2023
Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Picci G, Casagrande C, Ott L, Petro N, Christopher‐Hayes N, Johnson H, Willett M, Okelberry H, Wang Y, Stephen J, Calhoun V, Wilson T. Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping 2023, 44: 6388-6398. PMID: 37853842, PMCID: PMC10681633, DOI: 10.1002/hbm.26516.Peer-Reviewed Original ResearchConceptsTrauma-related symptomsAnxiety symptomsPituitary volumeAnterior pituitary volumeConsistent with adult findingsHigh-resolution T1-weighted MRI scansPG volumeEarly life stressLevels of dehydroepiandrosteroneT1-weighted MRI scansDehydroepiandrosterone levelsPituitary glandResponse to stressComorbid anxietyNeurobiological sequelaeSubclinical anxietyLife stressAnxiety/depression symptomsElevated anxietyAdult findingsAssociated with disruptionDevelopmental sampleHealthy youthTrained ratersPubertal window
2013
Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
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