2025
Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking
Wemm S, Holzhauer C, Harrison L, Milivojevic V, Fogelman N, Cao Z, Wulfert E. Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking. Psychoneuroendocrinology 2025, 177: 107469. PMID: 40250213, PMCID: PMC12131328, DOI: 10.1016/j.psyneuen.2025.107469.Peer-Reviewed Original ResearchConceptsTrier Social Stress TestHypothalamic-pituitary-adrenal axisAxis responseProblem gamblingPathophysiology of addictive disordersHPA axis responseSocial Stress TestHypothalamic-pituitary-gonadal axisHealthy control participantsLaboratory-induced stressStress-related changesStress hormone cortisolHypothalamic-pituitary-gonadal axis hormonesAddictive disordersAddiction mechanismsLaboratory stressorSubstance addictionControl participantsNeuroactive steroidsNeuroendocrine responsesAttenuated cortisolPsychological featuresProblem gamblersHormone cortisolGambling
2009
Prenatal stress and the programming of the HPA axis
Glover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisPrenatal stressLong-term effectsIndependent prospective studiesHPA axis responseBasal cortisol levelsProspective studyAxis responseAnimal studiesCognitive alterationsCortisol responseCortisol levelsCognitive outcomesOutcomesRecent studiesGenetic strainsChildrenLittle evidenceOffspringGestationStudy
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse
2003
Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
1995
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartum
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