2023
Anti-tumor Efficacy of CD19 CAR-T in a Raji B Cell Xenografted Mouse Model
Xiao Q, Su X. Anti-tumor Efficacy of CD19 CAR-T in a Raji B Cell Xenografted Mouse Model. Bio-protocol 2023, 13: e4655. PMID: 37113332, PMCID: PMC10127058, DOI: 10.21769/bioprotoc.4655.Peer-Reviewed Original ResearchCAR T cellsCD19 CAR T cellsRefractory B-cell malignanciesCell-induced tumorsChimeric antigen receptorImmune-deficient miceAnti-tumor efficacyB-cell malignanciesMouse xenograft modelTumor-killing abilityXenografted mouse modelCAR-TsT therapyHealthy donorsCD19-CARMouse modelXenograft modelTumor growthPreclinical researchTumor cellsCancer treatmentAntigen receptorMiceCellsMalignancy
2016
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. Journal Of Clinical Investigation 2016, 126: 3905-3916. PMID: 27617863, PMCID: PMC5096804, DOI: 10.1172/jci85329.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsMemory T cellsT cellsTRM cellsCellular therapyAdoptive cellular therapyImmune-deficient micePotential cellular therapySP T cellsSide population cellsHuman T cellsPutative subsetsAdoptive transferDistinct gene expression profilesCell mobilizationImmune surveillanceQuiescent subsetPopulation cellsMiceTherapyQuiescent phenotypeDistinct subsetsMember 1Nuclear receptorsSignature genes
2015
Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice
Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu M, Borsotti C, Zhang L, Branagan A, Eynon E, Manz M, Flavell R, Dhodapkar M. Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice. Blood 2015, 126: 120. DOI: 10.1182/blood.v126.23.120.120.Peer-Reviewed Original ResearchBone marrow mononuclear cellsMultiple myelomaMarrow mononuclear cellsPlasma cellsPlasma cell tumorsInterleukin-6Tumor cellsAsymptomatic MMHumanized miceMononuclear cellsCell tumorsFlow cytometryPathogenesis of MMAsymptomatic multiple myelomaExtra-medullary sitesSetting of patientsHuman MM cellsInnate immune cellsPlasma cell disordersPlasma cell leukemiaPlasma cell cloneImmune-deficient miceHuman plasma cell tumorsInnate immune cell developmentSingle-cell mass cytometry
2014
Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy
Vudattu NK, Waldron-Lynch F, Truman LA, Deng S, Preston-Hurlburt P, Torres R, Raycroft MT, Mamula MJ, Herold KC. Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy. The Journal Of Immunology 2014, 193: 587-596. PMID: 24943216, PMCID: PMC4123131, DOI: 10.4049/jimmunol.1302455.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAutoimmune DiseasesCytokinesDisease Models, AnimalFlow CytometryHumansInterleukin Receptor Common gamma SubunitIpilimumabLiverLymphocyte ActivationMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDPhosphorylationSTAT5 Transcription FactorStem Cell TransplantationSurvival AnalysisT-LymphocytesT-Lymphocytes, RegulatoryTransplantation, HeterologousWeight LossConceptsAnti-nuclear AbsAutoimmune diseasesRegulatory cellsHumanized miceT cellsImmune responseWeight lossMesenteric lymph nodesHuman autoimmune diseasesInduction of autoimmunityT-cell immunotherapyRelease of IFNHuman immune responseImmune-deficient miceIpilimumab treatmentInflammatory sequelaeLymph nodesCell immunotherapyIP-10Macrophage infiltrationCytokine productionSpleen cellsPathologic processesHepatitisMice
2010
The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina. Neuron 2010, 65: 503-515. PMID: 20188655, PMCID: PMC3037728, DOI: 10.1016/j.neuron.2010.01.035.Peer-Reviewed Original ResearchConceptsEye-specific segregationCentral nervous systemRetinal ganglion cellsDendritic motilitySynaptic activityActivity-dependent synapse formationPossible retinal originRGC axon projectionImmune proteinsImmune-deficient miceDendritic densityGanglion cellsClass I major histocompatibility complex genesRetinal originNervous systemSynapse formationAxon projectionsMHCI receptorNeural circuitsSynaptic wiringSelective defectMajor histocompatibility complex (MHC) genesMiceRetinaNormal development
2004
Stabilized β-catenin promotes hepatocyte proliferation and inhibits TNFα-induced apoptosis
Shang X, Zhu H, Lin K, Tu Z, Chen J, Nelson D, Liu C. Stabilized β-catenin promotes hepatocyte proliferation and inhibits TNFα-induced apoptosis. Laboratory Investigation 2004, 84: 332-341. PMID: 14767485, DOI: 10.1038/labinvest.3700043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisbeta CateninCarcinoma, HepatocellularCell DivisionCell LineCell Line, TumorCell Transformation, NeoplasticCyclin D1Cytoskeletal ProteinsDrug StabilityGene Expression RegulationGenes, mycHepatocytesHumansLiver NeoplasmsMiceMice, SCIDMutationTrans-ActivatorsTransfectionTumor Necrosis Factor-alphaConceptsHuman hepatocellular carcinomaHepatocyte proliferationCell linesCommon malignant tumorCell proliferationImmune-deficient miceCell survival abilityLiver cell growthMurine hepatocyte cell lineCell growthHepatocyte cell lineAnchorage-independent cell growthMalignant tumorsHepatocellular carcinomaLiver cancerCyclin D1Inhibits TNFαOncogenic transformationCell apoptosisBeta-catenin mutationsAct DΒ-cateninPotential roleC-MycTumors
1998
Abnormal Transglutaminase 1 Expression Pattern in a Subset of Patients with Erythrodermic Autosomal Recessive Ichthyosis
Choate K, Khavari P, Williams M. Abnormal Transglutaminase 1 Expression Pattern in a Subset of Patients with Erythrodermic Autosomal Recessive Ichthyosis. Journal Of Investigative Dermatology 1998, 110: 8-12. PMID: 9424079, DOI: 10.1046/j.1523-1747.1998.00070.x.Peer-Reviewed Original ResearchConceptsCongenital ichthyosiform erythrodermaCIE patientsAutosomal recessive ichthyosisRecessive ichthyosisInternal organ involvementSubset of patientsLamellar ichthyosisImmune-deficient miceNonbullous congenital ichthyosiform erythrodermaAbnormal intracellular accumulationClassic lamellar ichthyosisGroup of diseasesErythrodermic psoriasisOrgan involvementAtopic dermatitisClinical featuresDeficient miceMinimal erythemaPatientsSkin disordersNetherton syndromeSpecific abnormalitiesAbnormal cornificationSkin rednessIchthyosiform erythroderma
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