2022
Kappa opioid receptor antagonism protects working memory performance from mild stress exposure in Rhesus macaques
Wallace T, Martin W, Arnsten A. Kappa opioid receptor antagonism protects working memory performance from mild stress exposure in Rhesus macaques. Neurobiology Of Stress 2022, 21: 100493. PMID: 36532373, PMCID: PMC9755019, DOI: 10.1016/j.ynstr.2022.100493.Peer-Reviewed Original ResearchKappa-opioid receptorsKOR systemKappa opioid receptor antagonismNeurobehavioral disordersStress exposureSelective KOR antagonistOpioid receptor antagonismClinical evidence pointsBenzodiazepine inverse agonistStress-induced dysfunctionMild stress exposureKOR antagonistsReceptor antagonismMesocortical pathwayOpioid receptorsTherapeutic benefitKOR activityInverse agonistKOR expressionReceptor systemRhesus macaquesMild stress responseBrain networksEvidence pointsFunctional influence
2020
Cutting-edge genetics in obsessive-compulsive disorder
Saraiva L, Cappi C, Simpson H, Stein D, Viswanath B, van den Heuvel O, Reddy Y, Miguel E, Shavitt R. Cutting-edge genetics in obsessive-compulsive disorder. Faculty Reviews 2020, 9: 30. PMID: 33659962, PMCID: PMC7886082, DOI: 10.12703/r/9-30.Peer-Reviewed Original ResearchGenetic architectureWide association studyNumber variation studiesCutting-edge geneticsWhole-exome sequencing studiesUnderlying biological pathwaysHuman cell modelsGene networksStudy of endophenotypesGene expressionBiological pathwaysSequencing studiesAssociation studiesAnimal systemsGeneticsGene-environment interactionsCell modelBiological basisPolygenic risk scoresEvidence pointsSynaptic transmissionRecent advancesVariation studiesExperimental animal systemsNeuropsychiatric disordersmTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Karam BS, Morris RS, Bramante CT, Puskarich M, Zolfaghari EJ, Lotfi‐Emran S, Ingraham NE, Charles A, Odde DJ, Tignanelli CJ. mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses. Journal Of Medical Virology 2020, 93: 1843-1846. PMID: 33314219, PMCID: PMC8159020, DOI: 10.1002/jmv.26728.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus 2 infectionReview of efficacyCoronavirus disease 2019Modulation of mTORSARS-CoV-2RNA virusesDisease 2019Recent evidence pointsMTOR inhibitorsViral infectionMTOR inhibitionMTOR pathwayMammalian targetRapamycin (mTOR) pathwayNumerous RNA virusesVirus growthCOVID-19MTOR resultsInfectionCurrent literatureHighlight evidenceEvidence points
2019
Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”. Human Genomics 2019, 13: 11. PMID: 30782214, PMCID: PMC6381713, DOI: 10.1186/s40246-019-0191-9.Peer-Reviewed Original ResearchConceptsMajor urinary protein genesKingdoms of lifeLipocalin gene familyGene familyMUP genesMouse genomeHuman genomeProtein geneChromosome 4Regulation of glucoseBarrel structurePhysiological processesΒ-strandsPhysiological functionsSecretory tissueGenesScent marksPseudogenesGenomeLipid metabolismBloomsEvidence pointsSyntenicImportant roleSteroid hormones
2018
Polycystin-2-dependent control of cardiomyocyte autophagy
Criollo A, Altamirano F, Pedrozo Z, Schiattarella GG, Li DL, Rivera-Mejías P, Sotomayor-Flores C, Parra V, Villalobos E, Battiprolu PK, Jiang N, May HI, Morselli E, Somlo S, de Smedt H, Gillette TG, Lavandero S, Hill JA. Polycystin-2-dependent control of cardiomyocyte autophagy. Journal Of Molecular And Cellular Cardiology 2018, 118: 110-121. PMID: 29518398, DOI: 10.1016/j.yjmcc.2018.03.002.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseIntracellular CaCardiomyocyte autophagyAutophagic fluxBAPTA-AMDominant polycystic kidney diseaseStress-induced autophagySarcoplasmic reticulum CaPolycystic kidney diseasePolycystin-2Impaired autophagic fluxKidney diseaseKnockout miceConsiderable evidence pointsMTOR inhibitionReticulum CaExtracellular CaMultiple cell typesAutophagic activityAutophagy inductionHomeostasisAutophagyEvidence pointsAutophagic controlCell types
2017
Psychotherapy for the Spectrum of Sexual Minority Stress: Application and Technique of the ESTEEM Treatment Model
Burton CL, Wang K, Pachankis JE. Psychotherapy for the Spectrum of Sexual Minority Stress: Application and Technique of the ESTEEM Treatment Model. Cognitive And Behavioral Practice 2017, 26: 285-299. PMID: 31592215, PMCID: PMC6779338, DOI: 10.1016/j.cbpra.2017.05.001.Peer-Reviewed Original ResearchNegative psychosocial health outcomesPsychosocial health outcomesRisk factorsTherapeutic principlesHealth outcomesSubstance useMinority stressPsychoeducation contentTherapeutic modelTreatment modelSexual minority stressEvidence pointsMinority stress processesTransdiagnostic mechanismsOutcomesSexual minority individualsEarly stages
2015
Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB)
Liang S, Yokell D, Jackson R, Rice P, Livni E, Alagille D, Tamagnan G, Collier T, Vasdev N. Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB). 2015, 41-51. DOI: 10.1002/9781118834114.ch5.Peer-Reviewed Original ResearchMetabotropic glutamate receptor subtype 5Regional brain concentrationsHealthy human subjectsBrain concentrationsBrain penetranceMGluR5 antagonistSubtype 5Parkinson's diseasePathologic processesAlzheimer's diseaseNeuropsychiatric disordersNeurodegenerative diseasesDiseaseHigh potencyHuman subjectsEvidence pointsFragile X syndromeControl testsRadiochemical purityCritical roleX syndromeMGluR5SyndromeAntagonistAbnormalities
2012
Spectraplakins: Master orchestrators of cytoskeletal dynamics
Suozzi KC, Wu X, Fuchs E. Spectraplakins: Master orchestrators of cytoskeletal dynamics. Journal Of Cell Biology 2012, 197: 465-475. PMID: 22584905, PMCID: PMC3352950, DOI: 10.1083/jcb.201112034.Peer-Reviewed Original ResearchConceptsCytoskeletal networkFundamental cellular processesDifferent cytoskeletal networksMaster orchestratorCytoskeletal dynamicsCellular processesCell divisionSplice formsMultiple promotersDistinct functionsSpectraplakinsF-actinCell migrationIntermediate filamentsVast arrayRecent studiesEvidence pointsCytoskeletalCytoskeletonExonsGenesPromoterSpectrinMicrotubulesFilaments
2010
Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences
Taylor S, Wagner C, Hollis B. Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences. Nutrition And Health 2010, 615-631. DOI: 10.1007/978-1-60327-303-9_32.Commentaries, Editorials and LettersVitamin D deficiencyVitamin DHealth statusD deficiencyBone healthImmune functionMaternal vitamin D supplementationVitamin D sufficiencyVitamin D supplementationVitamin D statusPregnancy-related diseasesVitamin D functionD supplementationD statusD sufficiencyGlucose toleranceLong-term effectsEpidemic proportionsPregnancyHealth consequencesEarly lifeCell proliferationInfantsEvidence pointsStatus
2009
Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences
Taylor S, Wagner C, Hollis B. Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences. Clinical & Translational Metabolism 2009, 7: 42-51. DOI: 10.1007/s12018-009-9035-9.Commentaries, Editorials and LettersVitamin D deficiencyVitamin DHealth statusD deficiencyBone healthImmune functionMaternal vitamin D supplementationVitamin D sufficiencyVitamin D supplementationVitamin D statusPregnancy-related diseasesVitamin D functionD supplementationD statusD sufficiencyGlucose toleranceLong-term effectsEpidemic proportionsPregnancyHealth consequencesEarly lifeCell proliferationInfantsEvidence pointsStatus
2008
Fuel utilization by hypothalamic neurons: roles for ROS
Horvath TL, Andrews ZB, Diano S. Fuel utilization by hypothalamic neurons: roles for ROS. Trends In Endocrinology And Metabolism 2008, 20: 78-87. PMID: 19084428, DOI: 10.1016/j.tem.2008.10.003.Peer-Reviewed Original ResearchConceptsEnergy homeostasisFree radical productionAnorexigenic neuronsNeuronal doctrineArcuate nucleusHypothalamic neuronsHypothalamic outputMelanocortin systemEffect of glucoseNeuronal functionFree radical formationSpecific neuronsAcid levelsNeuronsAmino acid levelsNeurobiological aspectsRadical productionEvidence pointsFatty acidsFuel sensingIntracellular substratesHomeostasisNutritional signalsGlucoseHypothalamus
2004
Is the Party Over? Cannabis and Juvenile Psychiatric Disorder: The Past 10 Years
REY JM, MARTIN A, KRABMAN P. Is the Party Over? Cannabis and Juvenile Psychiatric Disorder: The Past 10 Years. Journal Of The American Academy Of Child & Adolescent Psychiatry 2004, 43: 1194-1205. PMID: 15381886, DOI: 10.1097/01.chi.0000135623.12843.60.Peer-Reviewed Original ResearchConceptsJuvenile psychiatric disordersPsychiatric disordersOnset of schizophreniaRole of cannabisMental health effectsRate of useRegular marijuana usePsychotic illnessDepressive symptomsRegular cannabisMental disordersSuicidal behaviorPsychosocial functioningLiterature databasesSystematic searchHealth effectsLate increaseCannabisDisordersAdolescent dataBehavioral problemsRecent dataMarijuana useCannabis researchEvidence points
2000
Aging, methylation and cancer.
Ahuja N, Issa JP. Aging, methylation and cancer. Histology And Histopathology 2000, 15: 835-42. PMID: 10963127, DOI: 10.14670/hh-15.835.Peer-Reviewed Original ResearchConceptsAge-related methylationSuch age-related methylationPromoter-associated CpG islandsTumor suppressor geneGene functionDNA methylationCpG islandsMethylation changesFull methylationGene expressionMethylationGenesNovel targetNormal cellsColon cancerAlternate mechanismMost cancersEvidence pointsFundamental markMyoDIGF2HypermethylationDNAERMutations
1994
Protein tyrosine phosphatases in the nervous system.
Naegele J, Lombroso P. Protein tyrosine phosphatases in the nervous system. Critical Reviews In Neurobiology 1994, 9: 105-14. PMID: 8828006.Peer-Reviewed Original ResearchConceptsGrowth factor receptor signaling cascadesTyrosine kinaseReceptor signaling cascadesRole of PTPsNervous systemProtein tyrosineNeuronal developmentLevels of phosphotyrosineBrainEvidence pointsSignaling cascadesFunctional roleTyrosine phosphataseLocalization patternsNeurotransmittersImportant role
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