2024
PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator
Belov V, Guehl N, Duvvuri S, Iredale P, Moon S, Dhaynaut M, Chakilam S, MacDonagh A, Rice P, Yokell D, Renger J, Fakhri G, Normandin M. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [11C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1329-1342. PMID: 38477292, PMCID: PMC11342722, DOI: 10.1177/0271678x241238820.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsReceptor occupancyNon-human primatesBinding potentialPositron emission tomographyMuscarinic acetylcholine receptorsAllosteric modulatorsNon-human primate brainM4 muscarinic acetylcholine receptorStriatal hyperdopaminergiaAcetylcholine receptorsBrain regionsCaudate nucleusTotal volume of distributionDose-dependent blockReference regionVolume of distributionPositron emission tomography imagingEmission tomographyReceptor levelsFunction of dosePET scansClinical trialsBlood-basedRhesus macaques
2023
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration
Koga S, Metrick M, Golbe L, Santambrogio A, Kim M, Soto-Beasley A, Walton R, Baker M, De Castro C, DeTure M, Russell D, Navia B, Sandiego C, Ross O, Vendruscolo M, Caughey B, Dickson D. Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathologica Communications 2023, 11: 88. PMID: 37264457, PMCID: PMC10236843, DOI: 10.1186/s40478-023-01584-z.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusFrontal gyrusConsistent with corticobasal degenerationConsistent with progressive supranuclear palsyMotor cortexCorticobasal degenerationProgressive supranuclear palsyPosterior cortical areasPresentation of corticobasal degenerationSubtype of frontotemporal lobar degenerationRichardson's syndromeBrain regionsOccipital cortexSubcortical structuresCaudate nucleusFrontotemporal lobar degenerationTau PET scansSubstantia nigraGlobus pallidusCorticobasal syndromeGyrusSupranuclear palsyCortexCortical areasClinical presentation of progressive supranuclear palsyBrain volumetrics differ by Fiebig stage in acute HIV infection
Bolzenius J, Sacdalan C, Ndhlovu L, Sailasuta N, Trautmann L, Tipsuk S, Crowell T, Suttichom D, Colby D, Phanuphak N, Chan P, Premeaux T, Kroon E, Vasan S, Hsu D, Valcour V, Ananworanich J, Robb M, Ake J, Pohl K, Sriplienchan S, Spudich S, Paul R. Brain volumetrics differ by Fiebig stage in acute HIV infection. AIDS 2023, 37: 861-869. PMID: 36723491, PMCID: PMC10079583, DOI: 10.1097/qad.0000000000003496.Peer-Reviewed Original ResearchConceptsAcute HIV infectionNucleus accumbensFiebig stagesAcute infectionHIV infectionCaudate nucleusBrain volumeLower regional brain volumesAntiretroviral therapy initiationMarkers of neuroinflammationBrain volume alterationsCross-sectional studyRegional brain volumesT1-weighted scansTherapy initiationChronic infectionBrain volumetricsBrain disruptionThai malesViral factorsPutamenVolume alterationsAccumbensInfectionStimulant use
2022
Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium
Fouche J, Groenewold N, Sevenoaks T, Heany S, Lochner C, Alonso P, Batistuzzo M, Cardoner N, Ching C, de Wit S, Gutman B, Hoexter M, Jahanshad N, Kim M, Kwon J, Mataix‐Cols D, Menchon J, Miguel E, Nakamae T, Phillips M, Pujol J, Sakai Y, Yun J, Soriano‐Mas C, Thompson P, Yamada K, Veltman D, van den Heuvel O, Stein D. Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium. Brain And Behavior 2022, 12: e2755. PMID: 36106505, PMCID: PMC9575597, DOI: 10.1002/brb3.2755.Peer-Reviewed Original ResearchConceptsCaudate nucleusHealthy controlsOCD patientsComorbid depressionMedication statusComorbid anxietySubcortical shapeSignificant differencesDeep gray matter structuresRight caudate nucleusCo-morbid anxietyLeft caudate nucleusObsessive-compulsive disorder patientsSubcortical brain morphologyGray matter structuresDisease durationMedication useObsessive-compulsive disorderSubgroup analysisBrain MRINucleus accumbensDisorder patientsPatientsBrain volumePutamenCellular and Molecular Pathology in Tourette Syndrome
Fasching L, Brady M, Vaccarino F. Cellular and Molecular Pathology in Tourette Syndrome. 2022, 171-183. DOI: 10.1093/med/9780197543214.003.0012.ChaptersTourette syndromeBasal gangliaAminobutyric acid-ergic interneuronsActive cholinergic interneuronsPathophysiology of TSCholinergic interneuronsPathological findingsMicroglial cellsTic disordersCaudate nucleusCortical hemispherePathogenic mechanismsInterneuronsSyndromeMolecular pathologyGangliaProminent increaseAvailable literatureInflammationPathophysiologyPutamenFindingsPathology
2020
Apathy in Alzheimer’s Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei
Udo N, Hashimoto N, Toyonaga T, Isoyama T, Oyanagi Y, Narita H, Shiga T, Nakagawa S, Kusumi I. Apathy in Alzheimer’s Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei. Dementia And Geriatric Cognitive Disorders Extra 2020, 10: 86-93. PMID: 33082772, PMCID: PMC7548940, DOI: 10.1159/000509278.Peer-Reviewed Original ResearchSignificant inverse correlationAlzheimer's diseaseCaudate nucleusParkinson's diseaseDisease correlateBP valuesI-FP-CIT single-photon emissionJ scoresAlzheimer's Disease CorrelatesInverse correlationDopamine transporter levelsCommon neuropsychiatric symptomsI-FP-CITTypes of dementiaDopaminergic nervous systemRight caudate nucleusDevelopment of apathyRank correlation coefficientStriatal binding potentialLeft caudate nucleusDegree of apathySingle photon emissionOvert parkinsonismNeuropsychiatric symptomsLewy bodies
2019
Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder
Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E, Shavitt R, Hoexter M, Batistuzzo M. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder. European Child & Adolescent Psychiatry 2019, 28: 1607-1617. PMID: 30972581, DOI: 10.1007/s00787-019-01320-w.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGroup cognitive behavioral therapyPediatric obsessive-compulsive disorderRight caudateTreatment responseCognitive behavioral therapyCaudate nucleusPossible neural substrateTreatment respondersGM volumeStructural magnetic resonance imagingNeural substratesPrevious evidenceNeurobiological underpinningsOrbitofrontal cortexAge-matched controlsTotal GM volumeMagnetic resonance imagingBrain structuresResonance imagingChildrenRespondersBonferroni correctionCaudatePatientsImaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain
Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.Peer-Reviewed Original ResearchConceptsTest-retest variabilityNondisplaceable distribution volumeOccipital cortexEnzyme 11β-hydroxysteroid dehydrogenase type 1White matterDistribution volumeTreatment of depressionDehydrogenase type 1Large cortical regionsPosttraumatic stress disorderHuman brainAdditional scansIntraclass correlation coefficientAge-related cognitive functionBolus administrationFrontal cortexCaudate nucleusAdipose tissueTime-activity curvesNovel radiotracersGlucocorticoid levelsParietal cortexCortical regionsPattern of uptakeType 1SU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS
Lisboa B, Tahira A, Sant'Anna A, Oliveira K, Miguel E, Hoexter M, Farfel J, Brentani H. SU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS. European Neuropsychopharmacology 2019, 29: s927. DOI: 10.1016/j.euroneuro.2017.08.261.Peer-Reviewed Original ResearchObsessive-compulsive disorderNucleus accumbensSubgenual cingulate gyrusCortico-striatal circuitryOrbitofrontal cortexAffective circuitryCingulate gyrusCaudate nucleusBrain areasCognitive circuitryBrazilian Aging Brain Study GroupCompulsive disorderEnsheathment of neuronsEnrichment analysisBackground Obsessive-compulsive disorderDrug metabolic processFunctional neuroimaging studiesCortico-striatal loopsDopaminergic synapsesBrain BankThalamic circuitryGene expressionStudy groupNeurological system processPsychiatric disorders
2018
Structural correlates of cognitive impairment in normal pressure hydrocephalus
Peterson KA, Mole TB, Keong NCH, DeVito EE, Savulich G, Pickard JD, Sahakian BJ. Structural correlates of cognitive impairment in normal pressure hydrocephalus. Acta Neurologica Scandinavica 2018, 139: 305-312. PMID: 30428124, PMCID: PMC6492129, DOI: 10.1111/ane.13052.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusNPH patientsNeuropsychiatric symptomsPressure hydrocephalusNeuropsychiatric measuresNeuropsychological testsStructure volumesStriatal volume lossDeep gray matter structuresMeasures of apathySubcortical deep gray matter structuresT1-weighted magnetic resonanceGray matter structuresNAcc volumeSmaller caudateNeuropsychiatric changesHealthy controlsPathological basisNPH groupCaudate nucleusNucleus accumbensCaudate volumePatientsSubcortical regionsCognitive impairment
2017
Functional Connectivity Parcellation of the Human Thalamus by Independent Component Analysis
Zhang S, Li CR. Functional Connectivity Parcellation of the Human Thalamus by Independent Component Analysis. Brain Connectivity 2017, 7: 602-616. PMID: 28954523, PMCID: PMC5695755, DOI: 10.1089/brain.2017.0500.Peer-Reviewed Original ResearchConceptsWhole-brain connectivityThalamic connectivityFunctional connectivityState functional magnetic resonanceTime coursePrimary motor cortexWhole-brain functional connectivitySeed region analysisBrain functional connectivityFunctional magnetic resonanceIndependent component time coursesMotor cortexThalamic subdivisionsHuman thalamusCaudate nucleusThalamic clustersThalamusSubcortical regionsBrain regionsRegional functionPatterns of connectivityAffective functionsFunctional organizationMagnetic resonanceFunctional clusters
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic stateInteraction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 2016, 59: 2622-2631. PMID: 27600277, DOI: 10.1007/s00125-016-4095-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdministration, IntranasalAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulinInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiddle AgedObesityPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsInsulin sensitivityReceptor densityCaudate nucleusDopamine D2 receptor densityFTO obesity-risk alleleANKK1 polymorphismCentral insulin sensitivityIntranasal insulin administrationPeripheral insulin sensitivityBrain insulin sensitivityRisk of obesityDopamine receptor densityD2 receptor availabilityObesity risk allelesD2 receptor densityTübingen Family studyMalmö DietWaist circumferenceFTO SNP rs8050136FTO variationInsulin administrationD2 receptorsFood intakeBody fatBody composition
2013
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher Body Mass IndexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociation
2012
Differential effects of age on human striatal adenosine A1 and A2A receptors
Mishina M, Kimura Y, Naganawa M, Ishii K, Oda K, Sakata M, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K. Differential effects of age on human striatal adenosine A1 and A2A receptors. Synapse 2012, 66: 832-839. PMID: 22623181, DOI: 10.1002/syn.21573.Peer-Reviewed Original ResearchConceptsDistribution volume ratioEffect of ageCaudate nucleusPET scanningAge-related decreaseElderly subjectsElderly volunteersAdenosine A1Healthy subjectsPET scansA2A receptorsYoung subjectsHuman striatumStriatumReceptorsAgePutamenDifferential effectsPrevious reportsSubjectsAdenosineDistribution of adenosinePropylxanthineHead
2011
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K. Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients. PLOS ONE 2011, 6: e17338. PMID: 21386999, PMCID: PMC3046146, DOI: 10.1371/journal.pone.0017338.Peer-Reviewed Original ResearchConceptsDrug-naïve patientsDrug-naïve PD patientsPositron emission tomographyPD patientsParkinson's diseaseAntiparkinsonian therapyControl subjectsAffected sideDisease patientsCaudate nucleusParkinson's disease patientsElderly control subjectsNormal control subjectsSelective A2AR antagonistAdenosine A2A receptorsDistribution volume ratioMild dyskinesiaA2AR antagonistDopaminergic systemBilateral putamenPET scansPatientsA2A receptorsNovel treatmentsPutamenSex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI
Skup M, Zhu H, Wang Y, Giovanello KS, Lin JA, Shen D, Shi F, Gao W, Lin W, Fan Y, Zhang H, Initiative T. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI. NeuroImage 2011, 56: 890-906. PMID: 21356315, PMCID: PMC3085726, DOI: 10.1016/j.neuroimage.2011.02.060.Peer-Reviewed Original ResearchConceptsGrey matter atrophy patternsAlzheimer's Disease Neuroimaging InitiativeProbable Alzheimer's diseaseAlzheimer's diseaseAmnestic mild cognitive impairmentAtrophy patternsDisease Neuroimaging InitiativeLongitudinal magnetic resonance imaging (MRI) dataPredetermined brain regionsBilateral caudate nucleusAMCI groupBilateral middle temporal gyrusVoxel-wise analysisMild cognitive impairmentGray matter regionsMiddle temporal gyrusBilateral thalamusBrain atrophyStructural MRI dataHealthy controlsGrey matter dataMagnetic resonance imaging dataAD groupBilateral precuneusCaudate nucleus
2009
Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE. Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain. Molecular Therapy 2009, 18: 588-593. PMID: 20010918, PMCID: PMC2839442, DOI: 10.1038/mt.2009.286.Peer-Reviewed Original ResearchConceptsSubstantia nigraPrimate brainCaudate nucleusSerotype 1Central nervous systemProtein-positive cellsAAV serotype 2Long-term transductionNigrostriatal systemClinical trialsPositive cellsNervous systemUnbiased stereologyVector injectionComparable titersNeural cellsBrainTransduction efficiencySerotype 2Vector transduction efficiencyTherapeutic transgenesViral vectorsNigraEnhanced green fluorescent protein (EGFP) reporter geneAAV vectorsDeficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia Nervosa
Marsh R, Steinglass J, Gerber A, O’Leary K, Wang Z, Murphy D, Walsh B, Peterson B. Deficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia Nervosa. JAMA Psychiatry 2009, 66: 51-63. PMID: 19124688, PMCID: PMC2759684, DOI: 10.1001/archgenpsychiatry.2008.504.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBulimia NervosaCaudate NucleusCorpus StriatumDiscrimination, PsychologicalDominance, CerebralFemaleFrontal LobeGyrus CinguliHumansImage Processing, Computer-AssistedImpulsive BehaviorInternal-External ControlMagnetic Resonance ImagingNerve NetOrientationOxygenPattern Recognition, VisualPrefrontal CortexPsychomotor PerformanceReference ValuesConceptsAnterior cingulate cortexBulimia nervosaHealthy controlsCingulate cortexFrontostriatal circuitsMain outcome measuresBlood oxygenation level-dependent (BOLD) responseDorsal anterior cingulate cortexAnterior cingulate cortex activityHealthy control participantsSimon Spatial Incompatibility taskTask-related activationCingulate cortex activityLevel-dependent responsesBilateral inferior frontal gyrusFunctional magnetic resonanceSelf-regulatory controlNeural systemsGeneral linear modelingInferior frontal gyrusFunctional abnormalitiesOutcome measuresCaudate nucleusSevere symptomsPatients
2008
The dynamics of deductive reasoning: An fMRI investigation
Rodriguez-Moreno D, Hirsch J. The dynamics of deductive reasoning: An fMRI investigation. Neuropsychologia 2008, 47: 949-961. PMID: 18835284, DOI: 10.1016/j.neuropsychologia.2008.08.030.Peer-Reviewed Original ResearchConceptsDeductive reasoningReasoning processParietal regionsEvent-related fMRISupramodal networkPrevious imaging studiesNeural correlatesFMRI investigationOccipital complexLanguage areasBilateral caudate nucleusInformation processingReasoningSecond premiseImaging studiesTraditional focusCaudate nucleusSubstantive differencesFMRISubsequent conclusionsTime courseScientific investigationPhilosophical discussionCorrelatesTime points
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