2013
Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation
Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane‐wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation. The FASEB Journal 2013, 28: 908-922. PMID: 24221087, PMCID: PMC3898640, DOI: 10.1096/fj.13-238527.Peer-Reviewed Original ResearchConceptsHuman umbilical vein ECsEndothelial cellsMiR-132MicroRNA-132Cultured human umbilical vein endothelial cellsNumber of microvesselsGrowth factor-induced proliferationHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsEndothelial cell transplantationCultured endothelial cellsEndogenous growth factorsEC transplantationVein endothelial cellsCell transplantationImmunodeficient miceTissue perfusionTransplantationMiR deliveryGrowth factorIntegrin αvβ3Endocytosed nanoparticlesSquare millimeterBiological effectsControl transfection
2012
miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons
Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons. PLOS ONE 2012, 7: e38174. PMID: 22693596, PMCID: PMC3364964, DOI: 10.1371/journal.pone.0038174.Peer-Reviewed Original ResearchConceptsOlfactory bulb neuronsSynaptic integrationMiR-132Bulb neuronsSpine densityFrequency of GABAergicGlutamatergic synaptic inputsSubventricular zone neurogenesisMiR-132 overexpressionMiR-132 expressionMicroRNA miR-132Neonatal SVZTransplanted neuronsDendritic complexityNewborn neuronsNeuronal survivalPostnatal neurogenesisSynaptic inputsTransplant therapyDendritic morphogenesisNeuronsVivo electroporationSurvivalSignificant increasePlasticity program
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