2022
Obstructive Sleep Apnea and Polycystic Ovary Syndrome
Chu Y, Hilbert J, Mohsenin V. Obstructive Sleep Apnea and Polycystic Ovary Syndrome. 2022, 393-409. DOI: 10.1007/978-3-030-92589-5_20.Peer-Reviewed Original ResearchPolycystic ovary syndromeObstructive sleep apneaCardiovascular outcomesOvary syndromeSleep apneaPathogenesis of OSAPrevalence of OSARepetitive upper airway obstructionsUntreated sleep-disordered breathingExcess of androgensUpper airway obstructionImproved cardiovascular outcomesSleep-disordered breathingSleep breathing disordersWeight-matched controlsImproved sleep qualityRates of obesityAirway obstructionNorepinephrine levelsCentral adiposityAtypical symptomsInsulin resistanceTreatment optionsSex hormonesTreatment benefitAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested Case-Control StudySymptomsCase-control studySerotonin
2014
Do Stress Markers and Anesthetic Technique Predict Delirium in the Elderly?
Deiner S, Lin H, Bodansky D, Silverstein J, Sano M. Do Stress Markers and Anesthetic Technique Predict Delirium in the Elderly? Dementia And Geriatric Cognitive Disorders 2014, 38: 366-374. PMID: 25171689, PMCID: PMC4201865, DOI: 10.1159/000363762.Peer-Reviewed Original ResearchConceptsPostoperative deliriumStress markersSurgical patientsHypothalamic-pituitary-adrenal stress responseProspective cohort studyCompare stress markersElderly surgical patientsConfusion Assessment MethodIncidence of PDRisk of PDNorepinephrine levelsSevoflurane gasAssociated with increased magnitudeCohort studyDevelopment of PDPostoperative stressSerum stress markersPatientsIntraoperative stressPredicting deliriumSurgeryMarkersNO effectAnestheticsCognitive recoveryHypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice
Kim JD, Toda C, D’Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 11876-11881. PMID: 25071172, PMCID: PMC4136568, DOI: 10.1073/pnas.1406000111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseGene ExpressionGene Knockdown TechniquesGlucagonGlucose Clamp TechniqueGlucose IntoleranceHypothalamusIndolesInsulinInsulin SecretionIon ChannelsMaleMiceMice, TransgenicMitochondrial ProteinsPancreasPhosphorylationProlyl OligopeptidasesReceptor, InsulinRecombinant ProteinsSerine EndopeptidasesSerine Proteinase InhibitorsThiazolidinesUncoupling Protein 1Ventromedial Hypothalamic NucleusConceptsWild-type miceGlucose intoleranceGlucagon secretionProlyl endopeptidaseHyperinsulinemic-euglycemic clamp studiesWild-type control miceGlucose-induced insulin releaseGlucose-induced insulin secretionEuglycemic clamp studiesAutonomic nervous systemVMH injectionsSympathetic outflowWild-type controlsNorepinephrine levelsGlucagon levelsGlucose toleranceControl miceInsulin levelsCentral infusionPancreatic functionVentromedial nucleusInsulin secretionNeuronal activationGlucose-intolerant phenotypeCentral regulation
2007
Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans
LAMPERT R, SOUFER R, McPHERSON CA, BATSFORD WP, TIRADO S, EARLEY C, GOLDBERG A, SHUSTERMAN V. Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans. Journal Of Cardiovascular Electrophysiology 2007, 18: 512-517. PMID: 17428273, DOI: 10.1111/j.1540-8167.2007.00787.x.Peer-Reviewed Original ResearchConceptsRepolarization instabilityQRS duration changesImplantable defibrillator shocksAmbulatory ECG monitoringT-wave alternansNorepinephrine levelsCoronary diseaseICD shocksSympathetic stimulationVentricular arrhythmiasInduced arrhythmiasVentricular arrhythmogenesisDefibrillator shocksQRS durationQT intervalSedated stateAdequate preClinical implicationsDefibrillation therapyECG monitoringRR intervalsHolter dataBaseline statePatientsArrhythmias
1995
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartum
1993
Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin.
Kerr D, Tamborlane WV, Rife F, Sherwin RS. Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin. Journal Of Clinical Investigation 1993, 91: 141-147. PMID: 8423214, PMCID: PMC330007, DOI: 10.1172/jci116163.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factor-1Insulin-like growth factor-1Growth factor-1Glucagon responseGlucose productionAbsent glucagon responsesPlasma glucose nadirsGrowth hormone responseInsulin-induced hypoglycemiaAwareness of hypoglycemiaGrowth hormone releaseFactor 1Hepatic glucose productionHuman insulin-like growth factor-1Recognition of hypoglycemiaSymptomatic awarenessNorepinephrine levelsCounterregulatory responsesHypoglycemic stimulusSympathetic activityGlucose nadirsGlucagon releaseBlood glucoseRebound increaseHormone release
1990
MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neuroscience Letters 1990, 114: 316-322. PMID: 2402341, DOI: 10.1016/0304-3940(90)90583-u.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDopamine innervationMotor areaParkinson's diseaseMPTP-induced degenerationStriatal dopamine innervationStriatal dopamine concentrationsAsymptomatic MPTPSymptomatic MPTPConcentration of dopamineNorepinephrine levelsNorepinephrine concentrationsCortical involvementDopaminergic innervationCingulate sulcusCingulate cortexMPTPCortical regionsDopamine concentrationsInnervationDiseaseDopamineBehavioral changesCortexDegeneration
1987
Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder
Kosten T, Mason J, Giller E, Ostroff R, Harkness L. Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder. Psychoneuroendocrinology 1987, 12: 13-20. PMID: 3588809, DOI: 10.1016/0306-4530(87)90017-5.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderEpinephrine levelsParanoid schizophreniaUndifferentiated schizophreniaUrinary norepinephrineSympathetic nervous system activityStress disorderMean epinephrine levelMean norepinephrine levelsCourse of hospitalizationNervous system activityNorepinephrine elevationNorepinephrine levelsHospital admissionPatient groupDepressive disorderHospitalizationMain underlying mechanismPTSD patientsBP groupDiagnostic groupsTwo-week intervalsPTSD groupUS group
1984
Sympathetic control of sexual reflexes: Peripheral 6-hydroxydopamine administration facilitates the onset of penile reflexes in male rats
Howard S, Lumia A, Anderson G, Shaywitz B. Sympathetic control of sexual reflexes: Peripheral 6-hydroxydopamine administration facilitates the onset of penile reflexes in male rats. Physiology & Behavior 1984, 32: 791-794. PMID: 6436843, DOI: 10.1016/0031-9384(84)90196-3.Peer-Reviewed Original ResearchConceptsControl subjectsPenile reflexesMale ratsPeripheral norepinephrine levelsSympathetic inhibitionChemical sympathectomyNorepinephrine levelsSympathetic controlSexual reflexesReflexRatsMean numberSignificant differencesFirst reflexAdministrationOne daySubjectsSalineDaysTreatmentOnsetSympathectomy
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