Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI
Ishchenko Y, Shakirzyanova A, Giniatullina R, Skorinkin A, Bart G, Turhanen P, Määttä J, Mönkkönen J, Giniatullin R. Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI. Journal Of Pharmacology And Experimental Therapeutics 2017, 361: 472-481. PMID: 28404687, DOI: 10.1124/jpet.116.238840.Peer-Reviewed Original ResearchConceptsNitrogen-Containing BisphosphonatesP2X3 receptorsP2X7 receptorBone cancerInhibitory actionBone resorptive disordersNodose ganglion neuronsRat sensory neuronsPrimary bone cancerRat P2X3 receptorsPatch-clamp techniqueWeak agonist activityCalcium-dependent inhibitionBone metastasesTrigeminal neuronsPurinergic mechanismsUnbearable symptomsGanglion neuronsReceptor subtypesSensory neuronsP2X receptorsPathologic processesAgonist activityHuman P2X3Human embryonic kidney cells
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