2024
Validation of biomarkers of aging
Moqri M, Herzog C, Poganik J, Ying K, Justice J, Belsky D, Higgins-Chen A, Chen B, Cohen A, Fuellen G, Hägg S, Marioni R, Widschwendter M, Fortney K, Fedichev P, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel D, Kennedy B, Cummings S, Slagboom P, Verdin E, Maier A, Sebastiano V, Snyder M, Gladyshev V, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nature Medicine 2024, 30: 360-372. PMID: 38355974, PMCID: PMC11090477, DOI: 10.1038/s41591-023-02784-9.Peer-Reviewed Original Research
2023
Biomarkers of aging for the identification and evaluation of longevity interventions
Moqri, Herzog C, Poganik J, Consortium B, Justice J, Belsky D, Higgins-Chen A, Moskalev A, Fuellen G, Cohen A, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han J, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy B, Ferrucci L, Horvath S, Verdin E, Maier A, Snyder M, Sebastiano V, Gladyshev V. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell 2023, 186: 3758-3775. PMID: 37657418, PMCID: PMC11088934, DOI: 10.1016/j.cell.2023.08.003.Peer-Reviewed Original ResearchOxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Sturm G, Karan K, Monzel A, Santhanam B, Taivassalo T, Bris C, Ware S, Cross M, Towheed A, Higgins-Chen A, McManus M, Cardenas A, Lin J, Epel E, Rahman S, Vissing J, Grassi B, Levine M, Horvath S, Haller R, Lenaers G, Wallace D, St-Onge M, Tavazoie S, Procaccio V, Kaufman B, Seifert E, Hirano M, Picard M. OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology 2023, 6: 22. PMID: 36635485, PMCID: PMC9837150, DOI: 10.1038/s42003-022-04303-x.Peer-Reviewed Original ResearchMeSH KeywordsDNA, MitochondrialHumansLongevityMitochondriaMitochondrial DiseasesOxidative PhosphorylationConceptsIntegrated stress responseOXPHOS defectsMitochondrial diseaseCellular energy expenditureMitochondrial DNA instabilityPatient-derived fibroblastsMitochondrial oxidative phosphorylationCell divisionExtracellular secretionOxidative phosphorylationStress responseDNA instabilityMechanistic basisEnergetic costEpigenetic agingGeneral mechanismOXPHOSBiological agingExcess energy expenditurePotential mechanismsEnergy expenditureCellsMulti-system disorderMetabokinesRNAseq