2025
Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic function
2024
Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
Mahgoub R, Bayram A, Spencer D, Alkawadri R. Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions. Journal Of Neurology Neurosurgery & Psychiatry 2024, 95: 704-721. PMID: 38242679, DOI: 10.1136/jnnp-2023-332246.Peer-Reviewed Original ResearchPosterior cingulate cortexCingulate gyrusElectrical cortical stimulationCingulate cortexFunctional capacitySystematic reviewInclusion criteriaAnterior cingulate cortexCortical stimulationCingulate functionComplex motor behaviorsCingulate subregionsComplex motorLimbic systemBrain structuresCingulateSpeech responsesSimple motorLiterature reviewMotor behaviorSurgical planningFunctional parcellationAutonomic responsesCorpus callosumImaging modalities
2023
Autonomic nervous system responses to social stimuli among autistic individuals: A systematic review and meta‐analysis
Zadok E, Golan O, Lavidor M, Gordon I. Autonomic nervous system responses to social stimuli among autistic individuals: A systematic review and meta‐analysis. Autism Research 2023, 17: 497-511. PMID: 38073185, DOI: 10.1002/aur.3068.Peer-Reviewed Original ResearchAutonomic nervous system responsesNervous system responsesParasympathetic nervous system activityNervous system activityParasympathetic systemAutonomic regulationPhysiological responsesSystematic reviewAutonomic responsesAutistic individualsAutonomic functioningNT individualsSystem activitySocial stimuliSignificant differencesStudy objectiveOverall differenceHigh heterogeneityPhysiological functionsCurrent studyHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systemsParent Stress and Trauma, Autonomic Responses, and Negative Child Behaviors
Fogelman N, Schwartz J, Chaplin TM, Jastreboff AM, Silverman WK, Sinha R. Parent Stress and Trauma, Autonomic Responses, and Negative Child Behaviors. Child Psychiatry & Human Development 2022, 54: 1779-1788. PMID: 35674991, PMCID: PMC9729425, DOI: 10.1007/s10578-022-01377-w.Peer-Reviewed Original ResearchConceptsNegative child behaviorsTraumatic life eventsParent stressChild behaviorLife eventsParent-child interactionsChild behavioral outcomesGreater heart rate variabilityRecent life eventsChildren's attentionBehavioral outcomesHeart rate variabilityPhysiological copingYear old childrenLife stressAggressive behaviorCumulative stressOlder childrenMore parentsInteraction challengesAutonomic responsesParentsMajor lifeMore childrenChildren
2019
Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers
Wang W, Zhornitsky S, Le TM, Zhang S, Li CR. Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 619-628. PMID: 32061544, PMCID: PMC7286768, DOI: 10.1016/j.bpsc.2019.12.013.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestProblem alcohol useHeart rate variabilityCue exposureAlcohol useAUDIT scoresAutonomic responsesRate variabilityNeutral cue exposureCue exposure paradigmDisorders Identification TestAlcohol cue exposurePrefrontal cortical responsesVentromedial prefrontal cortex activityAlcohol drinkersPrefrontal cortex activityHigher RMSSDCortical responsesParasympathetic responseAlcohol cravingAlcohol misuseVentromedial prefrontal cortexExposure paradigmCortex activityMediation analysis
2018
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic V, Sinha R. Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability. Trends In Molecular Medicine 2018, 24: 173-186. PMID: 29396148, PMCID: PMC6511993, DOI: 10.1016/j.molmed.2017.12.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersTreatment of SUDsDevelopment of SUDHigh relapse rateFunctional brain alterationsCentral stress responseAdrenal axis markersStress response measuresRelapse ratePeripheral biomarkersClinical symptomatologyBrain alterationsUse disordersCandidate biomarkersAutonomic responsesRelapse vulnerabilityPutative biomarkersAddiction riskStress responseBiomarkersTreatmentResponsePathophysiologySymptomatologyPrevention
2016
Preclinical Pharmacology of CW002
Sunaga H, Savarese JJ, McGilvra JD, Heerdt PM, Belmont MR, Van Ornum SG, Murrell MT, Malhotra JK, Savard PM, Jeannotte E, Petty BJ, Allen E, Carnathan GW. Preclinical Pharmacology of CW002. Anesthesiology 2016, 125: 732-743. PMID: 27466033, DOI: 10.1097/aln.0000000000001254.Peer-Reviewed Original ResearchMean arterial pressureNeuromuscular blockadeArterial pressureNondepolarizing neuromuscular blocking agentDose ratioSympathetic autonomic responsesNeuromuscular blocking agentsNeuromuscular blocking propertiesRecovery intervalIncrease of HRSympathetic inhibitionBolus dosesCirculatory effectsPreclinical pharmacologyTwitch inhibitionBlocking agentStudy of safetyInstitutional Animal CareAnesthetized monkeysHeart rateSpontaneous recoveryED95CW002Autonomic responsesRapid reversal
2015
Endocrine‐Autonomic Linkages
Sladek C, Michelini L, Stachenfeld N, Stern J, Urban J. Endocrine‐Autonomic Linkages. Comprehensive Physiology 2015, 5: 1281-1323. DOI: 10.1002/j.2040-4603.2015.tb00634.x.Peer-Reviewed Original ResearchPreganglionic autonomic neuronsHypothalamic paraventricular nucleusAutonomic nervous systemAutonomic neuronsParaventricular nucleusNeuroendocrine neuronsNeuroendocrine actionsPeripheral hormonesParasympathetic outflowGonadal steroidsBlood pressureMaintenance of homeostasisNeuronal populationsElectrolyte balanceNervous systemNeuroendocrine systemAutonomic mechanismsEnergy homeostasisAutonomic responsesAutonomous systemsNeuronsBody temperatureHomeostasisPhysiological mechanismsEndocrine‐Autonomic Linkages
Sladek CD, Michelini LC, Stachenfeld NS, Stern JE, Urban JH. Endocrine‐Autonomic Linkages. 2015, 5: 1281-1323. PMID: 26140719, DOI: 10.1002/cphy.c140028.Peer-Reviewed Original ResearchConceptsHypothalamic paraventricular nucleusAutonomic nervous systemParasympathetic outflowPeripheral hormonesAutonomic neuronsBlood pressureNeuroendocrine actionsGonadal steroidsParaventricular nucleusMaintenance of homeostasisElectrolyte balanceNeuroendocrine neuronsNervous systemNeuronal populationsAutonomic responsesNeuroendocrine systemAutonomic mechanismsEnergy homeostasisNeuroendocrineBody temperatureNeuronsAutonomic systemPhysiological mechanismsHomeostasisPhysiological parameters
2004
Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function
Vashist A, Arrighi J, Lampert R, Burg M, Soufer R. Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function. Journal Of Nuclear Cardiology 2004, 11: s21. DOI: 10.1016/j.nuclcard.2004.06.068.Peer-Reviewed Original ResearchChronic coronary artery diseaseRegional LV dysfunctionMyocardial ischemiaParasympathetic withdrawalLV dysfunctionChronic chronic coronary artery diseaseMental stress ischemiaRate-pressure productCoronary artery diseaseGreater parasympathetic withdrawalHigh-frequency powerStress ischemiaArtery diseaseNon-invasive imagingMPI defectsSympathovagal balanceIndividual patientsSPECT-MPIIschemiaMyocardial perfusionNoninvasive evaluationPatientsMental arithmetic taskAutonomic responsesSPECT defects
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