2020
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2016
Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies. 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.Peer-Reviewed Original ResearchAntidepressant activityPreclinical studiesAntidepressant actionKetamine's mechanismPreclinical literatureRodent modelsRapid onsetBrain-derived neurotrophic factor (BDNF) expressionBehavioral effectsClassic antidepressant drugsRapid antidepressant activityNeurotrophic factor expressionChronic stressor exposureReceptor-targeted drugsNovel drug developmentAntidepressant propertiesKetamine effectsClinical trialsAntidepressant drugsSynaptic plasticityReceptor activationClinical settingFactor expressionStressor exposureDurable effects
2015
Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet
Musumeci G, Castrogiovanni P, Castorina S, Imbesi R, Szychlinska M, Scuderi S, Loreto C, Giunta S. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain Research Bulletin 2015, 119: 12-18. PMID: 26444078, DOI: 10.1016/j.brainresbull.2015.09.010.Peer-Reviewed Original ResearchConceptsFrontal cortexHigh TrP dietDentate gyrusTrp dietBrain areasBrain-derived neurotrophic factor (BDNF) expressionBrain-derived neurotrophic factorHigh-tryptophan dietNeuroplasticity-related moleculesBDNF protein expressionNeurotrophic factor expressionHippocampal region CA1Normal aging processAge-related cognitive declineChronic dietDiet protectsTryptophan dietWestern blot analysisBDNF expressionBDNF increaseBDNF systemNeurotrophin levelsAge-related declineTrp intakeNeurotrophic factor
2001
ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment
Chen A, Shin K, Duman R, Sanacora G. ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment. Journal Of Ect 2001, 17: 27-32. PMID: 11281511, DOI: 10.1097/00124509-200103000-00006.Peer-Reviewed Original ResearchConceptsNeurotrophic factor expressionMossy fiber sproutingBDNF expressionElectroconvulsive seizuresKetamine pretreatmentSeizure durationFiber sproutingDentate gyrusBrain-derived neurotrophic factor (BDNF) expressionFactor expressionChronic electroconvulsive seizureSpecific anesthetic agentsTreatment of depressionNMDA receptor activationMossy fiber pathwayUse of ECTMedial prefrontal cortexTimm histochemistryCortical atrophySeizure intensitySeizure activityMajor depressionNMDA antagonistsNMDA receptorsAnesthetic agents
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