2023
Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice
Carrette L, Kimbrough A, Davoudian P, Kwan A, Collazo A, George O. Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice. ENeuro 2023, 10: eneuro.0019-23.2023. PMID: 37295945, PMCID: PMC10306126, DOI: 10.1523/eneuro.0019-23.2023.Peer-Reviewed Original ResearchConceptsWhole-brain functional connectivityCholinergic regionsCholinergic systemFunctional connectivityNicotine withdrawalMale miceFos expressionNicotinic receptorsBrain cholinergic systemWithdrawal-induced changesImmediate early gene FosDiscontinuation of useNicotinic acetylcholine receptorsBrain functional connectivityCholinergic neuronsBasal forebrainNicotine resultsWithdrawal symptomsCholinergic neurotransmissionMRNA expression databaseReceptor mRNANicotine dependenceAcetylcholine receptorsBaseline expressionBrain regions
2015
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation
Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC. Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 2015, 233: 57-70. PMID: 26423528, DOI: 10.1007/s00213-015-4086-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDesipramineExploratory BehaviorFemaleFluoxetineIndolesMiceMice, Inbred C57BLObsessive-Compulsive DisorderReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Receptor AgonistsStereotyped BehaviorTreatment OutcomeConceptsAcute treatmentFos expressionDorsal striatumOCD treatmentStriatal activationReceptor agonist treatmentEffective OCD treatmentOpen-field behaviorChronic fluoxetineAgonist treatmentObsessive-compulsive disorderChronic pretreatmentLocomotor stereotypySeparate miceNeuronal activationDrug treatmentTreatment preventsRepetitive behaviorsOCD pathophysiologyBrain regionsOrbitofrontal cortexBehavioral effectsRU24969Inhibition deficitsBrain activation
2008
Fos expression in mesocorticolimbic areas during heroin place conditioning
Honsberger M, Leri F. Fos expression in mesocorticolimbic areas during heroin place conditioning. Neuroreport 2008, 19: 63-67. PMID: 18281894, DOI: 10.1097/wnr.0b013e3282f31d82.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexConditioning compartmentPrefrontal cortexPlace conditioningMesocorticolimbic dopamine systemNeural representationAssociative learningMotivational valueNovel stimuliHigher Fos expressionNeural sitesDopamine systemStimuliMesocorticolimbic areasConditioningCortexFos expressionFirst exposureOnly region
2007
Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors
Elsworth JD, Morrow BA, Nguyen V, Mitra J, Picciotto MR, Roth RH. Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors. Neuroscience 2007, 147: 419-427. PMID: 17543464, PMCID: PMC2855228, DOI: 10.1016/j.neuroscience.2007.04.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyAutoreceptorsClonidineCocaineFemaleGenes, fosImmunohistochemistryInjections, IntravenousLocus CoeruleusMaleNeuronsNorepinephrinePrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsRadioligand AssayRatsRats, Sprague-DawleyStress, PsychologicalTyrosine 3-MonooxygenaseConceptsPrenatal cocaine exposureNorepinephrine neuronsCocaine exposurePrenatal cocaineTyrosine hydroxylase-positive neuronsLocus coeruleus norepinephrine neuronsPrenatal cocaine exposure resultsPrenatal saline controlsRole of autoreceptorsLocus coeruleus noradrenergic systemPrenatal treatment groupsCocaine exposure resultsAlpha2-adrenergic receptorsInjection of cocaineGestational day 10Pharmacology of cocaineDaily i.LC neuronsNorepinephrine turnoverPregnant ratsNeurobehavioral deficitsSaline controlsFos expressionNoradrenergic systemRat model
1999
Role of the medial prefrontal cortex in 5‐HT1A receptor‐induced inhibition of 5‐HT neuronal activity in the rat
Hajós M, Hajós‐Korcsok É, Sharp T. Role of the medial prefrontal cortex in 5‐HT1A receptor‐induced inhibition of 5‐HT neuronal activity in the rat. British Journal Of Pharmacology 1999, 126: 1741-1750. PMID: 10372816, PMCID: PMC1565963, DOI: 10.1038/sj.bjp.0702510.Peer-Reviewed Original ResearchMeSH Keywords8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsElectrophysiologyImmunohistochemistryIontophoresisMaleMicroinjectionsNeuronsOncogene Proteins v-fosParoxetinePiperazinesPrefrontal CortexPutamenPyridinesRaphe NucleiRatsRats, Sprague-DawleyReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsSerotoninSerotonin AntagonistsSerotonin Receptor AgonistsConceptsDorsal raphe nucleusReceptor-induced inhibitionCortical transectionWAY-100635Receptor agonistSystemic administrationFos expressionFrontal cortexMPFC neuronesPrefrontal cortexInhibitory effectSingle-unit recordingsMedial prefrontal cortexReuptake inhibitorsFos immunocytochemistryRaphe nucleusAnaesthetized ratsIontophoretic applicationReceptor antagonistNeuronal excitationDPATNeuronal activityHigh dosesFiring activityParietal cortex
1996
Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate
Deutch A, Lewis D, Whitehead R, Elsworth J, Iadarola M, Redmond D, Roth R. Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse 1996, 23: 182-191. PMID: 8807746, DOI: 10.1002/(sici)1098-2396(199607)23:3<182::aid-syn7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsFos-LI neuronsExtrapyramidal side effectsEffective antipsychotic drugAntipsychotic drugsEntorhinal cortexSide effectsReceptor antagonistFos expressionD2 receptorsCaudate nucleusNucleus accumbensTemporal cortexFos-like immunoreactive neuronsExtra-pyramidal side effectsD2 dopamine receptor antagonistRat striatal complexC-fosD2 receptor antagonismDorsolateral caudate nucleusDopamine receptor antagonistEffect of administrationImmediate early gene c-fosD2 receptor antagonistEarly gene c-fosFos protein expression
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