2022
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs
Wiley K, Camilo C, Gouveia G, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother–infant pairs. Developmental Psychobiology 2022, 65: e22352. PMID: 36567654, PMCID: PMC9792831, DOI: 10.1002/dev.22352.Peer-Reviewed Original ResearchConceptsPrenatal psychological distressLate pregnancyMaternal prenatal psychosocial stressMaternal hair cortisolMaternal prenatal psychological distressPrenatal psychosocial stressPsychological distressAdrenal axis functionInfants of mothersEvening salivary cortisolMother-infant pairsInfant DNA methylationMultivariable linear regressionHair cortisol concentrationsElevated anxiety symptomsAxis functionFetal programingEvening cortisolPregnant adolescentsMaternal distressPsychosocial stressCortisol concentrationsPregnancyHair cortisolSalivary cortisol
2020
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2001
Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report
Jacobsen L, Giedd J, Kreek M, Gottschalk C, Kosten T. Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. Drug And Alcohol Dependence 2001, 62: 49-56. PMID: 11173167, DOI: 10.1016/s0376-8716(00)00159-9.Peer-Reviewed Original ResearchConceptsTotal brain volumeAdrenocorticotropin hormoneMagnetic resonance imagingCocaine dependenceHealthy subjectsHippocampal damageBrain volumeCortisol levelsAdrenal axis functionChronic cocaine dependenceCocaine-dependent subjectsCocaine-dependent patientsDays of abstinenceDirect toxic effectMedial temporal lobeAxis functionChronic elevationDependent patientsClinical studiesHippocampal neuronsTemporal lobeOvine corticotropinPlasma cortisolResonance imagingDependent subjects
1999
Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates
Weiss EL, Longhurst JG, Mazure CM. Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates. American Journal Of Psychiatry 1999, 156: 816-828. PMID: 10360118, DOI: 10.1176/ajp.156.6.816.Peer-Reviewed Original ResearchConceptsAdult-onset depressionChildhood sexual abuseEarly stressorsHPA axisSexual abuseAdrenal axis functionLong-term dysregulationMajor depressive disorderStress-induced dysregulationDepressive illnessAxis functionDepressed patientsDepressive disorderRisk factorsLong-term effectsHuman studiesManual searchNeurobiological correlatesPsychosocial mechanismsDepressionWomenEarly stressDysregulationSubsequent developmentDysregulation results
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