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David A. Alagpulinsa, PhD

Assistant Professor

Contact Information

David A. Alagpulinsa, PhD

Research Summary

Our research program is still burgeoning and primarily focuses on metabolic diseases, with particular emphasis on type 1 diabetes (T1D) and atherosclerotic cardiovascular disease (ASCVD). The etiopathogenesis of T1D is characterized by a detrimental cross-talk between the hematopoietic system and insulin-producing beta cells. There is also evidence that T1D is intrinsically linked with ASCVD above and beyond traditional cardiovascular risk factors, such as hyperglycemia and dyslipidemia. In that vein, our research ideology is that there may be a genetic link between T1D and ASCVD independent of beta-cell demise and a definitive prevention or cure for T1D may require elimination of both insulin dependence and cardiovascular disease risk, at least, in some patients. We employ a combination of human statistical genetics and genomics, cellular and molecular/biochemical assays, and animal models to understand the pathological mechanisms in the hematopoietic system, beta cells, and the cardiovascular system, and how these are connected in T1D. Our exit plan is to identify and validate disease biomarkers for prediction, precision medicine, and preclinical translation that would facilitate transition to the bedside.

Research Interests

Autoimmune Diseases; Cardiovascular Diseases; Diabetes Mellitus, Type 1; DNA Transposable Elements; Genetics; Hematopoiesis; Hematopoietic Stem Cells; Islets of Langerhans; Myocardial Infarction; Genomics; Atherosclerosis; Epigenomics; Single-Cell Analysis; Clonal Hematopoiesis

Selected Publications