2025
Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood
Duda J, Keding T, Kribakaran S, Odriozola P, Kitt E, Cohodes E, Zacharek S, McCauley S, Haberman J, Joormann J, Gee D. Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood. Developmental Cognitive Neuroscience 2025, 74: 101578. PMID: 40493990, PMCID: PMC12179744, DOI: 10.1016/j.dcn.2025.101578.Peer-Reviewed Original ResearchUnpredictable childhood environmentsChildhood unpredictabilityExtinction learningAmygdala activationChildhood environmentAssociated with amygdala activationBasolateral amygdala activityChildhood trauma exposureSkin conductance responsesCross-species researchThreat cuesTrauma exposureNeural regionsSafety learningEarly adversityHealthy young adultsCurrent anxietyAssociated with activationConductance responsesCaregiving environmentAffective functioningHealthy neurodevelopmentNeural activityTargeted clinical interventionsIn adulthoodFocusing attention in working and long-term memory through dissociable mechanisms
Gong D, Draschkow D, Nobre A. Focusing attention in working and long-term memory through dissociable mechanisms. Nature Communications 2025, 16: 4126. PMID: 40319062, PMCID: PMC12049562, DOI: 10.1038/s41467-025-59359-0.Peer-Reviewed Original ResearchConceptsLong-term memoryWorking memoryPerceptual tasksLTM representationsSpatial working memoryMemory typesSensory information processingAttentional orientingAttentional prioritizationMemory itemsHealthy young adultsGaze biasAttentional cuesVisual discriminationVisual stimuliItem matchingEye trackingInformation processingBenefit performanceYoung adultsMemoryGaze shiftsNon-spatialTaskItemsPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structures
2024
Human brain state dynamics are highly reproducible and associated with neural and behavioral features
Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human brain state dynamics are highly reproducible and associated with neural and behavioral features. PLOS Biology 2024, 22: e3002808. PMID: 39316635, PMCID: PMC11421804, DOI: 10.1371/journal.pbio.3002808.Peer-Reviewed Original ResearchConceptsCo-activation patternsResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehavioral featuresNeural variationsMoment-to-moment changesSingle-subject levelBrain state dynamicsEmotion regulationHealthy young adultsBehavioral phenotypesCognitive functionSubstance useNeural activityNeuroimaging markersNeural featuresYoung adultsMagnetic resonance imagingCo-activationResonance imagingCo-variationNeuroimagingIndividualsEmotionsFunctional outcomesDoes a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?
Fernandes I, Stavres J, Hamaoka T, Ojikutu Q, Sabino-Carvalho J, Vianna L, Luck J, Blaha C, Cauffman A, Dalton P, Herr M, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults? Journal Of Neurophysiology 2024, 132: 922-928. PMID: 39110514, PMCID: PMC12121373, DOI: 10.1152/jn.00264.2024.Peer-Reviewed Original ResearchAdministration of amilorideArterial baroreflex sensitivityCardiac autonomic modulationBaroreflex sensitivityOral administrationBP variabilityBlood pressureOral administration of placeboAutonomic modulationSpontaneous cardiac baroreflexSympathetic arterial baroreflexAdministration of placeboIndices of BP variabilityMuscle sympathetic activitySympathetic baroreflex sensitivityHealthy young adultsPre-clinical modelsSingle oral administrationBlood pressure variabilityBeat-to-beat BPYoung adultsWeighted linear regression analysisHealthy young humansSympathetic baroreflexAmilorideEntropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping – A Preliminary Report
Rao N, Paek A, Contreras-Vidal J, Parikh P. Entropy in Electroencephalographic Signals Modulates with Force Magnitude During Grasping – A Preliminary Report. Journal Of Motor Behavior 2024, 56: 665-677. PMID: 39056321, PMCID: PMC11449659, DOI: 10.1080/00222895.2024.2373241.Peer-Reviewed Original ResearchMaximum voluntary contractionGrip force controlIsometric force control tasksHealthy young adultsNeural processesGrip forceGrip force magnitudeParietal electrodesParietal regionsContralateral hemisphereWithin-trialNeural variabilityEEG variablesControl taskForce control taskNeural entropyStudy investigated roleYoung adultsForce magnitudeVoluntary contractionElectroencephalography activityCentral electrodeElectroencephalographyNoninvasive electroencephalographyTrials
2023
1271-P: Associations of Combined Socioeconomic, Behavioral, and Metabolic Factors with Undiagnosed Diabetes and Prediabetes among Different Racial and Ethnic Groups
DING Q, LU Y, HERRIN J, ZHANG T, MARRERO D. 1271-P: Associations of Combined Socioeconomic, Behavioral, and Metabolic Factors with Undiagnosed Diabetes and Prediabetes among Different Racial and Ethnic Groups. Diabetes 2023, 72 DOI: 10.2337/db23-1271-p.Peer-Reviewed Original ResearchUndiagnosed diabetesRace/ethnicityMetabolic factorsPrediabetes riskHealthcare accessNutrition Examination SurveyShort sleep durationPoor diet qualityNon-Hispanic blacksHealthy young adultsNon-Hispanic whitesExamination SurveyDiabetes riskChronic conditionsNational HealthAlcohol consumersPrediabetesHigh riskSleep durationDiabetesCluster 3Old maleDiet qualityLogistic regressionYoung adultsStructural and functional asymmetry of the neonatal cerebral cortex
Williams L, Fitzgibbon S, Bozek J, Winkler A, Dimitrova R, Poppe T, Schuh A, Makropoulos A, Cupitt J, O’Muircheartaigh J, Duff E, Cordero-Grande L, Price A, Hajnal J, Rueckert D, Smith S, Edwards A, Robinson E. Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour 2023, 7: 942-955. PMID: 36928781, DOI: 10.1038/s41562-023-01542-8.Peer-Reviewed Original ResearchConceptsCortical asymmetryHealthy term-born neonatesNeonatal cerebral cortexTerm-born neonatesTerm-equivalent ageHealthy young adultsHuman Connectome ProjectPreterm birthPreterm neonatesNeonatal cortexCerebral cortexTerm cohortFunctional magnetic resonance imagesMagnetic resonance imagesConnectome ProjectBrain asymmetryYoung adultsSignificant differencesNeonatesResonance imagesFunctional asymmetryCortexBirthBiological sexCohort
2022
Systems of Care for Transitional-Age Youth With Severe Mental Illness
Wilson C, Parke S, VanDeusen T, Millard H, Qayyum Z, Kim H. Systems of Care for Transitional-Age Youth With Severe Mental Illness. Psychiatric Annals 2022, 52: 238-242. DOI: 10.3928/00485713-20220527-01.Peer-Reviewed Original ResearchTransitional age youthSevere mental illnessSystems of careMental illnessDevelopmental periodUnique psychosocial needsHealthy young adultsMental health systemInformed treatment planningBest possible outcomeCare needsPsychosocial needsMental healthSubstance abuseBrain developmentHealth systemDevelopmental entityYoung adultsAge 15YouthTreatment planningIllnessCarePossible outcomesCommon goal
2021
Comparing cognition, coping skills and vedic personality of individuals practicing yoga, physical exercise or sedentary lifestyle: a cross-sectional fMRI study
Kaur H, Chaudhary S, Mohanty S, Sharma G, Kumaran S, Ghati N, Bhatia R, Nehra A, Pandey R. Comparing cognition, coping skills and vedic personality of individuals practicing yoga, physical exercise or sedentary lifestyle: a cross-sectional fMRI study. Integrative Medicine Research 2021, 11: 100750. PMID: 34194974, PMCID: PMC8237306, DOI: 10.1016/j.imr.2021.100750.Peer-Reviewed Original ResearchPhysical activity groupActivity groupPhysical activityYoga practitionersCross-sectional fMRI studyVedic Personality InventoryCross-sectional studyLifestyle groupHealthy young adultsVerbal n-backSuperior frontal gyrusBrief COPE scaleTesla MRI scannerYoga groupSedentary lifestyleCONN toolboxBrain areasPhysical exerciseStroop taskCognitive domainsFMRI studyFrontal gyrusInhibitory controlYoung adultsCOPE scale
2020
Acute Hepatic Failure
Ghosh S, Bassily‐Marcus A. Acute Hepatic Failure. 2020, 359-364. DOI: 10.1002/9781119293255.ch39.Peer-Reviewed Original ResearchCause of acute hepatic failureAcute hepatic failureHepatic failurePredictor of liver transplantationPre-existing liver diseaseDegree of hepatic encephalopathyDrug-induced hepatitisTime of presentationNational society guidelinesTreatment of acute hepatic failureLife-threatening critical illnessLiver transplantationViral hepatitisAcetaminophen toxicitySociety guidelinesHepatic encephalopathyLiver diseaseCritical illnessMortality rateHealthy young adultsHepatitisYoung adultsPrimary causePrognosisTransplantationTime-course of pain threshold after continuous theta burst stimulation of primary somatosensory cortex in pain-free subjects
Rao N, Chen Y, Ramirez R, Tran J, Li S, Parikh P. Time-course of pain threshold after continuous theta burst stimulation of primary somatosensory cortex in pain-free subjects. Neuroscience Letters 2020, 722: 134760. PMID: 31996315, DOI: 10.1016/j.neulet.2020.134760.Peer-Reviewed Original ResearchConceptsElectrical pain thresholdPain thresholdPain processingPrimary somatosensory cortexTheta burst stimulationElevated pain thresholdSomatosensory cortexCorticospinal excitabilityPain management strategiesBurst stimulationContinuous theta burst stimulationTime courseNeuropathic painYoung adultsMeasures of M1 excitabilityPainSham stimulationExcitability of primary motor cortexReduced corticospinal excitabilityHealthy young adultsEffects of continuous theta burst stimulationShamStimulationPrimary motor cortexM1 excitability
2019
Fronto-Parietal Brain Areas Contribute to the Online Control of Posture during a Continuous Balance Task
Goel R, Nakagome S, Rao N, Paloski W, Contreras-Vidal J, Parikh P. Fronto-Parietal Brain Areas Contribute to the Online Control of Posture during a Continuous Balance Task. Neuroscience 2019, 413: 135-153. PMID: 31200107, DOI: 10.1016/j.neuroscience.2019.05.063.Peer-Reviewed Original ResearchConceptsBalance tasksContinuous balance taskHealthy young adultsPostural controlTranscranial magnetic stimulationPostural control mechanismsContinuous theta burst stimulationFronto-parietal brain areasControl of postureSham stimulationYoung adultsPostural tasksAnterior cingulatePostural responsesCingulate gyrusBrain areasSway referenceSensory conditionsPostural behaviorDisruptive transcranial magnetic stimulationBilateral posterior parietal regionsFronto-parietal regionsMagnetic stimulationPosterior parietal regionsTheta burst stimulationThe Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson L, Colbourne L, Smith A, Harmer C, Nobre A, Rendell J, Jones H, Hinds C, Mould A, Tunbridge E, Cipriani A, Geddes J, Saunders K, Harrison P. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials 2019, 20: 120. PMID: 30755265, PMCID: PMC6373140, DOI: 10.1186/s13063-019-3175-0.Peer-Reviewed Original ResearchConceptsMood instabilityExperimental medicine studiesPsychiatric disordersPlacebo-controlled experimental medicine studyL-type calcium channelsAetiology of psychiatric disordersCalcium channel antagonismBipolar disorderHealthy young adultsMoodCognitionCalcium channel geneVoltage-gated calcium channel geneYoung adultsDouble-blindMedicine studiesDisordersAntagonist nicardipineCalcium channelsSleepCACNA1CChannel genesTreat hypertensionOxford studyTherapeutic potential
2017
Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults
Shen J, Qin W, Xu Q, Xu L, Xu J, Zhang P, Liu H, Liu B, Jiang T, Yu C. Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults. Brain Structure And Function 2017, 222: 2877-2889. PMID: 28229235, PMCID: PMC5541082, DOI: 10.1007/s00429-017-1377-3.Peer-Reviewed Original ResearchConceptsHippocampal resting-state functional connectivityResting-state functional connectivityNegative rsFCNon-E4 carriersCingulate cortexAssociated with Alzheimer's diseaseHealthy young adultsFunctional connectivityPositive resting-state functional connectivityG allele carriersEffect of apolipoprotein ESubgenual anterior cingulate cortexRisk G-allele carriersInferior frontal gyrusAnterior cingulate cortexMiddle temporal gyrusPrecuneus/posterior cingulate cortexHippocampal functional connectivityNo significant additive interactionAPOE interactionsYoung adultsApolipoprotein EFrontal gyrusHippocampal impairmentTemporal gyrus
2016
APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults
Zhang N, Liu H, Qin W, Liu B, Jiang T, Yu C. APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults. Cerebral Cortex 2016, 27: 4797-4805. PMID: 27620974, DOI: 10.1093/cercor/bhw276.Peer-Reviewed Original ResearchConceptsFunctional connectivity densityDorsolateral prefrontal cortexBrain functional connectivityHealthy young adultsFunctional connectivityYoung adultsRight middle temporal gyrusDecreased FCDIncreased FCDBrain functional connectivity densityBilateral middle occipital gyriMiddle temporal gyrusMiddle occipital gyriLeft parahippocampal gyrusInfluence long-term potentiationGenetic variations of APOELong-term potentiationPrefrontal cortexEpistatic interactionsTemporal gyrusParahippocampal gyrusOccipital gyriBrain regionsModulating glutamate receptorsBrain connectivityThe effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
Manza P, Hu S, Ide JS, Farr OM, Zhang S, Leung HC, Li CR. The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task. Journal Of Psychopharmacology 2016, 30: 283-293. PMID: 26755547, PMCID: PMC4837899, DOI: 10.1177/0269881115625102.Peer-Reviewed Original ResearchConceptsUnsigned prediction errorsStop-signal taskConflict anticipationVentromedial prefrontal cortexEffects of methylphenidateDorsal anterior cingulateInferior parietal lobulePresupplementary motor areaCognitive controlHealthy young adultsNeural processesUpcoming conflictTask performanceNeural mechanismsBilateral caudate headParietal lobulePrediction errorPrefrontal cortexAnterior cingulateAdaptive behaviorParahippocampal gyrusMethylphenidateMotor areaAnticipation activityYoung adults
2015
Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults
Shen J, Zhang P, Liu H, Xu L, Xu J, Qin W, Liu B, Jiang T, Yu C. Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults. Brain Structure And Function 2015, 221: 4103-4110. PMID: 26627482, DOI: 10.1007/s00429-015-1149-x.Peer-Reviewed Original ResearchConceptsLate-onset Alzheimer's diseaseAssociated with late-onset Alzheimer's diseaseHealthy young adultsFunctional connectivity densitySortilin-related receptor 1 geneYoung adultsSusceptibility to late-onset Alzheimer's diseaseChinese Han subjectsG allele carriersRisk allele carriersChinese Han populationSortilin-related receptor 1Right inferior temporal gyrusRisk G-allele carriersTT carriersMRI examinationsInvestigate associationsSingle-nucleotide polymorphismsAllele carriersRisk subjectsReceptor 1Han subjectsHan populationBrain functional propertiesConnectivity densityMotor learning and modulation of prefrontal cortex: an fNIRS assessment
Ono Y, Noah JA, Zhang X, Nomoto Y, Suzuki T, Shimada S, Tachibana A, Bronner S, Hirsch J. Motor learning and modulation of prefrontal cortex: an fNIRS assessment. Journal Of Neural Engineering 2015, 12: 066004. PMID: 26401727, DOI: 10.1088/1741-2560/12/6/066004.Peer-Reviewed Original ResearchConceptsDance video gameHemodynamic responsePrefrontal cortexMotor tasksMotor learningMotor performanceSpecific rehabilitation programPrefrontal hemodynamic responsesBaseline patternsHealthy young adultsTraining-induced changesComplex motor tasksRehabilitation programYoung adultsRegression analysisCortexRegression modelsAuditory cuesNovice playersSensitive indicatorResponseParticipants
2014
Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling
Lee N, Shin MS, Kang KS, Yoo SA, Mohanty S, Montgomery RR, Shaw AC, Kang I. Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. Clinical Immunology 2014, 152: 101-110. PMID: 24657713, PMCID: PMC4018768, DOI: 10.1016/j.clim.2014.03.003.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply