23-40. PMID: 18839086, DOI: 10.1007/978-1-59745-543-5_2.Peer-Reviewed Original ResearchConceptsCerebral hemodynamicsBrain cortexRat brain cortexLaser Doppler flowmetryAge-related stiffeningFunctional magnetic resonanceHemodynamic brain signalsDoppler flowmetryCerebral vasculatureTemporal lobeHuman studiesState of pathologyGray matterParenchymal regionsHemodynamic signalsHemodynamicsHuman brainCortexMagnetic resonanceMedical significance
2006
Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge
Herman P, Eke A. Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1189-1197. PMID: 16395288, DOI: 10.1038/sj.jcbfm.9600266.Peer-Reviewed Original Research
2001
Fractal Branching Pattern in the Pial Vasculature in the Cat
Hermán P, Kocsis L, Eke A. Fractal Branching Pattern in the Pial Vasculature in the Cat. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 741-753. PMID: 11488543, DOI: 10.1097/00004647-200106000-00012.Peer-Reviewed Original Research
2000
Physiological time series: distinguishing fractal noises from motions
Eke A, Hermán P, Bassingthwaighte J, Raymond G, Percival D, Cannon M, Balla I, Ikrényi C. Physiological time series: distinguishing fractal noises from motions. Pflügers Archiv - European Journal Of Physiology 2000, 439: 403-415. PMID: 10678736, DOI: 10.1007/s004249900135.Peer-Reviewed Original Research
1997
Temporal Fluctuations in Regional Red Blood Cell Flux in the Rat Brain Cortex is a Fractal Process
Eke A, Herman P, Bassingthwaighte J, Raymond G, Balla I, Ikrényi C. Temporal Fluctuations in Regional Red Blood Cell Flux in the Rat Brain Cortex is a Fractal Process. Advances In Experimental Medicine And Biology 1997, 428: 703-709. PMID: 9500118, PMCID: PMC4121065, DOI: 10.1007/978-1-4615-5399-1_98.Peer-Reviewed Original Research
1994
Light Intensity Attenuation in the Rat Brain Tissue Assessed by Television Photometry
Eke A, Ikrényi C, Sárváry E. Light Intensity Attenuation in the Rat Brain Tissue Assessed by Television Photometry. Advances In Experimental Medicine And Biology 1994, 345: 643-650. PMID: 8079768, DOI: 10.1007/978-1-4615-2468-7_85.Peer-Reviewed Original ResearchConceptsWavelength rangeTime-resolved spectroscopyVisible wavelength rangeShort wavelength rangeLight intensity attenuationDirect measurementOptical pathlengthAttenuation of lightOptical approachPhoton migrationNear-Infrared LightOptical imagingAbsolute measurementsReflectometric measurementsInfrared lightIntensity attenuationNon-destructive natureLight attenuation profilesSignal contributionsAttenuation profilesTemporal resolutionMeasurementsMultiparametric imagingPhotonsLight penetration
1993
A mathematical model of the intracerebral steal phenomenon in regional and focal ischaemia
Hudetz A, Conger K, Eke A, Halsey J. A mathematical model of the intracerebral steal phenomenon in regional and focal ischaemia. Neurological Research 1993, 15: 117-127. PMID: 8099206, DOI: 10.1080/01616412.1993.11740121.Peer-Reviewed Original ResearchMultiparametric Imaging of Microregional Circulation over the Brain Cortex by Videoreflectometry
Eke A. Multiparametric Imaging of Microregional Circulation over the Brain Cortex by Videoreflectometry. Advances In Experimental Medicine And Biology 1993, 333: 183-191. PMID: 8362659, DOI: 10.1007/978-1-4899-2468-1_16.Peer-Reviewed Original ResearchConceptsBlood flowBrain cortexTissue microcirculationLevel of microcirculationMultiparametric imagingNutritive microcirculationParenchymal circulationMean transit timeBlood volumeMultiparametric assessmentMicrocirculationPlasma volumeRepeatable mannerSpatial resolutionTissue elementsFlowVolume flowCapillary networkCortexErythrocytesDiameter of capillariesTransit time
1992
Instrumentation and Technology for Multiparametric Mapping of Intraparenchymal Circulation in the Brain Cortex
Eke A. Instrumentation and Technology for Multiparametric Mapping of Intraparenchymal Circulation in the Brain Cortex. Advances In Experimental Medicine And Biology 1992, 317: 671-678. PMID: 1288187, DOI: 10.1007/978-1-4615-3428-0_80.Peer-Reviewed Original ResearchConceptsBrain cortexSpatial resolutionRepeatable mannerVolume flowEnergy balanceSpatial imagingTechnologyMean transit timeInstrumentationBlood volumeLevel of instrumentationMultiparametric assessmentDischarge hematocritResolution mapsPlasma volumeCapillary bedHigh-resolution mapsCortexMultiparametric mappingMm2
1990
Histologic assessment of neurons in rat models of cerebral ischemia.
Eke A, Conger K, Anderson M, Garcia J. Histologic assessment of neurons in rat models of cerebral ischemia. Stroke 1990, 21: 299-304. PMID: 2305408, DOI: 10.1161/01.str.21.2.299.Peer-Reviewed Original Research
1989
Classifying cells from light microscopic bit features by binary logic. Application to grade neuronal injury in cerebral ischemia.
Eke A, Conger K. Classifying cells from light microscopic bit features by binary logic. Application to grade neuronal injury in cerebral ischemia. Laboratory Investigation 1989, 61: 243-52. PMID: 2755081.Peer-Reviewed Original ResearchHematocrit Changes in the Extra- and Intraparenchymal Circulation of the Feline Brain Cortex in the Course of Global Cerebral Ischemia
Eke A. Hematocrit Changes in the Extra- and Intraparenchymal Circulation of the Feline Brain Cortex in the Course of Global Cerebral Ischemia. Advances In Experimental Medicine And Biology 1989, 248: 439-449. PMID: 2782165, DOI: 10.1007/978-1-4684-5643-1_49.Peer-Reviewed Original ResearchConceptsGlobal cerebral ischemiaCerebral ischemiaTissue hematocritMean arterial blood pressureArterial blood pressureIschemic tissue damageCerebrocortical tissueParenchymal circulationBlood pressureArterial hemorrhageBrain cortexIschemic conditionsAltered distribution patternHematocrit changesTissue damageFocal alterationsSignificant heterogeneityIschemiaHematocritControl conditionPresent studyPreliminary studyHemorrhageMicrocirculationCortex
1987
Imaging of Red Blood Cell and Plasma Dispersion in the Brain Cortex
Eke A. Imaging of Red Blood Cell and Plasma Dispersion in the Brain Cortex. Advances In Experimental Medicine And Biology 1987, 215: 21-27. PMID: 3314402, DOI: 10.1007/978-1-4684-7433-6_3.Peer-Reviewed Original Research
1985
Distribution of Cerebrocortical Microflow in Norma- and Hypertensive Rats: Studies in Ischemia
Eke A, Halsey J. Distribution of Cerebrocortical Microflow in Norma- and Hypertensive Rats: Studies in Ischemia. Advances In Experimental Medicine And Biology 1985, 191: 107-109. PMID: 3832836, DOI: 10.1007/978-1-4684-3291-6_10.Peer-Reviewed Original ResearchRedistribution of Cerebrocortical Microflow During Increased Neuronal Activity
Eke A. Redistribution of Cerebrocortical Microflow During Increased Neuronal Activity. Advances In Experimental Medicine And Biology 1985, 191: 101-105. PMID: 3832835, DOI: 10.1007/978-1-4684-3291-6_9.Peer-Reviewed Original Research
1984
Distribution of Cerebrocortical Microflow in Normo- and Hypertensive Rats
Eke A, Halsey J. Distribution of Cerebrocortical Microflow in Normo- and Hypertensive Rats. Advances In Experimental Medicine And Biology 1984, 180: 203-210. PMID: 6534100, DOI: 10.1007/978-1-4684-4895-5_19.Peer-Reviewed Original ResearchConceptsHypertensive brainHypertensive ratsCirculatory adaptationBilateral carotid ligationTransient ischemic episodesNormotensive animalsCarotid ligationVascular caliberIschemic episodesBlood flowIntraparenchymal distributionBlood contentCerebrocortical microflowRatsBrainNormotensiveIschemiaRCBFNormo
1982
Reflectometric Mapping of Microregional Blood Flow and Blood Volume in the Brain Cortex
Eke A. Reflectometric Mapping of Microregional Blood Flow and Blood Volume in the Brain Cortex. Cerebrovascular And Brain Metabolism Reviews 1982, 2: 41-53. PMID: 6801064, DOI: 10.1038/jcbfm.1982.5.Peer-Reviewed Original Research
1981
Stability of Oxygen Transmissibility During Ischemia
Eke A, Strong E, Halsey J. Stability of Oxygen Transmissibility During Ischemia. Neurological Research 1981, 3: 211-228. PMID: 6122173, DOI: 10.1080/01616412.1981.11739599.Peer-Reviewed Original Research
1979
Induced hemodilution detected by reflectometry for measuring microregional blood flow and blood volume in cat brain cortex
Eke A, Hutiray G, Kovách A. Induced hemodilution detected by reflectometry for measuring microregional blood flow and blood volume in cat brain cortex. American Journal Of Physiology 1979, 236: h759-h768. PMID: 375750, DOI: 10.1152/ajpheart.1979.236.5.h759.Peer-Reviewed Original Research