2024
Altered Heart Rate Variability During Mobile Game Playing and Watching Self-Mobile Gaming in Individuals with Problematic Mobile Game Use: Implications for Cardiac Health
Chin S, Chang Y, Huang C, Chou T, Huang C, Lin H, Potenza M. Altered Heart Rate Variability During Mobile Game Playing and Watching Self-Mobile Gaming in Individuals with Problematic Mobile Game Use: Implications for Cardiac Health. Psychology Research And Behavior Management 2024, 17: 2545-2555. PMID: 38973973, PMCID: PMC11226189, DOI: 10.2147/prbm.s469240.Peer-Reviewed Original ResearchMobile gamesMobile game useMobile game playMobile-gamingHeart rate variabilityGame playInternet accessElevated LF/HF ratioAltered heart rate variabilityGameGame useGame activitiesRate variabilityGaming behaviorCraving scoresGaming QuestionnaireAutonomic arousalLF/HF ratioGameplayVideo excerptsLow-frequency to high-frequencySmartphoneInternetVideoPotential intervention strategiesBrain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation
Seo D, Martins J, Sinha R. Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology Of Stress 2024, 31: 100645. PMID: 38933283, PMCID: PMC11201348, DOI: 10.1016/j.ynstr.2024.100645.Peer-Reviewed Original ResearchAutonomic nervous system disruptionAlcohol use disorderFunctional magnetic resonance imagingHigh-risk drinkingSocial drinkersFunctional connectivityLow-risk drinkingAlcohol motivationAutonomic arousalDevelopment of alcohol use disordersNeural correlates of stressNon-dependent social drinkersWhole-brain correlation analysesResponse to stress exposureAlcohol taste testFrontal-striatal regionsStress-induced cravingVentromedial prefrontal cortexBehaviors associated with stressAnterior cingulate cortexDecreased functional connectivityExposure to stressAutonomic nervous systemAlcohol intakeHazardous alcohol use
2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingPregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
2018
The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque
Weinberg-Wolf H, Fagan NA, Anderson GM, Tringides M, Dal Monte O, Chang SWC. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacology 2018, 43: 1589-1598. PMID: 29463909, PMCID: PMC5983545, DOI: 10.1038/s41386-017-0003-7.Peer-Reviewed Original ResearchConceptsSerotonergic interventionsSalient facial featuresCentral serotonergic functioningCisternal cerebrospinal fluidBaseline attentionCognitive operationsSerotonin's roleIndividual differencesBi-directional effectsAutonomic arousalSaline sessionsImmediate serotonin precursorEngaged individualsBehavioral impairmentsFacial featuresSerotonergic functioningStimulus animalsRole of serotoninPupil sizeAnxietyPsychiatric disordersSerotonin neurochemistrySerotoninergic functionSerotonin effectsCSF concentrations
2014
Autonomic Arousal and Learning in Web‐Based Simulation: A Feasibility Study
Gorrindo T, Chevalier L, Goldfarb E, Hoeppner BB, Birnbaum RJ. Autonomic Arousal and Learning in Web‐Based Simulation: A Feasibility Study. Journal Of Continuing Education In The Health Professions 2014, 34: s17-s22. PMID: 24935879, DOI: 10.1002/chp.21234.Peer-Reviewed Original ResearchConceptsAutonomic arousal
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway
2007
Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar
Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA‐Ar. Alcohol Clinical And Experimental Research 2007, 31: 612-618. PMID: 17374040, DOI: 10.1111/j.1530-0277.2007.00345.x.Peer-Reviewed Original ResearchConceptsAlcohol withdrawal syndromeCIWA-ArClinical Institute Withdrawal Assessment-AlcoholSymptom ChecklistCIWA-Ar scoresFirst study dayInpatient treatment unitAlcohol-dependent male inpatientsObserver-rated scalesAlcohol withdrawalWithdrawal syndromeTension/anxietyMale inpatientsIndependent factorsStudy daysClinical relevanceSelf-rating scaleAlcohol cravingObserver-rated measuresDiscriminative valueSelf-rated measuresInitial weeksAutonomic arousalFace validityResearch settings
2006
Anxiety sensitivity and auditory perception of heartbeat
Pollock R, Carter A, Amir N, Marks L. Anxiety sensitivity and auditory perception of heartbeat. Behaviour Research And Therapy 2006, 44: 1739-1756. PMID: 16513082, DOI: 10.1016/j.brat.2005.12.013.Peer-Reviewed Original ResearchConceptsAnxiety sensitivityElevated false alarm rateFear-relevant cuesAuditory perceptionThreat signalsAutonomic arousalDetection paradigmAS individualsPanic disorderPanic patientsPanic attacksLow abilityPerceptionTaskIndividualsCardiac stimuliArousalCuesGreater propensityFalse alarm rateBackground noiseFearStimuliAbilityNormal heartbeats
2004
Attentional bias for valenced stimuli as a function of personality in the dot-probe task
Amin Z, Constable R, Canli T. Attentional bias for valenced stimuli as a function of personality in the dot-probe task. Journal Of Research In Personality 2004, 38: 15-23. DOI: 10.1016/j.jrp.2003.09.011.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAttentional biasAttentional tasksDot-probe taskDimensions of affectFunction of personalityDimensions of personalityValenced stimuliAttentional probeEmotional stimuliNegative affectFusiform gyrusVisual searchGreater activationAutonomic arousalBrain regionsVisual fieldTaskAffectPersonalityIncreased effortStimuliMagnetic resonance imagingBiasNeuroticism
1995
Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply
Southwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.Peer-Reviewed Original Research
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