2024
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
Huuki-Myers L, Spangler A, Eagles N, Montgomery K, Kwon S, Guo B, Grant-Peters M, Divecha H, Tippani M, Sriworarat C, Nguyen A, Ravichandran P, Tran M, Seyedian A, Hyde T, Kleinman J, Battle A, Page S, Ryten M, Hicks S, Martinowich K, Collado-Torres L, Maynard K, Akbarian S, Abyzov A, Ahituv N, Arasappan D, Almagro Armenteros J, Beliveau B, Bendl J, Berretta S, Bharadwaj R, Bhattacharya A, Bicks L, Brennand K, Capauto D, Champagne F, Chatterjee T, Chatzinakos C, Chen Y, Chen H, Cheng Y, Cheng L, Chess A, Chien J, Chu Z, Clarke D, Clement A, Collado-Torres L, Cooper G, Crawford G, Dai R, Daskalakis N, Davila-Velderrain J, Deep-Soboslay A, Deng C, DiPietro C, Dracheva S, Drusinsky S, Duan Z, Duong D, Dursun C, Eagles N, Edelstein J, Emani P, Fullard J, Galani K, Galeev T, Gandal M, Gaynor S, Gerstein M, Geschwind D, Girdhar K, Goes F, Greenleaf W, Grundman J, Guo H, Guo Q, Gupta C, Hadas Y, Hallmayer J, Han X, Haroutunian V, Hawken N, He C, Henry E, Hicks S, Ho M, Ho L, Hoffman G, Huang Y, Huuki-Myers L, Hwang A, Hyde T, Iatrou A, Inoue F, Jajoo A, Jensen M, Jiang L, Jin P, Jin T, Jops C, Jourdon A, Kawaguchi R, Kellis M, Kleinman J, Kleopoulos S, Kozlenkov A, Kriegstein A, Kundaje A, Kundu S, Lee C, Lee D, Li J, Li M, Lin X, Liu S, Liu J, Liu J, Liu C, Liu S, Lou S, Loupe J, Lu D, Ma S, Ma L, Margolis M, Mariani J, Martinowich K, Maynard K, Mazariegos S, Meng R, Myers R, Micallef C, Mikhailova T, Ming G, Mohammadi S, Monte E, Montgomery K, Moore J, Moran J, Mukamel E, Nairn A, Nemeroff C, Ni P, Norton S, Nowakowski T, Omberg L, Page S, Park S, Patowary A, Pattni R, Pertea G, Peters M, Phalke N, Pinto D, Pjanic M, Pochareddy S, Pollard K, Pollen A, Pratt H, Przytycki P, Purmann C, Qin Z, Qu P, Quintero D, Raj T, Rajagopalan A, Reach S, Reimonn T, Ressler K, Ross D, Roussos P, Rozowsky J, Ruth M, Ruzicka W, Sanders S, Schneider J, Scuderi S, Sebra R, Sestan N, Seyfried N, Shao Z, Shedd N, Shieh A, Shin J, Skarica M, Snijders C, Song H, State M, Stein J, Steyert M, Subburaju S, Sudhof T, Snyder M, Tao R, Therrien K, Tsai L, Urban A, Vaccarino F, van Bakel H, Vo D, Voloudakis G, Wamsley B, Wang T, Wang S, Wang D, Wang Y, Warrell J, Wei Y, Weimer A, Weinberger D, Wen C, Weng Z, Whalen S, White K, Willsey A, Won H, Wong W, Wu H, Wu F, Wuchty S, Wylie D, Xu S, Yap C, Zeng B, Zhang P, Zhang C, Zhang B, Zhang J, Zhang Y, Zhou X, Ziffra R, Zeier Z, Zintel T. A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex. Science 2024, 384: eadh1938. PMID: 38781370, PMCID: PMC11398705, DOI: 10.1126/science.adh1938.Peer-Reviewed Original ResearchConceptsRNA sequencing dataCell type compositionGene expression platformSpatial transcriptomics technologiesAnterior-posterior axisCell-cell interactionsTranscriptome mapExpression platformHuman dorsolateral prefrontal cortexTranscriptomic technologiesSingle-cellCell typesPrefrontal cortexMolecular organizationDorsolateral prefrontal cortexHuman prefrontal cortex
2020
Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex
Glausier J, Datta D, Fish K, Chung D, Melchitzky D, Lewis D. Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex. Neuroscience 2020, 452: 181-191. PMID: 33212224, PMCID: PMC7770119, DOI: 10.1016/j.neuroscience.2020.10.022.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsDorsolateral prefrontal cortexHuman dorsolateral prefrontal cortexPyramidal neuronsDendritic spinesDensity of spinesMonkey dorsolateral prefrontal cortexPrefrontal cortexPrimate dorsolateral prefrontal cortexDeep cortical layersPyramidal neuron activitySpecific neural circuitsGABAergic inputsGlutamatergic inputsGABAergic interneuronsGlutamatergic synapsesLaminar differencesCore cognitive functionNeuron activitySynaptic informationNeuron synapseCortical layersInterneuronsRecurrent excitationCognitive function
2019
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells
Duarte RRR, Bachtel ND, Côtel MC, Lee SH, Selvackadunco S, Watson IA, Hovsepian GA, Troakes C, Breen GD, Nixon DF, Murray RM, Bray NJ, Eleftherianos I, Vernon AC, Powell TR, Srivastava DP. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Biological Psychiatry 2019, 86: 120-130. PMID: 31097295, PMCID: PMC6614717, DOI: 10.1016/j.biopsych.2019.03.977.Peer-Reviewed Original ResearchConceptsHuman neural progenitor cellsProtein translationNeural progenitor cellsMotility behaviorAvailable expression dataRibosomal protein S6Protein Kinase SignalingRegulation of AMPKProgenitor cellsNutrient sensing mechanismsProtein kinase alphaQuantitative polymerase chain reactionPsychiatric risk allelesDrosophila melanogasterTranscriptional changesKinase signalingProtein S6Transcriptomic profilingRNA interferenceNeural stem cellsExpression changesKinase alphaUnknown roleExpression dataHuman dorsolateral prefrontal cortex
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply