2025
Chapter 52 Obsessive–compulsive disorder
Abdallah S, Olfson E, Fernandez T. Chapter 52 Obsessive–compulsive disorder. 2025, 937-950. DOI: 10.1016/b978-0-443-19176-3.00011-x.ChaptersObsessive-compulsive disorderObsessive-compulsive disorder etiologiesCognitive behavioral therapySerotonin reuptake inhibitorsReuptake inhibitorsBehavioral therapyMedication augmentationNeuroanatomical alterationsNeurochemical imbalanceMedication trialsGenetic influencesImprove treatment outcomesEvidence-based therapeutic strategiesTreatment outcomesRobust clinical trialsDisordersClinical manifestationsTreatment optionsClinical trialsTherapeutic strategiesSerotoninMultifactorial naturePharmacotherapyNeuromodulationTrials
2024
Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions
Shin H, Nam M, Lee S, Yang S, Yang E, Jung J, Kim H, Woo J, Cho Y, Yoon Y, Cho I. Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions. Nature Communications 2024, 15: 10423. PMID: 39613730, PMCID: PMC11607408, DOI: 10.1038/s41467-024-54759-0.Peer-Reviewed Original ResearchConceptsBrain regionsBrain modulesModulation of brain functionTranscranial brain stimulationMultiple brain regionsUpconversion particlesSymptoms of Parkinson's diseaseOptical crosstalkStudy of neural circuitsFood competition testBrain dysfunctionExternal light sourceLight sourcesBrain functionStudy of complex behaviorsSpatial resolutionNeural circuitsBrain disordersDevelopment of treatmentsOptogenetic techniquesBrain stimulationNeural populationsBrainParkinson's diseaseNeuromodulationAntagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance
Marquina-Solis J, Feng L, Vandewyer E, Beets I, Hawk J, Colón-Ramos D, Yu J, Fox B, Schroeder F, Bargmann C. Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance. Cell Reports 2024, 43: 114042. PMID: 38573858, PMCID: PMC11063628, DOI: 10.1016/j.celrep.2024.114042.Peer-Reviewed Original ResearchConceptsFLP-1 neuropeptidesBacterium Pseudomonas aeruginosa PA14Pathogen avoidanceGrowth factor BNematode Caenorhabditis elegansC. elegansCaenorhabditis elegansAvoidance signalPathogen infectionFlp-1NeuropeptidePathogensNeuronsMultiple mechanismsMultiple neuronsInfectionNeuromodulationPromote recoveryFactor BAvoidance behaviorAVKPA14
2022
Update on Gambling Disorder
Stefanovics EA, Potenza MN. Update on Gambling Disorder. Psychiatric Clinics Of North America 2022, 45: 483-502. PMID: 36055734, DOI: 10.1016/j.psc.2022.04.004.Peer-Reviewed Original ResearchConceptsTreatment of GDGambling disorderClinical trialsPsychiatric disordersPossible treatmentAdult populationNoninvasive neuromodulationBehavioral interventionsSpecific populationsDisordersTreatmentFormal indicationImproved identificationMedicationsEtiologyPopulationNeuromodulationEnvironmental factorsTrialsPreventionUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Original ResearchConceptsEnvironmental insultsMore superficial layersDorsolateral prefrontal cortexPrimate dlPFCInflammatory mechanismsInflammatory insultKynurenic acidNMDA receptorsReceptor neurotransmissionDendritic spinesLayer IIICAMP/PKAGlutamatergic synapsePrefrontal cortexInsultPotassium channelsNeurotransmissionCalcium signalingSynapsesGenetic insultsSuperficial layersSchizophreniaSpineCortexNeuromodulation
2020
The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?
Hasegawa H, Selway R, Gnoni V, Beniczky S, Williams SCR, Kryger M, Ferini-Strambi L, Goadsby P, Leschziner GD, Ashkan K, Rosenzweig I. The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia? Sleep Medicine Reviews 2020, 52: 101317. PMID: 32446196, PMCID: PMC7679363, DOI: 10.1016/j.smrv.2020.101317.Peer-Reviewed Original ResearchConceptsBasal gangliaBasal ganglia disordersFunctional anatomyPhysiology of sleepSlow-wave sleepSleep-wake cycleOptogenetic mappingNeuromodulation strategiesSleep disordersREM sleepGangliaNeural plasticityNeural circuitsSleepFunctional imagingIntracranial recordingsHuman sleep disordersSleep mechanismsDisordersEmotional networkIntegral roleAnatomyBetter understandingNeuromodulationNeuromodulation of Brain State and Behavior
McCormick D, Nestvogel D, He B. Neuromodulation of Brain State and Behavior. Annual Review Of Neuroscience 2020, 43: 1-25. PMID: 32250724, DOI: 10.1146/annurev-neuro-100219-105424.Peer-Reviewed Original Research
2015
Ethics of neuromodulation in psychiatry
Fins J, Pohl B. Ethics of neuromodulation in psychiatry. 2015, 15-26. DOI: 10.1002/9781118801086.ch2.Peer-Reviewed Original ResearchSevere psychiatric illnessHealth care systemNeuropsychiatric conditionsPsychiatric illnessPervasive stigmaMental illnessCare systemDeep brain stimulationBrain stimulationClinical ethicsMoral dilemmasDerivative questionsIllnessEthicsDevice regulationNeuromodulationTranslational researchClinical needPsychiatryStigmaHealthBrainIntervention
2011
A neuromodulation experience registry for deep brain stimulation studies in psychiatric research: Rationale and recommendations for implementation
Synofzik M, Fins J, Schlaepfer T. A neuromodulation experience registry for deep brain stimulation studies in psychiatric research: Rationale and recommendations for implementation. Brain Stimulation 2011, 5: 653-655. PMID: 22100456, DOI: 10.1016/j.brs.2011.10.003.Peer-Reviewed Original Research
2004
Neuromodulation, free will and determinism: lessons from the psychosurgery debate
Fins J. Neuromodulation, free will and determinism: lessons from the psychosurgery debate. Clinical Neuroscience Research 2004, 4: 113-118. DOI: 10.1016/j.cnr.2004.06.011.Peer-Reviewed Original Research
2003
From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
Fins J. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurgery Clinics Of North America 2003, 14: 303-319. PMID: 12856496, DOI: 10.1016/s1042-3680(02)00118-3.Peer-Reviewed Original ResearchConceptsPsychiatric illnessDeep brain stimulationObsessive-compulsive disorderEra of psychosurgerySevere psychiatric illnessTreat psychiatric illnessBrain stimulationTreatment of Parkinson's diseaseModulation of consciousnessTraumatic brain injurySomatic therapiesNeuropsychiatric researchPrefrontal lobotomyBrain injuryCongressional callsPsychosurgeryParkinson's diseaseImplanted deep brain stimulationNeuromodulationIllnessHistory lessonsPsychiatristsPsychiatryLobotomyWidespread condemnation
2001
Neuromodulation: Mechanisms of Induced Changes in the Electrical Behavior of Nerve Cells
B.Levitan I, Kaczmarek L. Neuromodulation: Mechanisms of Induced Changes in the Electrical Behavior of Nerve Cells. 2001, 315-340. DOI: 10.1093/oso/9780195145236.003.0013.Peer-Reviewed Original ResearchNervous systemNerve cellsElectrical activityAction potential firingNeuronal electrical propertiesEndogenous electrical activityA11 neuronsSynaptic stimulationAction potentialsHormonal stimulationDifferent patternsNeuronsIon channelsStimulationSuch modulationTransduction mechanismsCellsNeuromodulationActivity
1992
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
McCormick D. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Progress In Neurobiology 1992, 39: 337-388. PMID: 1354387, DOI: 10.1016/0301-0082(92)90012-4.Peer-Reviewed Original Research
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