2000
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
Sulzer D, Bogulavsky J, Larsen K, Behr G, Karatekin E, Kleinman M, Turro N, Krantz D, Edwards R, Greene L, Zecca L. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11869-11874. PMID: 11050221, PMCID: PMC17261, DOI: 10.1073/pnas.97.22.11869.Peer-Reviewed Original ResearchConceptsCytosolic catecholaminesSubstantia nigraDisease neurodegenerationCytosolic dopamineRat substantia nigraSynaptic vesiclesParkinson's disease neurodegenerationHuman substantia nigraIron chelator desferrioxamineCatecholamine neuronsFunction of neuromelaninDeep brain regionsParkinson's diseaseAdenoviral-mediated overexpressionBrain regionsDouble-membrane autophagic vacuolesVesicular accumulationPC12 cell culturesChelator desferrioxamineDopamineNM granulesAntioxidant mechanismsPC12 cellsNeuromelaninNeurite outgrowth
1987
Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?
Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? Psychopharmacology Series 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.Peer-Reviewed Original ResearchConceptsMost psychotic patientsDA receptor blockerTreatment of choiceDopamine neuron activityCentral catecholamine systemsReceptor blockadeReceptor blockersCatecholamine neuronsNeuroleptic effectsMajor symptomsAntipsychotic drugsCatecholamine systemsAntipsychotic propertiesForebrain regionsNeuronal activityCatecholamine receptorsSide effectsDopamine systemNeuron activityPsychotic patientsTherapeutic efficacyMode of actionFeedback pathwaysTreatmentNeuroleptics
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