2024
Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1
Mannes P, Adams T, Farsijani S, Barnes C, Latoche J, Day K, Nedrow J, Ahangari F, Kaminski N, Lee J, Tavakoli S. Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1. Science Advances 2024, 10: eadm9817. PMID: 38896611, PMCID: PMC11186491, DOI: 10.1126/sciadv.adm9817.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisFibrotic lung diseaseRisk stratificationMurine modelLung fibrosisLung diseaseModel of bleomycin-induced lung fibrosisBleomycin-induced lung fibrosisImaging biomarkersMurine model of bleomycin-induced lung fibrosisBronchoalveolar lavage cellsMonocyte-derived macrophagesPositron emission tomographyInflammatory endotypesPulmonary fibrosisLavage cellsPoor survivalNoninvasive assessmentTherapeutic monitoringEmission tomographyCMKLR1FibrosisClinical trajectoryLungLung regions
2021
Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker
Gaurav R, Yahia‐Cherif L, Pyatigorskaya N, Mangone G, Biondetti E, Valabrègue R, Ewenczyk C, Hutchison R, Cedarbaum J, Corvol J, Vidailhet M, Lehéricy S. Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker. Movement Disorders 2021, 36: 1592-1602. PMID: 33751655, PMCID: PMC8359265, DOI: 10.1002/mds.28531.Peer-Reviewed Original ResearchConceptsTotal intracranial volumePD patientsHealthy volunteersParkinson's diseaseIntracranial volumeObservational case-control studySubstantia nigra pars compactaDirect noninvasive assessmentDisease-modifying treatmentsEarly PD patientsFemale PD patientsTherapeutic drug trialsCase-control studyNeuromelanin-sensitive MRI techniquesNeuromelanin-sensitive imagingMale patientsFemale patientsPars compactaCohort IICohort IDrug trialsPatientsImaging biomarkersNoninvasive assessmentDisease severity
2010
Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake
Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientDermal carotenoidsDermal biopsiesRR measuresBiomarkers of fruitDietary carotenoid intakeVegetable intakeCarotenoid statusCarotenoid intakeStudy of nutritionNoninvasive assessmentBiopsyBiomarkersSkin pigmentationTotal carotenoidsHuman skinIntakeWkInner armLycopeneValid methodArmLate Gadolinium Enhancement of the Esophagus is Common on Cardiac MR Several Months after Pulmonary Vein Isolation: Preliminary Observations
MENG J, PETERS DC, HSING JM, CHUANG ML, CHAN J, FISH A, JOSEPHSON ME, MANNING WJ. Late Gadolinium Enhancement of the Esophagus is Common on Cardiac MR Several Months after Pulmonary Vein Isolation: Preliminary Observations. Pacing And Clinical Electrophysiology 2010, 33: 661-666. PMID: 20059713, DOI: 10.1111/j.1540-8159.2009.02671.x.Peer-Reviewed Original ResearchConceptsPulmonary vein isolationCardiovascular magnetic resonance imagingAtrial fibrillationVein isolationLGE-CMRPost-pulmonary vein isolationLate gadolinium enhancement cardiovascular magnetic resonance imagingEnhancement cardiovascular magnetic resonance imagingFrequent imaging findingsLeft atrium cavityLate gadolinium enhancementMagnetic resonance imagingEsophageal positionImaging findingsEsophageal locationGadolinium enhancementHyperenhancementNoninvasive assessmentVertebral bodyResonance imagingClinical implicationsAblation siteLonger ablation timePatientsCardiac MR
2009
Evaluation of hepatic fibrosis with portal pressure gradient in rats
Wang Y, Booth CJ, Kim H, Qiu M, Constable RT. Evaluation of hepatic fibrosis with portal pressure gradient in rats. Magnetic Resonance In Medicine 2009, 61: 1185-1192. PMID: 19253377, PMCID: PMC11210607, DOI: 10.1002/mrm.21964.Peer-Reviewed Original ResearchConceptsHepatic fibrosisFibrosis scorePortal pressure gradientCirrhosis groupFibrosis groupLiver fibrosisLiver pathologyPortal veinHistological examinationAnimal studiesNoninvasive assessmentFibrosisNoninvasive meansGradient echo sequenceVessel areaSignificant differencesRatsContrast agentsEcho sequenceScoresCarbon tetrachlorideGroupPhantom study
2008
The Role of Imaging in Chronic Degenerative Mitral Regurgitation
O’Gara P, Sugeng L, Lang R, Sarano M, Hung J, Raman S, Fischer G, Carabello B, Adams D, Vannan M. The Role of Imaging in Chronic Degenerative Mitral Regurgitation. JACC Cardiovascular Imaging 2008, 1: 221-237. PMID: 19356431, DOI: 10.1016/j.jcmg.2008.01.011.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationCardiac Surgical ProceduresChronic DiseaseCooperative BehaviorDiagnostic ImagingEchocardiography, Doppler, ColorEchocardiography, TransesophagealHumansMitral ValveMitral Valve InsufficiencyPatient Care TeamPatient SelectionPredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexTomography, X-Ray ComputedVentricular Function, LeftConceptsChronic degenerative mitral regurgitationDegenerative mitral regurgitationMitral regurgitationMitral valveLeft ventricular systolic functionPercutaneous MV repairAssessment of etiologyVentricular systolic functionDegenerative MRMV repairMR severityValve lesionsSystolic functionClinical decision-makingNoninvasive assessmentMultidisciplinary approachRegurgitationSeverityRepairValveNoninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study
Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertility And Sterility 2008, 90: 77-83. PMID: 18281045, DOI: 10.1016/j.fertnstert.2007.11.058.Peer-Reviewed Original ResearchConceptsMetabolomic profilingProspective blinded pilot studyNoninvasive metabolomic profilingEmbryonic reproductive potentialBlinded pilot studyReproductive technology programCharacteristic curve analysisHuman embryo culture mediaOverall diagnostic accuracyViability indexImplantation rateEmbryo culture mediumMAIN OUTCOMEDay 3Noninvasive assessmentDay 5Culture mediumDiagnostic accuracyPilot studyCurve analysisSimilar findingsReproductive potentialRapid noninvasive assessmentDelivery rateHuman embryos
1997
Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study.
Hertz-Pannier L, Gaillard W, Mott S, Cuenod C, Bookheimer S, Weinstein S, Conry J, Papero P, Schiff S, Bihan D, Theodore W. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997, 48: 1003-12. PMID: 9109891, DOI: 10.1212/wnl.48.4.1003.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingElectrostimulation mappingLeft dominanceFunctional mapping techniquesMagnetic resonance imagingNoninvasive functional mappingRight-handed childrenLanguage dominanceBilateral languageHemodynamic changesEpilepsy surgeryPartial epilepsySurgery outcomesTemporal epilepsyAmobarbital testNeuronal activationWord generation taskFrontal lobeLanguage lateralizationRight dominanceNoninvasive assessmentResonance imagingFunctional MRISignal time courseBrain development
1996
Prevalence of Pulmonary Hypertension in Limited and Diffuse Scleroderma
Battle R, Davitt M, Cooper S, Buckley L, Leib E, Beglin P, Tischler M. Prevalence of Pulmonary Hypertension in Limited and Diffuse Scleroderma. CHEST Journal 1996, 110: 1515-1519. PMID: 8989070, DOI: 10.1378/chest.110.6.1515.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBlood PressureCross-Sectional StudiesEchocardiography, DopplerElectrocardiographyFemaleHumansHypertension, PulmonaryMaleMiddle AgedProspective StudiesPulmonary ArteryPulmonary Diffusing CapacityPulmonary VentilationScleroderma, SystemicTricuspid Valve InsufficiencyConceptsPulmonary artery systolic pressurePulmonary hypertensionDiffuse sclerodermaTricuspid regurgitationSignificant end-organ damageProspective cross-sectional studyTranstricuspid pressure gradientUndiagnosed pulmonary hypertensionEnd-organ damageRight atrial pressureSuccessful treatment strategyCross-sectional studyAtrial pressureMost patientsConsecutive patientsSystolic pressureDoppler echocardiogramOutpatient clinicRespiratory indexClinical signsTreatment strategiesHypertensionPatientsNoninvasive assessmentScleroderma
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