2025
β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation
Uribe S, Shany E, Zhang Y, Wu A, Dan W, Perez-Zoghbi J, Emala C, Yim P. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l526-l537. PMID: 39937635, DOI: 10.1152/ajplung.00227.2024.Peer-Reviewed Original ResearchConceptsAirway smooth muscle relaxationOpsin 3Severity of asthma exacerbationsAirway smooth muscle cellsDose-dependent relaxationTherapeutic agentsAirways in vitroPrecision-cut lung slicesSmooth muscle relaxationSmooth muscle cellsAttenuated relaxationWire myographyDietary intakeDecreased relaxationAirway pathologyIncreased riskReceptor activationAsthma exacerbationsMuscle cellsLower airwaysLung slicesMRNA expressionMuscle relaxationTracheal ringsAirway
2023
Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2
Murphy T, Kirkham C, D’Mello A, Sethi S, Pettigrew M, Tettelin H. Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2. MBio 2023, 14: e00140-23. PMID: 36927061, PMCID: PMC10127715, DOI: 10.1128/mbio.00140-23.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseNontypeable Haemophilus influenzaeObstructive pulmonary diseaseRespiratory epithelial cellsHuman airwaysHaemophilus influenzaeAirway inflammationLung functionMechanisms of persistencePulmonary diseaseEpithelial cellsNovel interventionsChronic lower airway infectionsProgressive lossAirways of adultsLower airway infectionHuman respiratory epithelial cellsCommon debilitating disorderStrains of NTHiNTHi infectionAirway infectionLower airwaysCommon causeSequential isolatesSerial isolates
2019
Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion
Ahearn C, Kirkham C, Chaves L, Kong Y, Pettigrew M, Murphy T. Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion. Infection And Immunity 2019, 87: 10.1128/iai.00462-19. PMID: 31427451, PMCID: PMC6803334, DOI: 10.1128/iai.00462-19.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseRespiratory epithelial cellsEnzyme-linked immunosorbent assayEpithelial cellsAirways of adultsObstructive pulmonary diseaseCell invasionHuman respiratory epithelial cellsNontypeable Haemophilus influenzaeCell enzyme-linked immunosorbent assayAlveolar epithelial cellsAcute exacerbationLower airwaysPulmonary diseaseSerum IgGNTHi strainsTherapeutic interventionsHaemophilus influenzaeHuman bronchialSurface-exposed epitopesEpithelial cell invasionIsogenic knockout mutantsNTHiImmunosorbent assayIntracellular survivalLC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
Wisnewski AV, Liu J, Nassar AF. LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate. 2019, 7: 205-219. PMID: 31143884, PMCID: PMC6536005.Peer-Reviewed Original Research
2018
Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Gallo MC, Kirkham C, Eng S, Bebawee RS, Kong Y, Pettigrew MM, Tettelin H, Murphy TF. Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Infection And Immunity 2018, 86: 10.1128/iai.00313-18. PMID: 29760213, PMCID: PMC6056860, DOI: 10.1128/iai.00313-18.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePersistent infectionPulmonary diseaseIgA proteaseProtease expressionNontypeable Haemophilus influenzaeAcute exacerbationLower airwaysRespiratory tractNTHi strainsHaemophilus influenzaeInfectionNTHiNatural infectionHuman pathobiontAltered expressionPatientsDiseasePersistent strainsExpressionCritical roleExacerbationAirwayInitial acquisition
2017
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Wisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.Peer-Reviewed Original ResearchConceptsCollision-induced dissociation (CID) fragmentation patternsReaction productsLower airwaysChemical reactivityLow molecular weight fractionWeight fractionHigh molecular weight fractionAliphatic diisocyanateMolecular weight fractionFragmentation patternsHexamethylenediisocyanateLC-MSHDI vaporAirways of rabbitsBronchoalveolar lavage fluidRabbit bronchoalveolar lavage fluidMoleculesDiisocyanate vaporsMs. 4Albumin. 5Occupational asthmaReactivityBAL fluidAsthma pathogenesisLavage fluid
2015
Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situ
Wisnewski AV, Liu J. Immunochemical detection of the occupational allergen, methylene diphenyl diisocyanate (MDI), in situ. Journal Of Immunological Methods 2015, 429: 60-65. PMID: 26690039, PMCID: PMC4753098, DOI: 10.1016/j.jim.2015.12.008.Peer-Reviewed Original ResearchConceptsKeyhole limpet hemocyaninFreund's adjuvantDiisocyanate-induced asthmaComplete Freund's adjuvantIncomplete Freund's adjuvantLung tissue sectionsFormalin-fixed paraffinOccupational asthmaLower airwaysBooster injectionOccupational allergensAirway cellsAlveolar macrophagesLimpet hemocyaninAdjuvantHealth effectsTissue distributionTissue samplesTissue sectionsAsthmaDot blot analysisFurther studiesImmunochemical studiesBlot analysisEpithelial regions
2013
Exercise-Induced Bronchoconstriction and Vocal Cord Dysfunction
Rundell KW, Weiss P. Exercise-Induced Bronchoconstriction and Vocal Cord Dysfunction. Current Sports Medicine Reports 2013, 12: 45-50. PMID: 23314083, DOI: 10.1249/jsr.0b013e318281e471.Peer-Reviewed Original ResearchConceptsExercise-induced bronchoconstrictionVocal cord dysfunctionCord dysfunctionBronchial smooth muscle constrictionExercise-induced dyspneaSmooth muscle constrictionCessation of exerciseSelf-reported symptomsPersistent asthmaInspiratory stridorLower airwaysExercise cessationParadoxical adductionMuscle constrictionCommon causeAirway cellsSame patientVocal cordsChallenge testPatientsDyspneaBronchoconstrictionAsthmaDysfunctionInhalation
2007
Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis
Treggiari MM, Rosenfeld M, Retsch‐Bogart G, Gibson R, Ramsey B. Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis. Pediatric Pulmonology 2007, 42: 751-756. PMID: 17647287, DOI: 10.1002/ppul.20665.Peer-Reviewed Original ResearchConceptsAnti-pseudomonal antibioticsCystic fibrosisEarly interventionInitial Pseudomonas aeruginosa infectionSafe treatment regimenObstructive lung diseasePseudomonas aeruginosa infectionChronic endobronchial infectionLower airwaysTreatment regimenEndobronchial infectionClinical benefitLarge trialsLung diseaseAeruginosa infectionPA isolatesYoung childrenPa acquisitionFibrosisInfectionChildrenPrimary causePseudomonas aeruginosaWindow of opportunityEradication
1998
Effects of rate and amplitude of breathing on respiratory system elastance and resistance during growth of healthy children
Galal M, Habib R, Jaeger D, Lister G. Effects of rate and amplitude of breathing on respiratory system elastance and resistance during growth of healthy children. Pediatric Pulmonology 1998, 25: 270-277. PMID: 9590487, DOI: 10.1002/(sici)1099-0496(199804)25:4<270::aid-ppul7>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsChest wall tissuesHealthy childrenHigh inspiratory flow ratesHigh VTRespiratory system elastanceAirway opening pressureRespiratory system resistanceInspiratory flow rateWall tissuePressure-volume relationshipLower airwaysLung diseaseLung growthHealthy subjectsTidal volumeTracheal pressureRespiratory tissuesBreathing frequencyOpening pressure
1981
The Pathophysiology of disorders of oxygen transport in the infant
Talner N, Lister G. The Pathophysiology of disorders of oxygen transport in the infant. Current Problems In Pediatric And Adolescent Health Care 1981, 11: 7-50. PMID: 7226876, DOI: 10.1016/0045-9380(81)90037-2.Peer-Reviewed Original ResearchConceptsPathophysiology of disordersLower airwaysSurgical treatmentClinical presentationPathophysiologic mechanismsPulmonary circulationHematologic systemLung parenchymaOxygen deliveryPathologic processesControl of respirationOrgan systemsOxygen uptakeLungInfantsTissueDisordersSupply of oxygenHeartAdaptive responseCirculationAirwayPathophysiologyLesionsOxygen transport
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