2025
Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition
Pinciotti C, Avery J, Zhang C, Muñoz J, Berrones D, Cruz V, Wiese A, Anderberg J, Frederick R, Miño T, Lanzagorta N, Castro J, Ochoa-Panaifo M, Goodman W, Crowley J, Storch E, Cervin M, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, L M, Anderberg J, Aponte D, Espinosa A, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Cervin M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Río D, Dev A, Diaz S, Fay L, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Gil-Hernández D, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Jagannathan N, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McCarty R, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz M, Muñoz M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Sossa N, Pereira S, Morales N, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Prieto M, Qiao T, Quiroz-Padilla M, Quispe-Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez-Suyo M, Mellstrieng A, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, Rosario M, Sampaio A, Saraiva L, Shavitt R. Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition. Journal Of Affective Disorders 2025, 119719. PMID: 40541829, DOI: 10.1016/j.jad.2025.119719.Peer-Reviewed Original ResearchYale-Brown Obsessive Compulsive ScaleY-BOCS-IIObsessive-compulsive disorderYale-Brown Obsessive Compulsive Scale - Second EditionSeverity of obsessive-compulsive disorderSample of OCD patientsObsessive Compulsive ScaleResearch settingsOCD presentationsOCD severityCompulsive ScaleObsessive-CompulsiveOCD patientsPsychometric propertiesDiverse sampleSeveral benchmarksEmpirical critiqueHoldout sampleSeverityScoresDisordersAge groups
2019
Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Shannahoff-Khalsa D, Fernandes RY, de B. Pereira C, March JS, Leckman JF, Golshan S, Vieira MSR, Polanczyk GV, Miguel EC, Shavitt RG. Kundalini Yoga Meditation Versus the Relaxation Response Meditation for Treating Adults With Obsessive-Compulsive Disorder: A Randomized Clinical Trial. Frontiers In Psychiatry 2019, 10: 793. PMID: 31780963, PMCID: PMC6859828, DOI: 10.3389/fpsyt.2019.00793.Peer-Reviewed Original ResearchY-BOCS scoresFirst-line therapyObsessive-compulsive disorderClinical trialsSecondary measuresY-BOCSShort Form-36 Health SurveyBaseline Y-BOCS scoresCompulsive ScaleGreater improvementRelative efficacyClinical Global ImpressionEffective treatment scheduleYale-Brown Obsessive Compulsive ScaleHigh psychosocial impairmentBeck Depression InventoryBeck Anxiety InventoryLife-long disorderObsessive Compulsive ScaleYale-Brown ObsessiveYoga meditationLine therapyPrimary outcomeTreat analysisReuptake inhibitors
2018
Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study
MacLaren Kelly J, Kertz S, Simpson R, Bloch M, Pittenger C. Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study. Journal Of Technology In Behavioral Science 2018, 4: 297-302. DOI: 10.1007/s41347-018-0078-y.Peer-Reviewed Original ResearchObsessive-compulsive disorderExperience-sampling methodRecall biasesRetrospective ratingsExperience Sampling StudyParticipants' retrospective ratingsSymptom severityOCD symptom severityYale-Brown Obsessive Compulsive ScalePotential recall biasesObsessive Compulsive ScaleRetrospective biasesCompulsive disorderSymptom changeCompulsive ScaleRetrospective reportsCurrent studyBiasesDistressRecall biasRetrospective estimatesProgress monitoringFuture directionsRatingsSymptom assessment
2016
Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections
Williams KA, Swedo SE, Farmer CA, Grantz H, Grant PJ, D’Souza P, Hommer R, Katsovich L, King RA, Leckman JF. Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 860-867.e2. PMID: 27663941, DOI: 10.1016/j.jaac.2016.06.017.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersIntravenous immunoglobulinAutoimmune neuropsychiatric disordersYale-Brown Obsessive Compulsive ScaleChildren's Yale-Brown Obsessive Compulsive ScaleStreptococcal infectionIVIG groupPlacebo groupObsessive-compulsive disorderClinical Global Impression improvement ratingNeuropsychiatric disordersDouble-blind infusionDouble-blind phaseSustained symptom improvementDouble-blind comparisonOpen-label treatmentPrimary outcome measureSevere obsessive-compulsive disorderCY-BOCS total scoreCross-reactive antibodiesIdentification of biomarkersCY-BOCS scoresObsessive Compulsive ScaleImmunomodulatory therapyControlled TrialsEarly onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis.
Issari Y, Jakubovski E, Bartley CA, Pittenger C, Bloch MH. Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis. The Journal Of Clinical Psychiatry 2016, 77: e605-11. PMID: 27249090, DOI: 10.4088/jcp.14r09758.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsYale-Brown Obsessive Compulsive ScalePlacebo-controlled trialSerotonin reuptake inhibitorsTreatment of adultsObsessive-compulsive disorderSSRI responseSSRI treatmentReuptake inhibitorsSymptom improvementEfficacy of SSRIsTrials of SSRIsFirst-line pharmacologic treatmentCochrane Central RegisterStart of treatmentMajor depressive disorderEffect of doseObsessive Compulsive ScaleSSRI actionCentral RegisterPharmacologic treatmentPrimary outcomeControlled TrialsSSRI trialDepressive disorder
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbiditiesSensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials
Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, Vitiello B, McDougle C. Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism 2015, 20: 145-152. PMID: 25882391, DOI: 10.1177/1362361315574889.Peer-Reviewed Original Research
2014
Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder.
Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. Journal Of Neurosurgery 2014, 121: 123-30. PMID: 24702323, DOI: 10.3171/2014.2.jns131423.Peer-Reviewed Original ResearchConceptsLimbic system surgeryClinical outcomesWorse responseMean Y-BOCS scoreTreatment-refractory obsessive-compulsive disorderSymptom dimensionsPreoperative symptom severityWorse clinical outcomesTreatment-refractory patientsYale-Brown Obsessive Compulsive ScaleY-BOCS scoresSymptom Checklist scoresHoarding dimensionObsessive Compulsive ScaleSurgery needObsessive-compulsive disorderSurgical modalitiesAblative surgeryPoor responseWorse outcomesTreatment outcomesDimensional Yale-Brown Obsessive Compulsive ScaleYBOCS scoresPatientsSurgeryThe relationship of self-reported subclinical obsessive-compulsive symptoms and impulsivity among adults with AD/HD
Brown FC, Katz LJ, Roth RM, Beers SR. The relationship of self-reported subclinical obsessive-compulsive symptoms and impulsivity among adults with AD/HD. Psychiatry Research 2014, 216: 131-136. PMID: 24556290, DOI: 10.1016/j.psychres.2014.01.034.Peer-Reviewed Original ResearchConceptsSubclinical obsessive-compulsive symptomsAD/HDResponse inhibition difficultiesObsessive-compulsive symptomsInhibition difficultiesAttention-deficit/hyperactivity disorderBrown Attention-Deficit Disorder ScaleDeficit/hyperactivity disorderAttention Deficit Disorder ScaleMore commission errorsContinuous Performance TestPerformance-based testsObsessive Compulsive ScaleHyperactivity disorderCommission errorsDisorder ScaleSCL-90Obsessive symptomsCPT IIHigher scoresSecond editionPerformance testsIndividualsAdultsImpulsivity
2013
Exposure and response prevention with or without parent management training for children with obsessive-compulsive disorder complicated by disruptive behavior: A multiple-baseline across-responses design study
Sukhodolsky DG, Gorman BS, Scahill L, Findley D, McGuire J. Exposure and response prevention with or without parent management training for children with obsessive-compulsive disorder complicated by disruptive behavior: A multiple-baseline across-responses design study. Journal Of Anxiety Disorders 2013, 27: 298-305. PMID: 23602943, DOI: 10.1016/j.janxdis.2013.01.005.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleParent management trainingWeekly sessionsResponse preventionWeek waiting periodYale-Brown Obsessive Compulsive ScaleDisruptive behaviorExposure-based cognitive-behavioral treatmentDisruptive behavior disordersCY-BOCS scoresObsessive Compulsive ScaleObsessive-compulsive disorderCognitive-behavioral treatmentPercent reductionWeekly ratingsOutcome assessmentExperienced cliniciansBehavior disorderTreatment assignmentBehavioral treatmentCompulsive ScaleSingle-subject studyWaiting periodExposure activitiesChildren
2011
Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research Consortium
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean score
2008
Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities
2007
Positive Effects of Methylphenidate on Inattention and Hyperactivity in Pervasive Developmental Disorders: An Analysis of Secondary Measures
Posey D, Aman M, McCracken J, Scahill L, Tierney E, Arnold L, Vitiello B, Chuang S, Davies M, Ramadan Y, Witwer A, Swiezy N, Cronin P, Shah B, Carroll D, Young C, Wheeler C, McDougle C. Positive Effects of Methylphenidate on Inattention and Hyperactivity in Pervasive Developmental Disorders: An Analysis of Secondary Measures. Biological Psychiatry 2007, 61: 538-544. PMID: 17276750, DOI: 10.1016/j.biopsych.2006.09.028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolCross-Over StudiesDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMethylphenidatePsychiatric Status Rating ScalesSurveys and QuestionnairesConceptsYale-Brown Obsessive Compulsive ScaleOppositional defiant disorderAttention-deficit/hyperactivity disorderPervasive developmental disorderSequence of placeboChildren's Yale-Brown Obsessive Compulsive ScaleSignificant interindividual variabilityDevelopmental disordersObsessive Compulsive ScaleCrossover studyPelham QuestionnaireOutcome measuresRepetitive behaviorsSecondary measuresMethylphenidate dosesSecondary analysisInterindividual variabilityMethylphenidateDSM-IVDifferent dosesSymptom domainsCompulsive ScaleHyperactivity disorderSymptomsDisorders
2006
Children's Yale-Brown Obsessive Compulsive Scale Modified for Pervasive Developmental Disorders
SCAHILL L, MCDOUGLE CJ, WILLIAMS SK, DIMITROPOULOS A, AMAN MG, MCCRACKEN JT, TIERNEY E, ARNOLD LE, CRONIN P, GRADOS M, GHUMAN J, KOENIG K, LAM KS, MCGOUGH J, POSEY DJ, RITZ L, SWIEZY NB, VITIELLO B. Children's Yale-Brown Obsessive Compulsive Scale Modified for Pervasive Developmental Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 2006, 45: 1114-1123. PMID: 16926619, DOI: 10.1097/01.chi.0000220854.79144.e7.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScalePervasive developmental disorderYale-Brown Obsessive Compulsive ScaleRepetitive behaviorsYale-Brown Obsessive Compulsive Scale ModifiedDevelopmental disordersPediatric Psychopharmacology Autism NetworkLower adaptive functioningInternal consistencyMeasures of irritabilityMedication-free childrenExcellent internal consistencyObsessive Compulsive ScalePersonality traits after recovery from eating disorders: Do subtypes differ?
Wagner A, Barbarich‐Marsteller N, Frank G, Bailer U, Wonderlich S, Crosby R, Henry S, Vogel V, Plotnicov K, McConaha C, Kaye W. Personality traits after recovery from eating disorders: Do subtypes differ? International Journal Of Eating Disorders 2006, 39: 276-284. PMID: 16528697, DOI: 10.1002/eat.20251.Peer-Reviewed Original ResearchConceptsBulimia nervosaPersonality traitsState-Trait Anxiety InventoryLatent profile analysisYale-Brown Obsessive Compulsive ScaleEating Disorder ScaleCornell Eating Disorder ScaleSpielberger State-Trait Anxiety InventorySubtypes of EDObsessive Compulsive ScaleCluster B personality disordersPersonality variablesStructured Clinical InterviewB personality disordersBeck Depression InventoryCharacter InventoryAnxiety InventoryYale-BrownDisorder subtypesDisorder ScaleCompulsive ScaleClinical InterviewDepression InventoryPersonality disorderSimilar scores
2005
Measuring Change in OCD: Sensitivity of the Obsessive-Compulsive Inventory-Revised
Abramowitz J, Tolin D, Diefenbach G. Measuring Change in OCD: Sensitivity of the Obsessive-Compulsive Inventory-Revised. Journal Of Psychopathology And Behavioral Assessment 2005, 27: 317-324. DOI: 10.1007/s10862-005-2411-y.Peer-Reviewed Original ResearchObsessive-Compulsive InventoryYale-Brown Obsessive Compulsive ScaleMeasures of OCDCognitive behavioral therapySelf-report measuresObsessive-compulsive disorder severityObsessive Compulsive ScaleResponse preventionOCD symptomsNaturalistic outcome studyOCD patientsDisorder severityGlobal functioningCompulsive ScaleOCDRelated symptomsSymptom InterviewOCIInventoryOutcome studiesTreatment effectsAnxietyMeasuresRevisedFunctioningChronic tics and Tourette syndrome in patients with obsessive–compulsive disorder
Diniz J, Rosario-Campos M, Hounie A, Curi M, Shavitt R, Lopes A, Miguel E. Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. Journal Of Psychiatric Research 2005, 40: 487-493. PMID: 16289552, DOI: 10.1016/j.jpsychires.2005.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChi-Square DistributionChildDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedMultivariate AnalysisObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesPsychometricsRetrospective StudiesSeverity of Illness IndexTic DisordersTourette SyndromeConceptsObsessive-compulsive disorderTourette syndromeOCD patientsVocal ticsYale Global Tic Severity ScaleNumber of comorbiditiesStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleSymptom onsetChronic motorTic disordersCommon disorderSeverity ScalePatientsClinical InterviewChronic ticsDSM-IVBehaviors InterviewCompulsive ScaleSomatic obsessionsDisordersCompulsive disorderOCD phenotypeRiluzole Augmentation in Treatment-Resistant Obsessive–Compulsive Disorder: An Open-Label Trial
Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH. Riluzole Augmentation in Treatment-Resistant Obsessive–Compulsive Disorder: An Open-Label Trial. Biological Psychiatry 2005, 58: 424-428. PMID: 15993857, DOI: 10.1016/j.biopsych.2005.04.043.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresYale-Brown Obsessive Compulsive ScaleTreatment-resistant OCD patientsAddition of riluzolePractical clinical benefitOpen-label trialGlutamate-modulating agentsSerious adverse effectsHamilton Depression InventoryAnxiety Inventory scoresObsessive Compulsive ScaleMost patientsStandard therapyGlutamatergic dysfunctionAugmentation therapyClinical benefitPrimary diagnosisStandard treatmentCorticostriatal pathwayTreatment respondersRiluzolePatientsDepression InventoryRisperidone for the Core Symptom Domains of Autism: Results From the Study by the Autism Network of the Research Units on Pediatric Psychopharmacology
McDougle CJ, Scahill L, Aman MG, McCracken JT, Tierney E, Davies M, Arnold LE, Posey DJ, Martin A, Ghuman JK, Shah B, Chuang SZ, Swiezy NB, Gonzalez NM, Hollway J, Koenig K, McGough JJ, Ritz L, Vitiello B. Risperidone for the Core Symptom Domains of Autism: Results From the Study by the Autism Network of the Research Units on Pediatric Psychopharmacology. American Journal Of Psychiatry 2005, 162: 1142-1148. PMID: 15930063, DOI: 10.1176/appi.ajp.162.6.1142.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntipsychotic AgentsAutistic DisorderChildCommunication DisordersConduct DisorderDouble-Blind MethodFemaleHumansInterpersonal RelationsMalePersonality InventoryPlacebosPsychiatric Status Rating ScalesRisperidoneStereotyped BehaviorStereotypic Movement DisorderTreatment OutcomeConceptsYale-Brown Obsessive Compulsive ScaleChildren's Yale-Brown Obsessive Compulsive ScaleRitvo-Freeman Real Life Rating ScaleObsessive Compulsive ScaleBehavior domainsVineland Adaptive Behavior ScalesCompulsive ScaleCore symptom domainsAdaptive Behavior ScalesSensory-motor behaviorsSelf-injurious behaviorCommunicative impairmentsAutistic childrenSocial relatednessAutism NetworkRating ScaleCommunication impairmentsSevere tantrumsCore symptomsBehavior ScaleSocial interactionAutistic disorderAutismSymptom domainsLife Rating Scale
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