2025
Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder
Abdallah S, Olfson E, Cappi C, Greenspun S, Zai G, Rosário M, Willsey A, Shavitt R, Miguel E, Kennedy J, Richter M, Fernandez T. Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40122455, DOI: 10.1016/j.jaac.2025.03.014.Peer-Reviewed Original ResearchCopy-number variantsWhole-exome DNA sequencingEXome-Hidden Markov ModelDetect copy-number variantsSingle-nucleotide variantsGenetic factorsWhole-exome sequencingExamination of genesBiological systems analysisTrio familiesDNA sequencesMicroarray dataOCD riskBurden analysisBiological processesGenesSequenceVariantsObsessive-compulsive disorderPrimary analysisXHMMPediatric obsessive-compulsive disorderCompared to controlsFamilySilicoThirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis
Freund J, Gosalvez C, Rady A, Notarianni A, Carr Z. Thirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis. Anesthesiology And Perioperative Science 2025, 3: 9. DOI: 10.1007/s44254-025-00087-5.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsPostoperative cardiopulmonary complicationsLength of staySarcoidosis patientsSarcoidosis diagnosisCardiopulmonary complicationsCohort analysisAssociated with 30-day MACEIndependent of disease stageSystemic granulomatous disorderRetrospective matched cohort analysisMethodsThis retrospective studyAssociated with higher riskCongestive heart failure eventsComparative cohort analysisHeart failure eventsPreoperative chest radiographyAdverse cardiovascular eventsMatched Cohort AnalysisCompared to controlsPulmonary complicationsSarcoidosis cohortGranulomatous disorderLung involvementThirty-day
2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive healthReorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsInfusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating MarkersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaComputational Modeling of Sodium Fluorescein Disposition in Ex Vivo, Machine-Perfused Livers with Ischemia-Reperfusion Injury
Monti C, Audi S, Hong S, Yang Y, Kim J, Dash R. Computational Modeling of Sodium Fluorescein Disposition in Ex Vivo, Machine-Perfused Livers with Ischemia-Reperfusion Injury. Physiology 2024, 39: 566. DOI: 10.1152/physiol.2024.39.s1.566.Peer-Reviewed Original ResearchMultidrug resistance protein 2Warm ischemia timeCold ischemia timeIncreased WITSodium fluoresceinIschemia timeMachine perfusionSprague-Dawley ratsIschemia-reperfusion injuryClearance dataBile-to-plasmaMaximal transport velocityCompared to controlsTotal hepatectomyLiver viabilityHepatic arteryPortal veinTransport activity in vivoIschemia-reperfusionActivity in vivoIRI conditionsRelative to controlsEx vivoBiliary functionClearance kineticsKidney Stones Account for Increased Imaging Studies in Autosomal Dominant Polycystic Kidney Disease
Simmons K, Ullman L, Dahl N. Kidney Stones Account for Increased Imaging Studies in Autosomal Dominant Polycystic Kidney Disease. Kidney360 2024, 5: 707-714. PMID: 38526140, PMCID: PMC11146651, DOI: 10.34067/kid.0000000000000424.Peer-Reviewed Original ResearchAbdominal imaging studiesChronic kidney diseaseADPKD patientsImaging studiesKidney stonesChronic kidney disease controlKidney diseaseChronic kidney disease groupIncreased incidence of kidney stonesChronic kidney disease populationChronic kidney disease stagePreserved renal functionRetrospectively reviewed patientsAutosomal dominant polycystic kidney diseaseIncidence of kidney stonesDominant polycystic kidney diseaseChi-square and t-testsCoronary artery diseasePolycystic kidney diseaseCompared to controlsCyst complicationsRenal functionChart reviewLower BMIManual chart review
2021
Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells
Atif F, Yousuf S, Espinosa-Garcia C, Stein D. Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells. Molecular Neurobiology 2021, 58: 3805-3816. PMID: 33847913, DOI: 10.1007/s12035-021-02382-1.Peer-Reviewed Original ResearchConceptsExtracellular acidification rateEffects of P4Glioblastoma multiformeGlioblastoma multiforme cell linesGlioblastoma multiforme cellsCell linesInhibitory effectDecreased tumor sizeSuperoxide radical generationMitochondrial functionDose-dependent inhibitory effectOxygen consumption rateTime-response studiesMitochondrial respirationHuman glioblastoma multiformeMitochondrial stress testSpread of glioblastoma multiformeCompared to controlsTumor sizeConcentrations of P4Human glioblastoma cellsModulate mitochondrial functionNonmitochondrial oxygen consumptionMaximum inhibitory effectDose responseThe Association of Fetal Congenital Cardiac Defects and Placental Vascular Malperfusion
Ozcan T, Kikano S, Plummer S, Strainic J, Ravishankar S. The Association of Fetal Congenital Cardiac Defects and Placental Vascular Malperfusion. Pediatric And Developmental Pathology 2021, 24: 187-192. PMID: 33491545, DOI: 10.1177/1093526620986497.Peer-Reviewed Original ResearchConceptsFetal congenital heart defectsFetal vascular malperfusionCongenital heart defectsPlacental perfusion defectsMaternal risk factorsRisk factorsVascular malperfusionCompared to controlsVentricle morphologyGroup 2Group 1Congenital heart defect groupsCongenital heart defect casesPlacental vascular malperfusionCongenital cardiac defectsSingle right ventricleMaternal malperfusionSingleton pregnanciesPlacental disordersCardiac defectsHeart defectsCongenital anomaliesRight ventriclePerfusion defectsGreat vessels
2019
HOUT-29. THE INFLUENCE OF PSYCHIATRIC ILLNESS ON OUTCOME AND CANCER CARE RECEIVED IN PATIENTS WITH GLIOMAS
Patel P, Li T, Chou J, Patel A, Crispino S, Utate M, Kurz S. HOUT-29. THE INFLUENCE OF PSYCHIATRIC ILLNESS ON OUTCOME AND CANCER CARE RECEIVED IN PATIENTS WITH GLIOMAS. Neuro-Oncology 2019, 21: vi118-vi118. PMCID: PMC6846933, DOI: 10.1093/neuonc/noz175.494.Peer-Reviewed Original ResearchCancer carePsychiatric illnessPsychiatric diagnosisTumor diagnosisFollow-upPrevalence of psychiatric disordersPresence of psychiatric illnessKaplan-Meier methodPsychiatric disordersPsychiatric conditionsTime of diagnosisSubstance use problemsCompared to controlsAnaplastic oligodendrogliomaMedical careAnaplastic astrocytomaIntracranial gliomasCompare complianceAdjustment disorderIncreased riskPoor complianceGlioma patientsCompare survivalCarePatients
2010
Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene
Das D, Bhattacharjee B, Sen S, Mukhopadhyay I, Sengupta S. Association of viral load with HPV16 positive cervical cancer pathogenesis: Causal relevance in isolates harboring intact viral E2 gene. Virology 2010, 402: 197-202. PMID: 20394955, DOI: 10.1016/j.virol.2010.03.030.Peer-Reviewed Original ResearchConceptsViral loadE2 statusAssociation of viral loadMedian viral loadViral loads compared to controlsAge of subjectsCervical cancer pathogenesisViral E2 geneCompared to controlsCervical cancerLogistic regression modelsCancer pathogenesisTaqMan assayLower ageCaCxHPV16E2 genePathogenesisAgeIntact E2Regression modelsStatusGenomic DNAAssociationCancer
2005
HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women
Bhattacharjee B, Sengupta S. HPV16 E2 gene disruption and polymorphisms of E2 and LCR: Some significant associations with cervical cancer in Indian women. Gynecologic Oncology 2005, 100: 372-378. PMID: 16246404, DOI: 10.1016/j.ygyno.2005.09.016.Peer-Reviewed Original ResearchConceptsE2 disruptionE2 geneE2 gene disruptionIntact E2 geneIndian womenBi-directional sequencingAsian-American variantsNucleotide sequence alterationsDNA-binding regionHPV16 E2 geneCaCx developmentHPV16 isolatesCompared to controlsChi-square testCaCx casesFisher's exactCervical cancerViral factorsHPV16Nucleotide variationsE subgroupGene disruptionSequence alterationsPCR amplificationNucleotide
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