2025
Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Luo H, Anderson C, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon M, Thomas J, Gruber P, Elder R, Mak M, Riaz M, Campbell S, Qyang Y. Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2025 PMID: 40582540, DOI: 10.1016/j.actbio.2025.06.055.Peer-Reviewed Original ResearchSingle ventricle congenital heart defectsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesCongenital heart defectsHuman umbilical arteryUmbilical arteryHeart defectsPulmonary circulationDecellularized human umbilical arteriesHeart tissueLife-threatening defectsLife-threatening disorderLong-term complicationsEngineered Heart TissueFontan surgeryFunctioning ventriclePrompt treatmentHeart failureSpontaneous beatingPump functionImprove outcomesPressure generationConventional treatment
2022
Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease
Joseph P, Systrom D. Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease. 2022, 582-596. DOI: 10.1016/b978-0-12-801238-3.11478-3.ChaptersInvasive cardiopulmonary exercise testingCardiopulmonary exercise testingPulmonary vascular diseaseArtery catheterExercise testingCardiac outputPulmonary circulationVascular diseaseNoninvasive cardiopulmonary exercise testingNormal diagnostic workupPulmonary parenchymal diseaseRight heart catheterizationPulmonary arterial hypertensionPulmonary artery catheterArterial blood gasesRadial artery catheterModern medical therapyUseful screening testFick cardiac outputMeasurements of rightArterial hypertensionHeart catheterizationPulmonary hypertensionVenous hypertensionExercise impairment
2021
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data
Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.Peer-Reviewed Original ResearchPulmonary arteryAdult male C57BL/6J miceElevated pulmonary arterial pressureChronic cardiopulmonary conditionsPulmonary arterial pressureMale C57BL/6J miceElastic pulmonary arteriesArterial pulse wave velocityPulse wave velocityPotential therapeutic targetPulmonary arterial stiffeningSmooth muscle cell phenotypeMuscle cell phenotypeSpecific transcriptomic changesArterial pressureArterial stiffeningHypoxic miceCardiopulmonary conditionsPulmonary circulationC57BL/6J miceSustained hypoxiaTherapeutic targetClinical importanceEndothelial proliferationArtery
2020
Multimodality Imaging of the Right Heart
Posada-Martinez E, Ortiz-Leon X, Sugeng L, Hur D. Multimodality Imaging of the Right Heart. Clinical Cases In Cardiology 2020, 43-70. DOI: 10.1007/978-3-030-38662-7_3.ChaptersRight ventricleExtent of diseaseInvasive treatment optionQuality of lifePeriprocedural planningPatient selectionRight heartCardiac statusPathophysiologic impactTricuspid valveTreatment optionsPulmonary circulationMultimodality imagingRight sideVentricleTissue characterizationHeartMorbidityPrognosisMortalityDisease
2019
Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2019, 102: 220-230. PMID: 31634626, PMCID: PMC7227659, DOI: 10.1016/j.actbio.2019.10.019.Peer-Reviewed Original ResearchConceptsSingle-ventricle cardiac defectsHuman umbilical arteryPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesFontan procedureSurgical interventionSVD patientsCell-derived cardiomyocytesFontan conduitTherapeutic potentialEngineered Heart TissueVascular conduitsCongenital disorderDesign strategyVariety of complicationsEfficient electrical conductivitySingle ventricle heartPrimary cardiac fibroblastsFontan circulationHeart failureCorrective surgeryUmbilical arteryPulmonary circulationBiodegradable materialsPulmonary systemNon-invasive Multimodality Cardiovascular Imaging of the Right Heart and Pulmonary Circulation in Pulmonary Hypertension
Hur DJ, Sugeng L. Non-invasive Multimodality Cardiovascular Imaging of the Right Heart and Pulmonary Circulation in Pulmonary Hypertension. Frontiers In Cardiovascular Medicine 2019, 6: 24. PMID: 30931315, PMCID: PMC6427926, DOI: 10.3389/fcvm.2019.00024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMean pulmonary arterial pressureRight heart catheterizationPulmonary hypertensionRight ventricleEvaluation of PHMultimodality cardiovascular imagingPulmonary arterial pressurePulmonary arterial vasculatureNon-invasive imaging methodMillimeters of mercuryHeart catheterizationArterial pressurePrognostic riskRight heartNon-invasive imagingPatient survivalRV structurePulmonary circulationSeverity stratificationEarly initiationArterial vasculatureFunctional assessmentMortality rateRH dysfunctionTreatment management
2017
Preliminary Design and Testing of a Cavo-Arterial Pump Utilizing Axial Magnetic Couplings
Valdovinos J, Bouwmeester J, Bonde P. Preliminary Design and Testing of a Cavo-Arterial Pump Utilizing Axial Magnetic Couplings. Journal Of Medical Devices 2017, 12: 011001. DOI: 10.1115/1.4038221.Peer-Reviewed Original ResearchRight ventricular assist deviceCirculatory supportMechanical circulatory support therapyAdequate circulatory supportRight ventricular dysfunctionHeart failure patientsPartial circulatory supportVentricular assist deviceIntravascular pumpVentricular dysfunctionFailure patientsSupport therapyPulmonary circulationPulmonary supportAssist deviceExtensive operationsAxial magnetic couplingBlood contactTorque transmissionDrive mechanismContactless torque transmissionHgDirect drive mechanismMagnetic drive mechanismMaximum pressure difference
2016
Transcatheter valve implantation for right atrium‐to‐right ventricle conduit obstruction or regurgitation after modified Björk–fontan procedure
Shah AH, Horlick EM, Eicken A, Asnes JD, Bocks ML, Boudjemline Y, Cabalka AK, Fagan TE, Schubert S, Mahadevan VS, Dvir D, Osten M, McElhinney DB. Transcatheter valve implantation for right atrium‐to‐right ventricle conduit obstruction or regurgitation after modified Björk–fontan procedure. Catheterization And Cardiovascular Interventions 2016, 89: 298-305. PMID: 27465501, DOI: 10.1002/ccd.26648.Peer-Reviewed Original ResearchMeSH KeywordsAdultBioprosthesisBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCanadaCardiac CatheterizationEuropeFemaleFontan ProcedureGraft Occlusion, VascularHeart Defects, CongenitalHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansMaleMiddle AgedNorth AmericaProsthesis DesignProsthesis FailureRecovery of FunctionRegistriesRetrospective StudiesStentsTime FactorsTreatment OutcomeConceptsRight ventricleBjörk modificationFontan procedureValve implantationExtra-anatomic graftRetrospective multicenter registrySapien valve implantationLow procedural riskTranscatheter valve implantationRight atrial appendageCardiovascular causesPercutaneous transcatheterRA-RVUncomplicated implantationMulticenter registrySAPIEN 3Clinical improvementValve dysfunctionConduit dysfunctionFontan circulationPulmonary circulationAtrial appendageFontan pathwayTranscatheter implantationProcedural risk
2015
Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease
Singh I, Cong K, Berlin DA. Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease. The American Journal Of Medicine 2015, 129: 366-371. PMID: 26706386, DOI: 10.1016/j.amjmed.2015.11.026.Peer-Reviewed Original ResearchConceptsLung disease-associated pulmonary hypertensionChronic obstructive pulmonary diseaseObstructive pulmonary diseasePulmonary hypertensionLung diseasePulmonary diseaseChronic parenchymal lung diseaseNormal pulmonary circulationChronic lung diseaseIdiopathic pulmonary fibrosisInterstitial lung diseaseParenchymal lung diseasePulmonary fibrosisWorse prognosisPathophysiological factorsPulmonary circulationHypertensionDiseasePathophysiologyPhysiological determinantsSarcoidosisPrognosisFibrosis
2014
Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice
Das M, Boerma M, Goree JR, Lavoie EG, Fausther M, Gubrij IB, Pangle AK, Johnson LG, Dranoff JA. Pathological Changes in Pulmonary Circulation in Carbon Tetrachloride (ccl4)-Induced Cirrhotic Mice. PLOS ONE 2014, 9: e96043. PMID: 24763616, PMCID: PMC3999097, DOI: 10.1371/journal.pone.0096043.Peer-Reviewed Original ResearchConceptsPulmonary acceleration timeCirrhotic micePortopulmonary hypertensionPulmonary circulationPathological changesSpleen weight/body weight ratioVentricle weight/body weightWeight/body weight ratioChronic CCl4 treatmentPulmonary vascular diseaseMale C57BL/6 miceBody weight ratioTimes/weekOxidative stress markersNovel therapeutic interventionsPicrosirius red stainingSterile olive oilPortal hypertensionEffects of CCl4Pulmonary arteryC57BL/6 micePathophysiological mechanismsPulmonary vasculaturePerivascular collagenVascular disease
2011
Short-Term Performance of the Transcatheter Melody Valve in High-Pressure Hemodynamic Environments in the Pulmonary and Systemic Circulations
Hasan BS, McElhinney DB, Brown DW, Cheatham JP, Vincent JA, Hellenbrand WE, Jones TK, Zahn EM, Lock JE. Short-Term Performance of the Transcatheter Melody Valve in High-Pressure Hemodynamic Environments in the Pulmonary and Systemic Circulations. Circulation Cardiovascular Interventions 2011, 4: 615-620. PMID: 22075926, DOI: 10.1161/circinterventions.111.963389.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgedAortic ValveBlood CirculationCardiac CatheterizationChild, PreschoolFollow-Up StudiesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansInfantMitral ValvePulmonary CirculationPulmonary ValveRegional Blood FlowRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Dysfunction, RightYoung AdultConceptsMelody valveDysfunctional right ventricular outflow tractsUS Investigational Device Exemption TrialInvestigational device exemption trialPercutaneous pulmonary valve replacementRight ventricular outflow tractProcedure-related deathsPulmonary valve replacementGood valve functionVentricular outflow tractShort-term resultsValve replacementSevere regurgitationMild regurgitationPulmonary circulationSevere stenosisOutflow tractInclusion criteriaCatheterization laboratorySystemic circulationValve functionAortic implantsRegurgitationPatientsImplants
1999
Portal hypertension
Garcia-Tsao G. Portal hypertension. Current Opinion In Gastroenterology 1999, 15: 260-269. PMID: 17023954, DOI: 10.1097/00001574-199905000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsComplications of cirrhosisPortal hypertensionHyperdynamic circulationHepatic insufficiencyChronic liver diseaseRenal vasoconstrictionSinusoidal hypertensionGastroesophageal varicesHepatopulmonary syndromePeripheral vasodilatationHemodynamic abnormalitiesPortosystemic encephalopathyLiver diseaseSodium retentionPulmonary circulationNeurohumoral systemsCirrhosisHypertensionMajor syndromesVasodilatationSyndrome resultsComplicationsEnd stageSyndromeInsufficiency
1995
955-58 Intracardiac Echocardiographic Quantification and Monitoring of Myocardial Perfusion Defects and Reperfusion with the Use of Intravenous Injection of FS069, a Transpulmonic Contrast Agent
Schwartz S, Cao Q, Delabays A, Sugeng L, Pandian N. 955-58 Intracardiac Echocardiographic Quantification and Monitoring of Myocardial Perfusion Defects and Reperfusion with the Use of Intravenous Injection of FS069, a Transpulmonic Contrast Agent. Journal Of The American College Of Cardiology 1995, 25: 204a-205a. DOI: 10.1016/0735-1097(95)92307-q.Peer-Reviewed Original ResearchWall motion abnormalitiesIntracardiac echocardiographyPerfusion defectsEpisodes of ischemiaLV cavityRegional wall motion abnormalitiesMyocardial perfusion defectsIntracardiac echocardiography imagingShort-axis viewMotion abnormalitiesPulmonary circulationEchocardiographic quantificationPerfusion statusIntravenous injectionIV injectionMyocardial perfusionFemoral veinMyocardial hypoperfusionSmall dosesLV circumferenceCoronary arteryRV cavityLVIschemiaEndocardial border
1984
Functional assessment of the pulmonary microcirculation during postnatal development.
Lister G, Kopf G, Pitt B. Functional assessment of the pulmonary microcirculation during postnatal development. Neonatology 1984, 4: 85-99. PMID: 6091021.Peer-Reviewed Original Research
1981
The Pathophysiology of disorders of oxygen transport in the infant
Talner N, Lister G. The Pathophysiology of disorders of oxygen transport in the infant. Current Problems In Pediatric And Adolescent Health Care 1981, 11: 7-50. PMID: 7226876, DOI: 10.1016/0045-9380(81)90037-2.Peer-Reviewed Original ResearchConceptsPathophysiology of disordersLower airwaysSurgical treatmentClinical presentationPathophysiologic mechanismsPulmonary circulationHematologic systemLung parenchymaOxygen deliveryPathologic processesControl of respirationOrgan systemsOxygen uptakeLungInfantsTissueDisordersSupply of oxygenHeartAdaptive responseCirculationAirwayPathophysiologyLesionsOxygen transport
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