2025
Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions. Journal Of Clinical Sleep Medicine 2025, 21: 1165-1173. PMID: 40110600, PMCID: PMC12225272, DOI: 10.5664/jcsm.11630.Peer-Reviewed Original ResearchRapid eye movementSlow wave sleepSleep architectureArousal indexAssociated with smaller volumesCerebral microbleedsLobar cerebral microbleedsProportion of rapid eye movementBaseline sleep architectureRapid eye movement sleepProportion of slow wave sleepAssociated with cerebral microbleedsEye movement sleepSleep architecture variablesModifiable risk factorsAtrophy of hippocampusSleep deficiencyMedian ageParietal regionsMovement sleepMRI outcomesAssociated with brain atrophyAnatomical featuresRisk factorsCuneus regions
2024
Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e093827. PMCID: PMC11713325, DOI: 10.1002/alz.093827.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleepLower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions
Cho G, Mecca A, Buxton O, Liu X, Miner B. Lower slow wave sleep and rapid eye‐movement sleep are associated with brain atrophy of AD‐vulnerable regions. Alzheimer's & Dementia 2024, 20: e089369. PMCID: PMC11716384, DOI: 10.1002/alz.089369.Peer-Reviewed Original ResearchInferior parietal regionsSlow wave sleepAD-vulnerable regionsAssociated with smaller volumesParietal regionsPresence of cerebral microbleedsSleep architectureAlzheimer's diseaseCerebral microbleedsIncreased risk of Alzheimer's diseaseProportion of timeRisk of Alzheimer's diseaseBaseline cognitive functionLobar cerebral microbleedsModifiable risk factorsAssociated with lower volumesAssociated with brain atrophyBaseline sleep architectureSleep architecture variablesSleep deficiencyAssociated with ADFalse discovery rateAtherosclerosis RiskAD pathogenesisEye-movement sleep
2020
Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes
West R, Livny A, Ravona-Springer R, Bendlin B, Heymann A, Leroith D, Liu X, Lin H, Hochner H, Friedlander Y, Ganmore I, Tirosh A, Schnaider Beeri M. Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes. Diabetologia 2020, 63: 2446-2451. PMID: 32862254, PMCID: PMC7530092, DOI: 10.1007/s00125-020-05264-8.Peer-Reviewed Original ResearchConceptsAssociation of adiposityInferior frontal gyrusType 2 diabetesRegional brain volumesOlder adultsFrontal gyrusSample of older individualsTrajectories of BMICognitive Decline studyLong-term trajectoriesAssociation of BMIBMI trajectory groupsTrajectory of obesityLong-term adiposityBrain volumeAssociated with smaller regional brain volumesInferior frontal gyrus volumeRelevant to cognitive functionTotal gray matter volumeDementia riskAssociated with smaller volumesMiddle frontal gyrusMiddle temporal gyrusSuperior frontal gyrusGray matter volume
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