2025
Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions.
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of AD-vulnerable regions. Journal Of Clinical Sleep Medicine 2025 PMID: 40110600, DOI: 10.5664/jcsm.11630.Peer-Reviewed Original ResearchRapid eye movementSlow wave sleepSleep architectureArousal indexAssociated with smaller volumesCerebral microbleedsLobar cerebral microbleedsProportion of rapid eye movementBaseline sleep architectureRapid eye movement sleepProportion of slow wave sleepAssociated with cerebral microbleedsEye movement sleepSleep architecture variablesModifiable risk factorsAtrophy of hippocampusSleep deficiencyMedian ageParietal regionsMovement sleepMRI outcomesAssociated with brain atrophyAnatomical featuresRisk factorsCuneus regions
2024
Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e093827. PMCID: PMC11713325, DOI: 10.1002/alz.093827.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepLower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e089369. PMCID: PMC11716384, DOI: 10.1002/alz.089369.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepEntropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping – A Preliminary Report
Rao N, Paek A, Contreras-Vidal J, Parikh P. Entropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping – A Preliminary Report. Journal Of Motor Behavior 2024, 56: 665-677. PMID: 39056321, PMCID: PMC11449659, DOI: 10.1080/00222895.2024.2373241.Peer-Reviewed Original ResearchMaximum voluntary contractionGrip force controlIsometric force control tasksHealthy young adultsNeural processesGrip forceGrip force magnitudeParietal electrodesParietal regionsContralateral hemisphereWithin-trialNeural variabilityEEG variablesControl taskForce control taskNeural entropyStudy investigated roleYoung adultsForce magnitudeVoluntary contractionElectroencephalography activityCentral electrodeElectroencephalographyNoninvasive electroencephalographyTrialsA new transfer entropy method for measuring directed connectivity from complex-valued fMRI data
Li W, Lin Q, Zhang C, Han Y, Calhoun V. A new transfer entropy method for measuring directed connectivity from complex-valued fMRI data. Frontiers In Neuroscience 2024, 18: 1423014. PMID: 39050665, PMCID: PMC11266018, DOI: 10.3389/fnins.2024.1423014.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFMRI dataBrain regionsAnatomical Automatic LabelingTransfer entropyFunctional magnetic resonance imaging dataConnectivity of brain regionsFrontal-parietal regionsConsistent with previous findingsSignificant group differencesRight frontal-parietal regionPartial transfer entropyPredicting mental disordersMental disordersParietal regionsGroup differencesMagnitude effectExperimental fMRI dataDirectional connectivityComplex-valued fMRI dataSchizophreniaMagnetic resonance imagingComplex-valued approachEntropyMagnitude data
2023
EEG coherence before and after giving birth
Sandoval I, Ngoh G, Wu J, Crowley M, Rutherford H. EEG coherence before and after giving birth. Brain Research 2023, 1816: 148468. PMID: 37336317, DOI: 10.1016/j.brainres.2023.148468.Peer-Reviewed Original ResearchConceptsPostpartum periodEEG coherenceParietal regionsIntrahemispheric EEG coherenceInterhemispheric EEG coherenceMaternal brainMonths postpartumNeurophysiological changesBrain volumeCortical couplingFrontopolar regionNeural circuitsBrain functionPregnancyElectroencephalographic coherenceAlphaBetaEmotional processesLongitudinal modificationsPostpartumBrainTwo different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary
Palomar-García M, Villar-Rodríguez E, Pérez-Lozano C, Sanjuán A, Bueichekú E, Miró-Padilla A, Costumero V, Adrián-Ventura J, Parcet M, Ávila C. Two different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary. Brain And Language 2023, 237: 105231. PMID: 36716643, DOI: 10.1016/j.bandl.2023.105231.Peer-Reviewed Original ResearchConceptsLanguage control networkPicture naming taskOld wordsNaming TaskMeasured BOLD signal changesControl networkBOLD signal changesNative wordsPicture namingBrain networksSpanish wordsParietal regionsCortical networksCortical/subcortical networksHealthy participantsActivity patternsFunctional circuitsWordsSignal changesVocabularyTaskCognitive purposesFMRILanguageHippocampus
2022
Neural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2020
Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity
Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. Journal Of Cognitive Neuroscience 2020, 33: 499-509. PMID: 33284079, PMCID: PMC8826533, DOI: 10.1162/jocn_a_01658.Peer-Reviewed Original ResearchConceptsAssociated with lower DTStudies of creative cognitionField of cognitive neuroscienceComputational semantic modelsSample of healthy adultsMeasuring creative performanceLevels of DTRight inferior occipitalFunctional brain networksResting-state networksResting-state imagingSemantic distanceVisual temporalLow DTCognitive neuroscienceNeural basisCreative cognitionGeneration of novel ideasTemporal cortexInferior occipitalBrain networksParietal regionsGray matter voxelsConnectivity decreaseVisual regionsDistributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals
Avery EW, Yoo K, Rosenberg MD, Greene AS, Gao S, Na DL, Scheinost D, Constable TR, Chun MM. Distributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals. Journal Of Cognitive Neuroscience 2020, 32: 241-255. PMID: 31659926, PMCID: PMC8004893, DOI: 10.1162/jocn_a_01487.Peer-Reviewed Original ResearchConceptsFunctional connectivity patternsFluid intelligenceMemory performanceIndividual differencesAttention modelConnectome-based predictive modelingConnectome-based predictive modelsWhole-brain functional connectivity patternsGeneral cognitive abilitySuch individual differencesConnectivity patternsAdult life spanHuman Connectome ProjectHuman Connectome Project dataMemory relateCognitive abilitiesNeural basisSustained attentionMemory scoresParietal regionsFunctional connectivityConnectome ProjectMemory modelOlder adultsMemory
2019
Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures
Chiosa V, Ciolac D, Groppa S, Koirala N, Pintea B, Vataman A, Winter Y, Gonzalez-Escamilla G, Muthuraman M, Groppa S. Large-scale network architecture and associated structural cortico-subcortical abnormalities in patients with sleep/awake-related seizures. Sleep 2019, 42: zsz006. PMID: 30753617, DOI: 10.1093/sleep/zsz006.Peer-Reviewed Original ResearchConceptsAwake seizuresSleep seizuresHealthy controlsAwake stateSex-matched healthy controlsRight middle temporal cortexDifferent epilepsy typesVolume of hippocampusBrain networksMiddle temporal cortexEpilepsy typePathophysiological alterationsSubcortical abnormalitiesPatientsTemporal cortexSeizuresSubcortical regionsSuperior temporalBilateral insulaOrbitofrontal cortexSleepParietal regionsAbnormalitiesRight hemisphereStructural correlates
2016
Neuroanatomy accounts for age-related changes in risk preferences
Grubb MA, Tymula A, Gilaie-Dotan S, Glimcher PW, Levy I. Neuroanatomy accounts for age-related changes in risk preferences. Nature Communications 2016, 7: 13822. PMID: 27959326, PMCID: PMC5159889, DOI: 10.1038/ncomms13822.Peer-Reviewed Original ResearchConceptsRight posterior parietal cortexGray matter volumeRisky rewardMatter volumeAge-related changesLess grey matter volumePosterior parietal cortexAge-related declineRisk preferencesNeural mechanismsRisky choiceParietal regionsParietal cortexSubstantial empirical evidenceOlder adultsHealthy agingYoung adultsRewardGray matter lossEmpirical evidencePotential outcomesHuman agingAdultsPreferencesNeuroanatomySampling over Nonuniform Distributions: A Neural Efficiency Account of the Primacy Effect in Statistical Learning
Karuza EA, Li P, Weiss DJ, Bulgarelli F, Zinszer BD, Aslin RN. Sampling over Nonuniform Distributions: A Neural Efficiency Account of the Primacy Effect in Statistical Learning. Journal Of Cognitive Neuroscience 2016, 28: 1484-1500. PMID: 27315265, PMCID: PMC5576997, DOI: 10.1162/jocn_a_00990.Peer-Reviewed Original ResearchConceptsPrimacy effectFamiliar languageExtensive behavioral evidenceEarly auditory cortexLanguage learning capacityImportance of cuesPosterior parietal regionsAbsence of cuesFunctional connectivity analysisSuccessful knowledge acquisitionNeural accountFamiliarity judgmentsNeural efficiencyCognitive systemFMRI scanningArtificial languageBehavioral evidenceNovel languageParietal regionsStatistical learningSyllable inventoryAuditory cortexEfficiency accountConnectivity analysisLearning capacity
2014
Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study
Booij L, Soucy J, Young S, Regoli M, Gravel P, Diksic M, Leyton M, Pihl R, Benkelfat C. Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study. Journal Of Neurochemistry 2014, 131: 634-644. PMID: 25041501, DOI: 10.1111/jnc.12826.Peer-Reviewed Original ResearchConceptsMDMA polydrug usersMDMA usePolydrug usersLong-term neurotoxic effectsBrain serotonin synthesisSerotonin synthesis capacityDistal brain regionsNeurotoxicity of MDMAPositron emission tomographySynthesis capacityTracer alphaSerotonin synthesisNeurotoxic effectsPre-frontal regionsTemporal areaBrain regionsEmission tomographyCompensatory mechanismsTryptophan studiesParietal regionsMethylenedioxymethamphetamine (MDMA) useLonger durationBrainstemMDMA users
2012
Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity. PLOS Computational Biology 2012, 8: e1002441. PMID: 22479172, PMCID: PMC3315448, DOI: 10.1371/journal.pcbi.1002441.Peer-Reviewed Original ResearchConceptsFearful facesEmotional expressionBilateral middle temporal gyrusThreat-related stimuliUnattended fearful facesLarge-scale functional connectivityMultiple functional connectionsFunctional magnetic resonanceWhole-brain patternsMiddle temporal gyrusWhole-brain correlationActive research goalNeutral facesEmotion processingFear perceptionImplicit fearImplicit presentationAngular gyrusChance accuracyTemporal gyrusBrain activityFace presentationPrefrontal cortexParietal regionsFunctional connectivity
2008
The dynamics of deductive reasoning: An fMRI investigation
Rodriguez-Moreno D, Hirsch J. The dynamics of deductive reasoning: An fMRI investigation. Neuropsychologia 2008, 47: 949-961. PMID: 18835284, DOI: 10.1016/j.neuropsychologia.2008.08.030.Peer-Reviewed Original ResearchConceptsDeductive reasoningReasoning processParietal regionsEvent-related fMRISupramodal networkPrevious imaging studiesNeural correlatesFMRI investigationOccipital complexLanguage areasBilateral caudate nucleusInformation processingReasoningSecond premiseImaging studiesTraditional focusCaudate nucleusSubstantive differencesFMRISubsequent conclusionsTime courseScientific investigationPhilosophical discussionCorrelatesTime pointsCorrelates of Social Problem Solving During the First Year After Traumatic Brain Injury in Children
Hanten G, Wilde E, Menefee D, Li X, Lane S, Vasquez C, Chu Z, Ramos M, Yallampalli R, Swank P, Chapman S, Gamino J, Hunter J, Levin H. Correlates of Social Problem Solving During the First Year After Traumatic Brain Injury in Children. Neuropsychology 2008, 22: 357-370. PMID: 18444714, DOI: 10.1037/0894-4105.22.3.357.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentBrain InjuriesChi-Square DistributionChildCross-Sectional StudiesFemaleHumansInhibition, PsychologicalIntelligenceLanguageLongitudinal StudiesMagnetic Resonance ImagingMaleMemoryNeuropsychological TestsProblem SolvingRecovery of FunctionSocial BehaviorConceptsTraumatic brain injuryTBI groupSocial problem-solving skillsYears post-traumatic brain injuryOI groupSocial Problem SolvingPediatric traumatic brain injuryPost-traumatic brain injuryProblem-solving skillsSevere traumatic brain injuryBrain injuryEmotional processingStrategy taskLanguage skillsDevelopmental levelParietal regionsProblem-solving stepsCingulate regionsProblem solvingLongitudinal studyYoung childrenINS performanceChildrenDiffusion tensor imagingApparent diffusion coefficient (ADC) measures
2007
Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa
Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, Wagner A, Thornton L, Hoge J, Ziolko S, Becker C, McConaha C, Kaye W. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biological Psychiatry 2007, 61: 1090-1099. PMID: 17241616, DOI: 10.1016/j.biopsych.2006.07.018.Peer-Reviewed Original ResearchConceptsPositron emission tomographyILL ANCerebral blood flowControl womenAnorexia nervosaBlood flowReceptor activityOrbital frontal regionsDorsal raphe nucleusHealthy control womenLateral temporal lobeReceptor-specific radioligandReceptor BPRaphe nucleusPoor responseSerotonin activityTemporal lobeParietal cortexEmission tomographyReceptor functionParietal regionsWomenReceptorsFrontal regionsSignificant increase
2005
Brain imaging of serotonin after recovery from anorexia and bulimia nervosa
Kaye W, Bailer U, Frank G, Wagner A, Henry S. Brain imaging of serotonin after recovery from anorexia and bulimia nervosa. Physiology & Behavior 2005, 86: 15-17. PMID: 16102788, DOI: 10.1016/j.physbeh.2005.06.019.Peer-Reviewed Original ResearchConceptsBulimia nervosaPositron emission tomographyAnorexia nervosaReceptor functionModulation of feedingAge of onsetDegree of efficacyHomogenous presentationSerotonin pathwayGender distributionEmission tomographyBody image distortionBrain functionNew pharmacologyBrain imagingParietal regionsNervosaFood consumptionLines of evidenceSymptomsIllnessAlterationsPsychotherapy approachesPathwayFeeding behaviorMistaking a House for a Face: Neural Correlates of Misperception in Healthy Humans
Summerfield C, Egner T, Mangels J, Hirsch J. Mistaking a House for a Face: Neural Correlates of Misperception in Healthy Humans. Cerebral Cortex 2005, 16: 500-508. PMID: 16014866, DOI: 10.1093/cercor/bhi129.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyAccount of perceptionImages of housesMagnetic resonance imaging studyResonance imaging studyNeural correlatesPerceptual judgmentsInferior occipitalVisual regionsCorrect trialsIncorrect trialsRight parietal regionParietal regionsHouse imagesParahippocampal gyrusPredictive codingNormal visionPerceptionFaceMisperceptionsFFA responseImaging studiesHealthy humansGyrusConcurrent activation
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