2025
Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development
Bjertrup A, Andreu H, Macoveanu J, Sankar A, Moszkowicz M, Nielsen R, Pagsberg A, Vieta E, Kessing L, Miskowiak K. Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development. Psychiatry Research 2025, 351: 116610. PMID: 40582275, DOI: 10.1016/j.psychres.2025.116610.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingMother-infant interactionBipolar disorderMother infant interactionsFearful facesNeural responsesInfant interactionsNeural activityInfant developmentEmotion processing regionsHappy facial expressionsWhole-brain analysisSevere mood disordersLeft frontal poleFacial expression recognition taskFacial expression recognition accuracyExpression recognition taskHappy facesPrefrontal responsesBD mothersMood disordersChildren of individualsFrontal poleDyadic reciprocityProcessing regionsA large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing
Klöbl M, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Gryglewski G, Nics L, Hahn A, Rujescu D, Hacker M, Lanzenberger R. A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing. Translational Psychiatry 2025, 15: 196. PMID: 40500269, PMCID: PMC12159172, DOI: 10.1038/s41398-025-03407-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortex activationAnterior cingulate cortexMajor depressive disorderFunctional magnetic resonance imagingSerotonin transporter availabilitySerotonin transporterEmotional processingSerotonergic systemDiagnosis of major depressive disorderAnxiolytic effect of citalopramFacial emotion processing taskMonths of antidepressant treatmentViewing fearful facesAcute anxiolytic effectsEmotion processing taskEffect of citalopramReduced fMRI activationSuperior frontal sulcusSERT availabilityFearful facesHappy facesAntidepressant treatmentFear processingNeutral facesDepressive disorder
2024
The influence of psilocybin on subconscious and conscious emotional learning
Casanova A, Ort A, Smallridge J, Preller K, Seifritz E, Vollenweider F. The influence of psilocybin on subconscious and conscious emotional learning. IScience 2024, 27: 110034. PMID: 38883812, PMCID: PMC11177198, DOI: 10.1016/j.isci.2024.110034.Peer-Reviewed Original ResearchPsychedelic-Assisted PsychotherapyAgonist psilocybinFearful facesNeutral cuesEmotional cuesPsychiatric disordersSerotonergic psychedelicsSerotonin SignalingExploratory behaviorPsilocybinEmotional learningLearning effectCuesPlacebo groupPlaceboPsychotherapyLearning rateLearningPsychedelicsSerotoninReinforcement learningDisordersTreatment modalitiesBrainTaskNeural differentiation of emotional faces as a function of interpersonal violence among adolescent girls
Tamman A, Abdallah C, Dunsmoor J, Cisler J. Neural differentiation of emotional faces as a function of interpersonal violence among adolescent girls. Journal Of Psychiatric Research 2024, 172: 90-101. PMID: 38368703, DOI: 10.1016/j.jpsychires.2024.02.015.Peer-Reviewed Original ResearchRepresentational similarity analysisInterpersonal violenceUnivariate activityNeutral facesFacial emotion processing taskEffects of trauma typeEmotion processing taskMultivoxel activity patternsMechanisms of riskFearful facesEmotional facesThreat processingFacial stimuliAbuse severityNeural alterationsPsychiatric diagnosisPsychiatric disordersTrauma typesPsychiatric medicationsRight hippocampusAssault severityNeural patternsPhysical assaultPhysical abuseUnique contributionsLess attention to emotional faces is associated with low empathy and prosociality in 12‐to 20‐month old infants
Donohue M, Camacho M, Drake J, Schwarzlose R, Brady R, Hoyniak C, Hennefield L, Wakschlag L, Rogers C, Barch D, Luby J. Less attention to emotional faces is associated with low empathy and prosociality in 12‐to 20‐month old infants. Infancy 2024, 29: 113-136. PMID: 38173191, PMCID: PMC10872599, DOI: 10.1111/infa.12569.Peer-Reviewed Original ResearchConceptsNegative emotional facesEmotional facesDevelopment of empathyEye regionAssociated with less empathyEye region of facesAssociated with lower empathyEmotional processing skillsRegion of facesAngry facesFearful facesEmotional processingInfant attentionLow empathyAssociated with disruptionProsocial behaviorDecreased attentionProsocial helpingDiverse sampleComfort behaviourDevelopmental periodEffect sizeProsocialityProcess skillsEmpathyPre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differencesAmygdala response to emotional faces following acute administration of psilocybin in healthy individuals
Armand S, Larsen K, Madsen M, Ozenne B, Preller K, Knudsen G, Stenbæk D, Fisher P. Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals. Neuroscience Applied 2024, 3: 103934. DOI: 10.1016/j.nsa.2023.103934.Peer-Reviewed Original ResearchPlasma psilocin levelsFunctional magnetic resonance imagingAmygdala reactivityHealthy individualsAmygdala responseMagnetic resonance imagingAcute administrationDrug intensityAcute exposureTherapeutic outcomesResonance imagingSignificant associationBrain regionsPsychedelic psilocybinPsilocybinBaselineFuture studiesSignificant changesExposureFearful facesEmotion processingResponseIndividualsAdministration
2023
Attentional biases in facial emotion processing in individuals at clinical high risk for psychosis
Williams T, Cohen A, Sanchez-Lopez A, Joormann J, Mittal V. Attentional biases in facial emotion processing in individuals at clinical high risk for psychosis. European Archives Of Psychiatry And Clinical Neuroscience 2023, 273: 1825-1835. PMID: 36920535, PMCID: PMC10502185, DOI: 10.1007/s00406-023-01582-1.Peer-Reviewed Original ResearchConceptsFacial emotion processingEye-tracking paradigmAttentional biasesClinical high riskSocial functioningEmotion processingNegative symptomsCHR individualsAttentional bias indicesGlobal social functioningPoor social functioningFearful facesHappy facesNeutral facesPsychosis exhibitCHR groupSuch biasesBias indexComorbid disordersClinical InterviewFunctioningPrevious researchBiasesCHR syndromeDepressive symptomsThe Role of Family-Level Factors in Childhood Anxiety During the COVID-19 Pandemic
Kitt E, Cohodes E, McCauley S, Hommel G, Nardini C, Zacharek S, Martino A, Anderson T, Spencer H, Odriozola P, Spurrier G, Broussard A, Marin C, Silverman W, Lebowitz E, Gee D. The Role of Family-Level Factors in Childhood Anxiety During the COVID-19 Pandemic. Journal Of Emotion And Psychopathology 2023, 1: 129-151. DOI: 10.55913/joep.v1i1.18.Peer-Reviewed Original ResearchCOVID-19-related fearCOVID-19-related stressFamily-level factorsAmygdala reactivityAnxiety disordersChildren's useEmotion regulation strategiesParent-child dynamicsExpressive suppressionAnxious youthFearful facesChildhood anxietyFMRI taskPediatric anxietyRegulation strategiesOwn functioningCOVID-19 pandemicFamily exposureMultimodal studyFearPervasive disruptionChildren's exposureFamily lifeParental assistanceAnxiety
2022
Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2019
Changing Interpretations of Emotional Expressions in Working Memory With Aging
Mok R, van der Meulen J, Holmes E, Nobre A. Changing Interpretations of Emotional Expressions in Working Memory With Aging. Emotion 2019, 19: 1060-1069. PMID: 30321038, PMCID: PMC6764502, DOI: 10.1037/emo0000481.Peer-Reviewed Original ResearchConceptsWorking memoryYoung adultsInterpretation of emotional expressionsEmotion-laden stimuliAge-related impairmentFearful facesEmotional materialWM performanceWM accuracyEmotional biasExperimental tasksEmotional expressionPositive biasAffective representationsFacial expressionsOlder adultsFuture behaviorMemoryAdultsTaskBiasImpairmentStimuliPositive effectAgeOxytocin Enhances the Neural Efficiency of Social Perception
Tillman R, Gordon I, Naples A, Rolison M, Leckman JF, Feldman R, Pelphrey KA, McPartland JC. Oxytocin Enhances the Neural Efficiency of Social Perception. Frontiers In Human Neuroscience 2019, 13: 71. PMID: 30914935, PMCID: PMC6421852, DOI: 10.3389/fnhum.2019.00071.Peer-Reviewed Original ResearchEmotional facesFace perceptionN170 latencyNeutral facesSocial perceptionExperiment 1Experiment 2Face processing taskNeutral facial expressionsSpecialized neural circuitryEffects of oxytocinDifferent facial featuresFearful facesNeural efficiencyEmotional expressionNeural correlatesInformative cuesIndividual differencesNeural processesParticipants' gazeNeural substratesFacial expressionsSubjects designNeural circuitryOT influencesReduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects
2012
RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder.
Wegbreit E, Passarotti AM, Ellis JA, Wu M, Witowski N, Fitzgerald JM, Stevens MC, Pavuluri MN. RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder. Journal Of Affective Disorders 2012, 147: 304-311. PMID: 23261134, PMCID: PMC3606663, DOI: 10.1016/j.jad.2012.11.025.Peer-Reviewed Original ResearchConceptsFearful facesPrefrontal cortexNeutral facesRight dorsolateral prefrontal cortexEmotion-attention interactionsEnhanced neural processingVentrolateral prefrontal cortexEmotional processing regionsDorsolateral prefrontal cortexAdolescent bipolar disorderProbe taskEmotional facesPrefrontal activityNeural processingSpaced stimuliABD groupEmotional responsesProcessing regionsBilateral amygdalaDisorder exhibitMixed mood statesMood statesHealthy controlsNeural activityBipolar disorder exhibitDecoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity. PLOS Computational Biology 2012, 8: e1002441. PMID: 22479172, PMCID: PMC3315448, DOI: 10.1371/journal.pcbi.1002441.Peer-Reviewed Original ResearchConceptsFearful facesEmotional expressionBilateral middle temporal gyrusThreat-related stimuliUnattended fearful facesLarge-scale functional connectivityMultiple functional connectionsFunctional magnetic resonanceWhole-brain patternsMiddle temporal gyrusWhole-brain correlationActive research goalNeutral facesEmotion processingFear perceptionImplicit fearImplicit presentationAngular gyrusChance accuracyTemporal gyrusBrain activityFace presentationPrefrontal cortexParietal regionsFunctional connectivityInvestigating associations between empathy, morality and psychopathic personality traits in the general population
Seara-Cardoso A, Neumann C, Roiser J, McCrory E, Viding E. Investigating associations between empathy, morality and psychopathic personality traits in the general population. Personality And Individual Differences 2012, 52: 67-71. DOI: 10.1016/j.paid.2011.08.029.Peer-Reviewed Original ResearchAffective-interpersonal featuresEmpathic concernUnique varianceEmpathic responsesPsychopathic personality traitsFearful facesMoral processingEmpathy processingHappy storiesPsychopathic traitsPersonality traitsAffective aspectsCore featuresPsychopathic personalityWide batteryMoral dilemmasPrevious researchLess difficultyEmpathyPsychopathyPreliminary findingsShort formJoint varianceDeficitsProcessing
2009
Individual Differences in Personality Predict How People Look at Faces
Perlman SB, Morris JP, Vander Wyk B, Green SR, Doyle JL, Pelphrey KA. Individual Differences in Personality Predict How People Look at Faces. PLOS ONE 2009, 4: e5952. PMID: 19543398, PMCID: PMC2695783, DOI: 10.1371/journal.pone.0005952.Peer-Reviewed Original ResearchConceptsPersonality traitsIndividual differencesSocial behaviorEmotional facial expressionsPrevious behavioral researchSpecific personality traitsFearful facesSocial cognitionEmotional informationVisual scanpathsNegative emotionalityAmygdala reactivityRelevant stimuliFacial expressionsEye gazeInterpersonal interactionsEye contactEye trackingBehavioral linkBehavioral researchPersonalityNeuroticismBrain functionSerotonin transporter geneContextual determinants
2007
Influence of attentional demands on the processing of emotional facial expressions in the amygdala
Silvert L, Lepsien J, Fragopanagos N, Goolsby B, Kiss M, Taylor J, Raymond J, Shapiro K, Eimer M, Nobre A. Influence of attentional demands on the processing of emotional facial expressions in the amygdala. NeuroImage 2007, 38: 357-366. PMID: 17870614, DOI: 10.1016/j.neuroimage.2007.07.023.Peer-Reviewed Original ResearchConceptsFace stimuliAttentional resourcesAttentional loadOrientation taskProcessing of threat-related stimuliProcessing of emotional facial expressionsAvailability of attentional resourcesInfluence of attentional demandsThreat-related stimuliEmotional facial expressionsIdentity-matching taskPatterns of activityFearful facesNeutral facesRight amygdalaEmotional processingAttentional demandsPeripheral facesAmygdalaCortical regionsIdentical tasksFacial expressionsStimuliFace recognition performanceReaction time
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