2025
CELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS
Wang *, Chen X, Tian Y, Yu Z, Chen D, Xiu M, Kosten T, Zhang X. CELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS. The International Journal Of Neuropsychopharmacology 2025, 28: i158-i159. PMCID: PMC11815116, DOI: 10.1093/ijnp/pyae059.274.Peer-Reviewed Original ResearchHamilton Depression Rating ScaleBrain-derived neurotrophic factorPositive and Negative Syndrome ScaleBrain-derived neurotrophic factor serum levelsBrain-derived neurotrophic factor levelsSchizophrenia patientsTreatment of depressionDepressive symptomsPositive symptomsFirst-episodeSCZ patientsHamilton Depression Rating Scale total scoreBrain-derived neurotrophic factor systemComorbid major depressive disorderTreatment response to antidepressantsTotal scoreEarly stages of schizophreniaBrain-derived neurotrophic factor polymorphismsBrain-derived neurotrophic factor genotypePathogenesis of depressive symptomsBrain-derived neurotrophic factor gene polymorphismImprove treatment of depressionBrain-derived neurotrophic factor signalingHealthy controlsAmerican Journal of Psychiatry
2024
Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
Matsuzaki K, Sugimoto N, Hossain S, Islam R, Sumiyoshi E, Hashimoto M, Kishi H, Shido O. Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats. Food & Function 2024, 15: 5579-5595. PMID: 38713055, DOI: 10.1039/d4fo00683f.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVesicular monoamine transporter-2Brain-derived neurotrophic factorPrefrontal cortexDopamine transporterCognitive functionDopamine concentrationTyrosine hydroxylaseADHD animal modelWistar-Kyoto ratsBrain-derived neurotrophic factor levelsWorking Memory DeficitsTB administrationY-maze taskCortex of spontaneously hypertensive ratsFrontal cortex of SHRADHD-like behaviorsOpen field testPotential adjunctive treatmentStroke-prone spontaneously hypertensive ratsWorking memoryAttention-deficit/hyperactivityMemory deficitsCognitive deficitsFrontal cortex
2023
Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients
Ng D, Cheng I, Wang C, Tan C, Toh Y, Koh Y, Ke Y, Foo K, Chan R, Ho H, Chew L, bin Harunal Rashid M, Chan A. Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients. Scientific Reports 2023, 13: 16298. PMID: 37770565, PMCID: PMC10539508, DOI: 10.1038/s41598-023-43581-1.Peer-Reviewed Original ResearchConceptsCancer-related cognitive impairmentYoung adult cancer patientsBrain-derived neurotrophic factorAdult cancer patientsCambridge Neuropsychological Test Automated BatteryCancer participantsNon-cancer controlsPlasma brain-derived neurotrophic factorSociodemographic variablesBDNF levelsCognitive impairmentBrain-derived neurotrophic factor Val66MetCancer patientsAssociated with worse attentionNeurotrophic factorBrain-derived neurotrophic factor levelsAssociated with enhanced executive functionBaseline BDNF levelsFACT-CogPlasma BDNF levelsPsychological distressImprove cognitive functionBaseline cognitionPost-baselineEnzyme-linked immunosorbent assay
2022
BDNF blood levels after electroconvulsive therapy in patients with mood disorders: An updated systematic review and meta-analysis
Pelosof R, dos Santos L, Farhat L, Gattaz W, Talib L, Brunoni A. BDNF blood levels after electroconvulsive therapy in patients with mood disorders: An updated systematic review and meta-analysis. The World Journal Of Biological Psychiatry 2022, 24: 24-33. PMID: 35332840, DOI: 10.1080/15622975.2022.2058083.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBrain-derived neurotrophic factor blood levelsBrain-derived neurotrophic factor levelsElectroconvulsive therapyMeta-analysisSystematic reviewBrain-derived neurotrophic factor changesRandom-effects meta-analysesTreatment of depressionDepression severity scoresElectroconvulsive therapy treatmentsSample sizeBlood levelsEvidence of significant heterogeneityDepressive symptomatologyMood disordersDepressive symptomsMeta-analysesMeta-RegressionGlobal healthNeurotrophic factorSignificant heterogeneitySubgroup analysisClinical trialsSeverity score
2021
The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2020
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2019
Self‐Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study
Spartano NL, Davis-Plourde KL, Himali JJ, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Self‐Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study. Journal Of Diabetes Research 2019, 2019: 2718465. PMID: 30729134, PMCID: PMC6343169, DOI: 10.1155/2019/2718465.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorIGF-1 levelsDiabetes mellitusAmbulatory physical activityPhysical activityIGF-1Neurotrophic factorBrain-derived neurotrophic factor levelsHigher IGF-1 levelsInsulin-like growth factor-1Self-reported physical activityExamination cycle 7Higher BDNF levelsNeurotrophic factor levelsHormone replacement therapyPrevalent cardiovascular diseaseTotal physical activityFramingham Offspring StudyGrowth factor-1Multivariable regression modelsPhysical activity variablesMore physical activityEndothelial growth factorMiddle-aged adultsLinear multivariable regression models
2016
Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis
Kim B, Lee S, Graham P, Angelucci F, Lucia A, Pareja-Galeano H, Leyhe T, Turana Y, Lee I, Yoon J, Shin J. Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis. Molecular Neurobiology 2016, 54: 7297-7311. PMID: 27815832, DOI: 10.1007/s12035-016-0192-9.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPeripheral blood BDNF levelsBlood BDNF levelsBrain-derived neurotrophic factor levelsBDNF levelsPeripheral BDNF levelsMeta-analysisMild cognitive impairmentMini-Mental State ExaminationSystematic reviewNeurotrophic factor levelsStatistically significant differenceAD patientsCognitive impairmentComprehensive systematic reviewSubgroup analysisHealthy controlsNeurotrophic factorAlzheimer's diseaseTrophic effectsPatientsBlood biomarkersInclusion criteriaMini-Mental State Examination scoreSignificant difference
2013
Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men
Goda A, Ohgi S, Kinpara K, Shigemori K, Fukuda K, Schneider E. Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men. SpringerPlus 2013, 2: 678. PMID: 24386624, PMCID: PMC3872285, DOI: 10.1186/2193-1801-2-678.Peer-Reviewed Original ResearchModerate-intensity exerciseAcute moderate-intensity exerciseSerum BDNF levelsSerum BDNFHealthy young Japanese menJapanese menBDNF levelsYoung Japanese menSerum brain-derived neurotrophic factor (BDNF) levelsBrain-derived neurotrophic factor levelsNeurotrophic factor levelsMale Japanese subjectsMinutes of exerciseJapanese male subjectsHuman-based studiesAcute exerciseNeurotrophic factorBDNFNeuronal transmissionMale subjectsPurposeThe purposeFactor levelsStationary bicycleJapanese subjectsYoung adults
2008
Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
D’Souza D, Pittman B, Perry E, Simen A. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology 2008, 202: 569. PMID: 18807247, PMCID: PMC2791800, DOI: 10.1007/s00213-008-1333-2.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF levelsBrain-derived neurotrophic factor levelsNeurotrophic factor levelsSerum BDNF levelsΔ9-THCEffects of cannabinoidsΔ9-THC administrationSpatial memory impairmentBasal BDNF levelsResultsΔ9-THCPlacebo administrationPrincipal active componentNeurotrophic factorControl subjectsPsychotomimetic effectsHealthy controlsCannabinoid effectsIntravenous administrationAltered neurodevelopmentPreclinical studiesHigh riskConsequence of exposureChronic exposureMemory impairmentFollicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility
Buyuk E, Seifer DB. Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility. Fertility And Sterility 2008, 90: 1611-1615. PMID: 18222435, DOI: 10.1016/j.fertnstert.2007.08.085.Peer-Reviewed Original ResearchConceptsMale factor infertilityDifferent etiologiesOvarian reserveNerve growth factorBDNF levelsNeurotrophin levelsBrain-derived neurotrophic factor levelsNT-3 concentrationNeurotrophic factor levelsProspective observational studyDiminished ovarian reserveHistory of endometriosisPolycystic ovarian syndromeIVF cyclesOvarian syndromeNGF levelsFollicular fluidNeurotrophin concentrationsObservational studyMAIN OUTCOMENGF concentrationsInfertilityFactor levelsEndometriosisEtiology
2000
Pharmacotherapy of Early-Onset Depression Update and New Directions
Martin A, Kaufman J, Charney D. Pharmacotherapy of Early-Onset Depression Update and New Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 135-157. PMID: 10674194, DOI: 10.1016/s1056-4993(18)30139-1.Peer-Reviewed Original ResearchConceptsEarly-onset depressionDepressive disorderSafety dataLong-term exposureBrain-derived neurotrophic factor levelsLong-term safety dataEarly-onset depressive disordersAvailable antidepressant agentsRigid treatment guidelinesUseful treatment interventionsNeurotrophic factor levelsLong-term followShort-term efficacyShort-term efficacy dataAtrophic brain changesHigh recurrence ratePsychopharmacology Algorithm ProjectRoutine clinical practiceAlternative treatment strategiesYears of ageShort-term trialsPaucity of dataRisk-benefit analysisLong-term useAntidepressant medication
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