Alagpulinsa Laboratory (The AlagsLab)

The AlagsLab is an interdisciplinary research group dedicated to understanding how hematopoietic function shapes human health and disease. Our research investigates the hematopoietic system as a central biological conduit through which genetic variation influences multiple complex traits and diseases, providing mechanistic insights into genetic pleiotropy across organ systems.

Our primary disease focus is autoimmune disease, particularly type 1 diabetes (T1D), which serves as a model for understanding how hematopoietic function contributes to neuroimmune interactions, disease susceptibility, and long-term outcomes. By studying the dynamic interplay between hematopoietic function and diverse physiological systems, we seek to uncover shared mechanisms that explain disease comorbidity, resilience, and therapeutic response.

We integrate population-scale human genetics, molecular and statistical genetics, immunobiology, pharmacology, bioengineering, multi-omic technologies, and functional experimental models to define the molecular and cellular mechanisms linking hematopoietic biology to human health and disease. We translate these discoveries into biomarkers, therapeutic targets, and precision medicine strategies with the potential to benefit multiple diseases simultaneously.

Equally central to our mission is training the next generation of scientists. We foster a rigorous, collaborative, and intellectually inclusive environment where curiosity, creativity, and cross-disciplinary thinking drive discovery. We strive to equip trainees with the scientific rigor, independence, and interdisciplinary perspective needed to address fundamental questions in human biology and develop innovative solutions for complex diseases.