2022
Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes
Stewart A, Davis G, Areal L, Rabil M, Tran V, Mayer F, Blakely R. Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes. Cells 2022, 11: 4059. PMID: 36552823, PMCID: PMC9777203, DOI: 10.3390/cells11244059.Peer-Reviewed Original ResearchConceptsDAT Val559 miceAnomalous DA effluxDorsal medial striatumCompulsive behaviorsFormation of goal-directedLever-pressing paradigmDA agonist apomorphineDevaluation of rewardPairwise discrimination taskGoal-directed behaviorDendritic spine densityDAT Val559Habitual rewardAgonist apomorphineDA neurotransmissionDA effluxReward conditionCognitive flexibilityReinforcement scheduleReward motivationStriatal circuitryChecking behaviorMedial striatumPsychiatric disordersDiscrimination task
2012
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
Jiang H, Ren Y, Yuen E, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Communications 2012, 3: 668. PMID: 22314364, PMCID: PMC3498452, DOI: 10.1038/ncomms1669.Peer-Reviewed Original ResearchConceptsMidbrain DA neuronsDA neuronsParkinson's diseaseDopamine utilizationDopaminergic neuronsHuman midbrain dopaminergic neuronsSpontaneous DA releaseNigral DA neuronsNigral dopaminergic neuronsDisease-modifying therapiesMidbrain dopaminergic neuronsParkin knockout miceStem cellsPluripotent stem cellsPD patientsDA releaseDA neurotransmissionDA uptakeNormal subjectsKnockout miceParkin mutationsNovel targetNeuronsOxidative stressMonoamine oxidase
2009
Dopamine
Elsworth J, Roth R. Dopamine. 2009, 539-547. DOI: 10.1016/b978-008045046-9.00683-5.Peer-Reviewed Original ResearchCo-localized peptidesDA neuron activityDopamine cell groupsDendritic spine synapsesDifferent firing patternsSpine densityDA neurotransmissionSpine synapsesParkinson's diseaseNeuron activityVolume transmissionPharmacological perspectiveCell groupsFiring patternsEndogenous mechanismsDiseaseAutoreceptorsNeurotransmissionSchizophreniaBrainSynapses
1998
Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation
Meeker D, Kim J, Vezina P. Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation. Brain Research 1998, 812: 260-264. PMID: 9813358, DOI: 10.1016/s0006-8993(98)00941-x.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor activationDepletion of dopamineMetabotropic glutamate receptorsGlutamate receptor activationMicroinjection of salineGroups of ratsNon-lesioned animalsContribution of dopamineMGluR agonistBilateral microinjectionDA levelsMGluR activationDA neurotransmissionGlutamate receptorsNucleus accumbensMicroinjection sitesLocomotor activityReceptor activationRatsEnhanced locomotionDopamineGeneration of locomotionAMPHNAccSaline
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