2025
ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection
Liang C, Zhai T, Chen J, Fang S, Zhu Y, Liu L, Yu N, Zhao H. ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421995122. PMID: 40540593, PMCID: PMC12207453, DOI: 10.1073/pnas.2421995122.Peer-Reviewed Original ResearchConceptsCochlear efferent systemHearing sensitivityATP-gated P2X7 receptorP2X7 receptorOuter hair cellsAuditory nerveInnervate outer hair cellsEfferent systemAuditory brainstem responseSpiral ganglion (SGActive cochlear amplificationActive cochlear mechanicsEfferent nervesP2X7 KO miceIncreased susceptibility to noiseSusceptibility to noiseNeuronal functionAcoustic startle responseHair cellsBrainstem responseHearing lossEfferent suppressionHearing disordersOHC electromotilityNoise exposure
2022
Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
Raval NR, Wetherill RR, Wiers CE, Dubroff JG, Hillmer AT. Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies. Seminars In Nuclear Medicine 2022, 53: 213-229. PMID: 36270830, PMCID: PMC11261531, DOI: 10.1053/j.semnuclmed.2022.08.008.Peer-Reviewed Original Research In PressConceptsNeuroimmune targetsImmune systemNeuropsychiatric conditionsSphingosine-1-phosphate receptor 1Brain immune systemPurinergic P2X7 receptorVivo positron emission tomography (PET) imagingNitric oxide synthasePurinergic P2Y12 receptorPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyTranslocator protein 18Neuroimmune responsePET findingsNeuroimmune systemP2X7 receptorCyclooxygenase-2Oxide synthaseP2Y12 receptorPET resultsMonoamine oxidase BCyclooxygenase-1Colony-stimulating factor-1Receptor 1
2019
P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury
Luz H, Reichel M, Unwin R, Mutig K, Najenson A, Tonner L, Eckardt K, Tam F, Knauf F. P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury. Scientific Reports 2019, 9: 20086. PMID: 31882798, PMCID: PMC6934555, DOI: 10.1038/s41598-019-56560-2.Peer-Reviewed Original ResearchConceptsIL-1ß releaseDendritic cellsKidney failureP2X7 receptorBone marrowNLRP3/CASPP2X7 receptor signalingProgressive kidney diseaseSuitable therapeutic targetProgressive kidney failureMonosodium urate crystalsHuman peripheral bloodKidney injuryRenal inflammationRenal injuryTubular damageWT miceIL-1ssKidney diseasePeripheral bloodCytokine releasePlasma creatinineMurine bone marrowInterleukin-1betaInflammasome activation
2017
Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States
Ishchenko Y, Novosolova N, Khafizov K, Bart G, Timonina A, Fayuk D, Skorinkin A, Giniatullin R. Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States. Biochemistry 2017, 56: 3394-3402. PMID: 28616989, DOI: 10.1021/acs.biochem.7b00258.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBinding SitesBiological Transport, ActiveComputer SimulationFluorescent DyesHEK293 CellsHumansKineticsLigandsModels, MolecularPatch-Clamp TechniquesPoint MutationProtein Interaction Domains and MotifsProtein StabilityPurinergic P2X Receptor AgonistsPurinergic P2X Receptor AntagonistsRatsReceptors, Purinergic P2X7Recombinant ProteinsSerineConceptsRat P2X7 receptorP2X7 receptorSerine 288Novel phenotypesCorresponding residuesPosition 288MM ATPHuman P2X7 receptorMolecular modeling dataF288Agonist bindingATPReceptor statesP2X receptorsReceptor desensitizationPhenotypeATP concentrationFast deactivation ratesResiduesReceptorsKey roleS applicationMutantsSerineWT valuesSelective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI
Ishchenko Y, Shakirzyanova A, Giniatullina R, Skorinkin A, Bart G, Turhanen P, Määttä J, Mönkkönen J, Giniatullin R. Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI. Journal Of Pharmacology And Experimental Therapeutics 2017, 361: 472-481. PMID: 28404687, DOI: 10.1124/jpet.116.238840.Peer-Reviewed Original ResearchConceptsNitrogen-Containing BisphosphonatesP2X3 receptorsP2X7 receptorBone cancerInhibitory actionBone resorptive disordersNodose ganglion neuronsRat sensory neuronsPrimary bone cancerRat P2X3 receptorsPatch-clamp techniqueWeak agonist activityCalcium-dependent inhibitionBone metastasesTrigeminal neuronsPurinergic mechanismsUnbearable symptomsGanglion neuronsReceptor subtypesSensory neuronsP2X receptorsPathologic processesAgonist activityHuman P2X3Human embryonic kidney cells
2016
Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions
Yegutkin G, Guerrero-Toro C, Kilinc E, Koroleva K, Ishchenko Y, Abushik P, Giniatullina R, Fayuk D, Giniatullin R. Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions. Purinergic Signalling 2016, 12: 561-574. PMID: 27369815, PMCID: PMC5023636, DOI: 10.1007/s11302-016-9521-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateAdenosine MonophosphateAdenosine TriphosphateAnimalsCalcitonin Gene-Related PeptideCell SeparationDisease Models, AnimalHomeostasisImmunohistochemistryMaleMeningesMigraine DisordersNucleotidesPatch-Clamp TechniquesRatsRats, WistarReceptors, PurinergicTrigeminal GanglionConceptsCalcitonin gene-related peptideMigraine painTrigeminal cellsRat meningesAdenosine concentrationExtracellular ATPMedial meningeal arteryPro-nociceptive effectsGene-related peptideTrigeminal nerve fibersLarge intracellular Ca2Meningeal nervesTrigeminal painPurinergic mechanismsTrigeminal nervePurinergic hypothesisP2X7 receptorGlial cellsMigraine headacheNerve fibersMeningeal arteryIntracellular Ca2MeningesPainExtracellular AMP
2014
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. The FASEB Journal 2014, 29: 61-69. PMID: 25318477, PMCID: PMC4285537, DOI: 10.1096/fj.14-261867.Peer-Reviewed Original ResearchConceptsRenin releaseRenin-angiotensin systemMast cellsVentricular fibrillationRas activationHMC-1Murine bone marrow-derived mast cellsLocal renin-angiotensin systemBone marrow-derived mast cellsCardiac mast cellsNovel cardioprotective roleMarrow-derived mast cellsPurinergic P2X7 receptorIschemia/reperfusionHeart mast cellsCD39 inhibitionCD39 overexpressionP2X7R blockadeNorepinephrine overflowCardioprotective effectsCardioprotective roleP2X7 receptorCD39Pharmacological inhibitionATP release
2009
Ependymal cells along the lateral ventricle express functional P2X7 receptors
Genzen JR, Platel JC, Rubio ME, Bordey A. Ependymal cells along the lateral ventricle express functional P2X7 receptors. Purinergic Signalling 2009, 5: 299-307. PMID: 19274488, PMCID: PMC2717311, DOI: 10.1007/s11302-009-9143-5.Peer-Reviewed Original ResearchP2X7 receptorEpendymal cellsSubventricular zoneWhole-cell patch-clamp recordingsCentral nervous system injuryFunctional P2X7 receptorsFunctional purinergic receptorsNervous system injuryPatch-clamp recordingsMouse subventricular zoneSVZ neurogenic nicheNeural progenitor responseAbsence of responseSystem injuryCerebral ventricleProgenitor responseLateral ventricleNeurogenic nichePurinergic receptorsClamp recordingsExtracellular adenosineReceptorsCellular damageWidespread expressionInflammation
2004
Maitotoxin Induces Biphasic Interleukin-1β Secretion and Membrane Blebbing in Murine Macrophages
Verhoef P, Kertesy S, Estacion M, Schilling W, Dubyak G. Maitotoxin Induces Biphasic Interleukin-1β Secretion and Membrane Blebbing in Murine Macrophages. Molecular Pharmacology 2004, 66: 909-920. PMID: 15385641, DOI: 10.1124/mol.66.4.909.Peer-Reviewed Original ResearchConceptsMTX treatmentMIL-1betaIL-1betaCytolytic releaseProIL-1betaProinflammatory cytokine interleukin-1betaProinflammatory cytokine secretionCytokine interleukin-1betaMature IL-1betaMurine macrophagesInterleukin-1β secretionCytokine releaseInflammatory leukocytesCytokine secretionP2X7 receptorInterleukin-1betaInflammatory macrophagesExtracellular Ca2Extracellular glycineIntracellular Ca2Vivo responseMacrophagesCation channelsSecretionLytic phase
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