2022
Magnetic Resonance Imaging of Acute Abdominal Pain in the Pregnant Patient
Stanley AD, Tembelis M, Patlas MN, Moshiri M, Revzin MV, Katz DS. Magnetic Resonance Imaging of Acute Abdominal Pain in the Pregnant Patient. Magnetic Resonance Imaging Clinics Of North America 2022, 30: 515-532. PMID: 35995477, DOI: 10.1016/j.mric.2022.04.010.Peer-Reviewed Original ResearchConceptsAcute abdominal painAbdominal painPregnant patientsAccurate diagnostic imaging modalityComputed tomography scanMagnetic resonance imagingDiagnostic imaging modalitiesCommon gastrointestinalGynecologic causesTomography scanUltrasound examinationTraumatic injuryNoncontrast MRPathologic processesPainResonance imagingPatientsRadiation exposureImaging modalitiesPregnancyMost settingsVariety of reasonsGastrointestinalInjury
2020
Identification of NPTX2 as a prognostic biomarker of Alzheimer’s disease through a longitudinal CSF proteomics study in ADNI subjects
Libiger O, Shaw L, Watson M, Nairn A, Umaña K, Canet‐Avilés R, Jack C, Breton Y, Cortes L, Chelsky D, Spellman D, Baker S, Raghavan N, Potter W. Identification of NPTX2 as a prognostic biomarker of Alzheimer’s disease through a longitudinal CSF proteomics study in ADNI subjects. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047605.Peer-Reviewed Original ResearchP-Tau 181Alzheimer's diseasePrognostic biomarkerRate of declineADNI subjectsLongitudinal changesTau-tangle pathologyBaseline clinical diagnosisAssociation of changesPre-specified analysis planMild cognitive impairmentTangle pathologyClinical progressionMixed-effects linear modelNegative subjectsClinical prognosisDisease continuumAdditional biomarkersAmyloid plaquesDrug development effortsNormal subjectsSubset of individualsRetrospective investigationBiomarker profilesPathologic processes
2019
Infected Ischemic Foot: Investigation
Miller S, Sumpio B, Sumpio B. Infected Ischemic Foot: Investigation. 2019, 481-495. DOI: 10.1007/978-3-319-17918-6_38.Peer-Reviewed Original ResearchIschemic footAssessment of ischemiaFocused physical examDiabetic patientsLimb salvageWound infectionPhysical examAncillary testingPatient historyPathologic processesDisease resultsSeparate diagnosisDiagnostic imagingDistinct diagnosisInfectionPrimary locationHealing capacityDistal partDiagnosisFootLaboratory testingCommon occurrenceUlcerationIschemiaPatientsVertebral Artery Ultrasound
Gunabushanam G, Kummant L, Scoutt LM. Vertebral Artery Ultrasound. Radiologic Clinics Of North America 2019, 57: 519-533. PMID: 30928075, DOI: 10.1016/j.rcl.2019.01.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVertebral artery stenosisVertebral arteryArtery stenosisVertebral artery waveformsExtracranial vertebral arterySpectral Doppler waveformsArteriovenous fistulaStent placementDifferential diagnosisDoppler waveformsUltrasound appearanceUltrasound criteriaPathologic processesNormal anatomyArteryStenosisUltrasound imagingPseudoaneurysmFistula
2017
Induction of a BRCAness state by oncometabolites and exploitation by PARP inhibitors.
Bindra R, Sulkowski P, Corso C, Glazer P, Shuch B. Induction of a BRCAness state by oncometabolites and exploitation by PARP inhibitors. Journal Of Clinical Oncology 2017, 35: 11586-11586. DOI: 10.1200/jco.2017.35.15_suppl.11586.Peer-Reviewed Original ResearchAcute myeloid leukemiaMulti-center phase II trialIDH1/2 mutationsPARP inhibitorsMutant IDH1/2 inhibitorsPhase II trialEfficacy of olaparibPoly (ADP-ribose) polymerase (PARP) inhibitorsRelated gene mutationsHomologous recombination defectsII trialIDH1/2 inhibitorsMyeloid leukemiaIsocitrate dehydrogenase 1Therapeutic strategiesPathologic processesSmall molecule inhibitorsIDH1/2-mutant tumorsSmall molecule inhibitionTumor progressionDNA repair inhibitorsPolymerase inhibitorsModern oncologyTumor cellsKey mediatorSelective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI
Ishchenko Y, Shakirzyanova A, Giniatullina R, Skorinkin A, Bart G, Turhanen P, Määttä J, Mönkkönen J, Giniatullin R. Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI. Journal Of Pharmacology And Experimental Therapeutics 2017, 361: 472-481. PMID: 28404687, DOI: 10.1124/jpet.116.238840.Peer-Reviewed Original ResearchConceptsNitrogen-Containing BisphosphonatesP2X3 receptorsP2X7 receptorBone cancerInhibitory actionBone resorptive disordersNodose ganglion neuronsRat sensory neuronsPrimary bone cancerRat P2X3 receptorsPatch-clamp techniqueWeak agonist activityCalcium-dependent inhibitionBone metastasesTrigeminal neuronsPurinergic mechanismsUnbearable symptomsGanglion neuronsReceptor subtypesSensory neuronsP2X receptorsPathologic processesAgonist activityHuman P2X3Human embryonic kidney cellsClinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care
Wang Y, Spincemaille P, Liu Z, Dimov A, Deh K, Li J, Zhang Y, Yao Y, Gillen KM, Wilman AH, Gupta A, Tsiouris AJ, Kovanlikaya I, Chiang G, Weinsaft JW, Tanenbaum L, Chen W, Zhu W, Chang S, Lou M, Kopell BH, Kaplitt MG, Devos D, Hirai T, Huang X, Korogi Y, Shtilbans A, Jahng G, Pelletier D, Gauthier SA, Pitt D, Bush AI, Brittenham GM, Prince MR. Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care. Journal Of Magnetic Resonance Imaging 2017, 46: 951-971. PMID: 28295954, PMCID: PMC5592126, DOI: 10.1002/jmri.25693.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingQuantitative susceptibility mappingPatient careGradient-echo magnetic resonance imagingEcho magnetic resonance imagingAbnormal oxygen consumptionContrast agent injectionNormal cellular biochemistryMRI diagnosisPathologic processesMRI protocolResonance imagingAgent injectionBone mineralizationSpatial biodistributionGradient echo sequencePathologic calcificationJ. MagnTechnical efficacyDiseaseClinical applicationOxygen consumptionClinical translationMRI practiceImaging practicesEx Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles
Vallabhajosyula P, Korutla L, Habertheuer A, Reddy S, Schaufler C, Lasky J, Diamond J, Cantu E. Ex Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles. The Annals Of Thoracic Surgery 2017, 103: 1758-1766. PMID: 28242077, PMCID: PMC11980036, DOI: 10.1016/j.athoracsur.2016.11.074.Peer-Reviewed Original ResearchConceptsEVLP systemWestern blot analysisTransplant groupExtracellular microvesiclesVivo lung perfusion modelTime pointsMarginal donor lungsLung perfusion modelFollowing time pointsTranscription-polymerase chain reactionBlot analysisEV size distributionMarginal lungsNontransplant groupDonor lungsLung recoveryLung perfusionSteen solutionPolymerase chain reactionPulmonary parenchymaEV protein cargoPathologic processesPerfusion modelTissue-specific markersPerfusate exchange2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine 2017, 9 PMID: 28148839, PMCID: PMC5435119, DOI: 10.1126/scitranslmed.aal2463.Peer-Reviewed Original ResearchConceptsIsocitrate dehydrogenase 1PARP inhibitor sensitivityPossible therapeutic strategiesHomologous recombination defectsTherapeutic strategiesTumor xenograftsInhibitor sensitivityPathologic processesSmall molecule inhibitorsIDH1/2 mutationsTumor progressionIDH2 mutationsMutant IDHPolymerase inhibitorsGlioma cellsTumor cellsHR deficiencyPARP inhibitionIDH mutationsInhibitory effectDehydrogenase 1Neomorphic activityMutant IDH1 enzymeDependent dioxygenasesMutant cells
2015
Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB)
Liang S, Yokell D, Jackson R, Rice P, Livni E, Alagille D, Tamagnan G, Collier T, Vasdev N. Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB). 2015, 41-51. DOI: 10.1002/9781118834114.ch5.Peer-Reviewed Original ResearchMetabotropic glutamate receptor subtype 5Regional brain concentrationsHealthy human subjectsBrain concentrationsBrain penetranceMGluR5 antagonistSubtype 5Parkinson's diseasePathologic processesAlzheimer's diseaseNeuropsychiatric disordersNeurodegenerative diseasesDiseaseHigh potencyHuman subjectsEvidence pointsFragile X syndromeControl testsRadiochemical purityCritical roleX syndromeMGluR5SyndromeAntagonistAbnormalitiesThe Wonderful World of the Windpipe: A Review of Central Airway Anatomy and Pathology
Lawrence DA, Branson B, Oliva I, Rubinowitz A. The Wonderful World of the Windpipe: A Review of Central Airway Anatomy and Pathology. Canadian Association Of Radiologists Journal 2015, 66: 30-43. PMID: 25623009, DOI: 10.1016/j.carj.2014.08.003.Peer-Reviewed Original Research
2014
Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy
Vudattu NK, Waldron-Lynch F, Truman LA, Deng S, Preston-Hurlburt P, Torres R, Raycroft MT, Mamula MJ, Herold KC. Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy. The Journal Of Immunology 2014, 193: 587-596. PMID: 24943216, PMCID: PMC4123131, DOI: 10.4049/jimmunol.1302455.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAutoimmune DiseasesCytokinesDisease Models, AnimalFlow CytometryHumansInterleukin Receptor Common gamma SubunitIpilimumabLiverLymphocyte ActivationMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDPhosphorylationSTAT5 Transcription FactorStem Cell TransplantationSurvival AnalysisT-LymphocytesT-Lymphocytes, RegulatoryTransplantation, HeterologousWeight LossConceptsAnti-nuclear AbsAutoimmune diseasesRegulatory cellsHumanized miceT cellsImmune responseWeight lossMesenteric lymph nodesHuman autoimmune diseasesInduction of autoimmunityT-cell immunotherapyRelease of IFNHuman immune responseImmune-deficient miceIpilimumab treatmentInflammatory sequelaeLymph nodesCell immunotherapyIP-10Macrophage infiltrationCytokine productionSpleen cellsPathologic processesHepatitisMice
2013
Biologic treatments for shoulder pain
Varthi A, Piposar J, Chan W, Blaine T. Biologic treatments for shoulder pain. Current Orthopaedic Practice 2013, 24: 360-364. DOI: 10.1097/bco.0b013e31829a8d5b.Peer-Reviewed Original ResearchShoulder painPlatelet-rich plasmaBiologic treatmentRich plasmaGrowth factorCommon musculoskeletal complaintSevere shoulder painPromising new therapyUse of cytokinesRotator cuff diseaseStem cellsOral medicationsSevere painMusculoskeletal complaintsTreatment modalitiesCuff diseaseInjectable medicationsPowerful medicationsNew therapiesPainPathologic processesShoulder pathologyMedicationsPatientsPhysicians
2012
A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort
Meda SA, Narayanan B, Liu J, Perrone-Bizzozero NI, Stevens MC, Calhoun VD, Glahn DC, Shen L, Risacher SL, Saykin AJ, Pearlson GD. A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort. NeuroImage 2012, 60: 1608-1621. PMID: 22245343, PMCID: PMC3312985, DOI: 10.1016/j.neuroimage.2011.12.076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainCanadaCohort StudiesData Interpretation, StatisticalFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleMultivariate AnalysisPolymorphism, Single NucleotidePrevalencePrincipal Component AnalysisReproducibility of ResultsSensitivity and SpecificityUnited StatesConceptsLate-onset Alzheimer's diseaseMagnetic resonance imagingAlzheimer's diseaseOnset Alzheimer's diseaseAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortElderly healthy controlsAmnestic mild cognitive impairmentDifferent brain regionsMild cognitive impairmentStructural MRI scansHealthy controlsCardiovascular diseaseInitiative cohortMRI scansPathologic processesCognitive impairmentResonance imagingBrain regionsSingle nucleotide polymorphism (SNP) variantsCaucasian adultsSubject cohortDiseasePhysiologic pathwaysCohortPolymorphism variants
2011
Chapter 8 B-Lymphocyte Biology in SLE
Mamula M. Chapter 8 B-Lymphocyte Biology in SLE. 2011, 143-161. DOI: 10.1016/b978-0-12-374994-9.10008-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusHuman systemic lupus erythematosusAntigen-presenting cellsB cellsDiagnostic hallmarkAutoreactive B cell responsesB-cell-specific therapiesClinical systemic lupus erythematosusB lymphocyte subsetsIgG class autoantibodiesB cell responsesT lymphocyte interactionsMultiple cellular abnormalitiesDendritic cellsLupus erythematosusAutoantibody responseLupus autoantigensClass autoantibodiesT cellsMurine modelB lymphocyte biologyGenetic predispositionReceptor inductionPathologic processesTissue pathology
2010
microRNAs, Plasma Lipids, and Cardiovascular Disease
Dávalos A, Fernández-Hernando C. microRNAs, Plasma Lipids, and Cardiovascular Disease. Current Cardiovascular Risk Reports 2010, 5: 10-17. DOI: 10.1007/s12170-010-0145-1.Peer-Reviewed Original ResearchCardiovascular diseaseShort non-coding RNAsPost-transcriptional repressionHigh-density lipoprotein biogenesisMiR-33Non-coding RNAsTotal cholesterol levelsCassette transporter A1Expression of ATPMiR-122 expressionAberrant regulationGene expressionLipoprotein biogenesisDyslipidemic patientsLipid homeostasisMetabolic syndromePlasma lipidsCholesterol levelsLeading causeLipoprotein metabolismABCG1 transportersCholesterol effluxCholesterol metabolismPathologic processesMultifactorial disorderCauses of Ischemic Stroke
Silva G, Koroshetz W, González R, Schwamm L. Causes of Ischemic Stroke. 2010, 25-42. DOI: 10.1007/978-3-642-12751-9_2.Peer-Reviewed Original ResearchIschemic strokeCryptogenic strokeSmall infarctionClinical workupMajor disabilityClinical signsDefinite causeUnknown causeHeterogeneous diseaseLacunar mechanismPathologic processesLarge seriesStrokeOrgan systemsGroups of strokesReporting systemCauseBrainInfarctionIschemiaPatientsMajorityWorkupDisease
2005
Abnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatients
1997
The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity
Alpern R, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity. American Journal Of Kidney Diseases 1997, 29: 291-302. PMID: 9016905, DOI: 10.1016/s0272-6386(97)90045-7.Peer-Reviewed Original ResearchConceptsChronic metabolic acidosisMetabolic acidosisHomeostatic responseSerum HCO3Acid loadBody's homeostatic responseHomeostatic mechanismsMuscle protein breakdownNormal homeostatic mechanismsSignificant morbidityClinical spectrumMeat ingestionBone demineralizationRenal growthClinical conditionsPathologic processesPathologic consequencesAcidosisProtein breakdownBloodResponseMorbidityPatientsNephrolithiasisIngestion
1981
The Pathophysiology of disorders of oxygen transport in the infant
Talner N, Lister G. The Pathophysiology of disorders of oxygen transport in the infant. Current Problems In Pediatric And Adolescent Health Care 1981, 11: 7-50. PMID: 7226876, DOI: 10.1016/0045-9380(81)90037-2.Peer-Reviewed Original ResearchConceptsPathophysiology of disordersLower airwaysSurgical treatmentClinical presentationPathophysiologic mechanismsPulmonary circulationHematologic systemLung parenchymaOxygen deliveryPathologic processesControl of respirationOrgan systemsOxygen uptakeLungInfantsTissueDisordersSupply of oxygenHeartAdaptive responseCirculationAirwayPathophysiologyLesionsOxygen transport
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