2024
Configuration of electrical synapses filters sensory information to drive behavioral choices
Almoril-Porras A, Calvo A, Niu L, Beagan J, Díaz García M, Hawk J, Aljobeh A, Wisdom E, Ren I, Wang Z, Colón-Ramos D. Configuration of electrical synapses filters sensory information to drive behavioral choices. Cell 2024, 188: 89-103.e13. PMID: 39742807, DOI: 10.1016/j.cell.2024.11.037.Peer-Reviewed Original ResearchConceptsElectrical synapsesSensory informationGap junction proteinBehavioral strategiesReduced membrane capacitanceProcessing of sensory informationIncreased membrane resistanceSensory information processingAbnormal responseJunction proteinsSynaptic configurationsInnexin 1Process sensory informationC. elegansBehavioral responsesBehavioral choicesMigratory behaviorSensory stimuliThermotaxis behaviorInformation processingInterneuronsChemical synapsesSynapsesBrain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12: rp91722. PMID: 39556415, PMCID: PMC11573349, DOI: 10.7554/elife.91722.Peer-Reviewed Original ResearchConceptsHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliBrain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12 DOI: 10.7554/elife.91722.4.Peer-Reviewed Original ResearchHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliAssessing Pediatric Cognitive Development via Multisensory Brain Imaging Analysis
Belyaeva I, Wang Y, Wilson T, Calhoun V, Stephen J, Adali T. Assessing Pediatric Cognitive Development via Multisensory Brain Imaging Analysis. 2015 23rd European Signal Processing Conference (EUSIPCO) 2024, 1362-1366. DOI: 10.23919/eusipco63174.2024.10714926.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional magnetic resonance imaging dataMultisensory integrationSensory stimuliEffect of multisensory integrationMultisensory integration effectsMultiple sensory stimuliBrain imaging modalitiesCognitive developmentBrain image analysisBrain developmental patternsSensory modalitiesBrain componentsLearning paradigmMagnetoencephalographyMagnetic resonance imagingBrainDevelopmental patternsStimuliMultiple sensesCanonical polyadic tensor decompositionMultimodal data fusion frameworkAdolescentsMultitask learning paradigmPolyadic tensor decomposition
2023
Reflections on Cross-Modal Correspondences: Current Understanding and Issues for Future Research
Motoki K, Marks L, Velasco C. Reflections on Cross-Modal Correspondences: Current Understanding and Issues for Future Research. Multisensory Research 2023, 37: 1-23. PMID: 37963487, DOI: 10.1163/22134808-bja10114.Peer-Reviewed Original ResearchCross-modal correspondencesFuture researchBehavioral measuresSensory featuresSensory stimuliSensory dimensionsExplosion of researchExplanatory frameworkRelative associationComplementary perspectivesMost peopleNarrative reviewResearchStimuliSensesAssociationMultiple fieldsDimensionsDifferent kindsCorrespondencePeopleMeasuresViewPerspectiveResearchersSpatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
2022
Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations
Sanganahalli BG, Thompson GJ, Parent M, Verhagen JV, Blumenfeld H, Herman P, Hyder F. Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations. PLOS ONE 2022, 17: e0267916. PMID: 35522646, PMCID: PMC9075615, DOI: 10.1371/journal.pone.0267916.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusVentral posterior medialVentral posterior lateralThalamic activationFunctional MRIPosterior medial thalamic nucleusMedial thalamic nucleiSensory stimuliLateral geniculate nucleusPost-mortem humanOlfactory stimuliHigh-field functional MRIField functional MRIWhisker stimuliDeep brain regionsRat thalamusThalamic nucleiGeniculate nucleusMediodorsal nucleusRat brainInferior colliculusThalamusDifferent sensory stimuliCortical activationCortical activity
2020
Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma
Kaye AP, Krystal JH. Predictive Processing in Mental Illness: Hierarchical Circuitry for Perception and Trauma. Journal Of Psychopathology And Clinical Science 2020, 129: 629-632. PMID: 32757606, DOI: 10.1037/abn0000628.Peer-Reviewed Original ResearchConceptsTrauma-related disordersPredictive processingDisorders of perceptionNeural circuitsHigher-order predictionsAbnormal psychologyPrediction errorSensory stimuliPredictive codingHierarchical circuitryPrior beliefsNew sensory dataPerceptionBayesian processPsychiatric disordersPsychotic disordersHierarchical viewHierarchical organizationMental illnessSensory dataBeliefsDisordersFuture directionsComputational layerProcessingCo-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Sakellariou D, Nesbitt AD, Higgins S, Beniczky S, Rosenzweig J, Drakatos P, Gildeh N, Murphy PB, Kent B, Williams AJ, Kryger M, Goadsby PJ, Leschziner GD, Rosenzweig I. Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome. Cephalalgia 2020, 40: 949-958. PMID: 32276548, PMCID: PMC7412948, DOI: 10.1177/0333102420902705.Peer-Reviewed Original ResearchConceptsHead syndromeRetrospective case-control studyPotential underlying pathophysiologyWhole-night EEGsSleep/wake periodsSleep disorders clinicCase-control studyWake-sleep statesExternal sensory stimuliElectroencephalographic biomarkerPatients' qualityUnderlying pathophysiologyDisorders ClinicSleep-wake transitionsPolysomnographic recordingsSyndromeAlpha-band oscillationsPatientsOscillatory activityWake periodAlpha rhythmSensory stimuliBand oscillationsLoud noisePreliminary findings
2019
Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance
Neske G, Nestvogel D, Steffan P, McCormick D. Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance. Journal Of Neuroscience 2019, 39: 10044-10059. PMID: 31672787, PMCID: PMC6978938, DOI: 10.1523/jneurosci.1226-18.2019.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexSensory processingVisual detection performanceCortical neuronal responsesCortical sensory processingWhole-cell recordingsMouse visual systemSensory cortical activityNeuronal membrane potentialArousal levelNeuronal responsivenessFunction of arousalMice increasesNeuronal responsesCortical activityV1 responsesVisual detection taskCortexSensory stimuliSensory responsesLocomotion periodsVisual stimuliBehavioral performanceMembrane potentialModulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal Of Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Mental Retardation ProteinFragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesPyridinesShaw Potassium ChannelsConceptsAuditory brainstem responseWild-type animalsRepetitive firingABR wave ICurrent-clamp recordingsAuditory brainstem nucleiVoltage-clamp recordingsHigh-frequency firingSingle action potentialFragile X syndromeTrapezoid bodyBrainstem nucleiBrainstem responseMedial nucleusAuditory brainstemAuditory nerveWave IWave IVAction potentialsSensory stimuliKv3.1 channelsCentral processingMental retardation proteinHigh sound levelsMice
2016
Epicenters of dynamic connectivity in the adaptation of the ventral visual system
Prčkovska V, Huijbers W, Schultz A, Ortiz‐Teran L, Peña‐Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping 2016, 38: 1965-1976. PMID: 28029725, PMCID: PMC5342908, DOI: 10.1002/hbm.23497.Peer-Reviewed Original ResearchConceptsFunctional connectivityReorganization of functional connectivityVentral visual systemDynamic functional connectivityCognitive processing areasRepetition paradigmBrain systemsRepetition-suppressionAssociation cortexSynchrony changesConnectivity changesGraph theory methodsPrimary visual areaSensory stimuliConnectivity reorganizationVisual areasNeuronal responsesProcessing areasCortexDistant connectionsEnhanced synchronyBrain
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchConceptsBrain responsesHigher Body Mass IndexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patternsCompeting Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activitiesKetamine-Induced Hallucinations
Powers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations. Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPerceptual inputVerbal hallucinationsPredictive coding modelDelusion-like ideasPerceptual disruptionsPerceptual expectationsPerceptual environmentCoding modelPhenomenological experienceSensory stimuliStimulation environmentAuditory hallucinationsHealthy participantsHallmark symptomFirst-episode psychosisMusical hallucinationsMRI scannerHallucinationsParticipantsMagnetic resonance imaging (MRI) scannerPsychosisAmotivationPerceptVivid hallucinations
2014
Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli
McCormick C, Hessl D, Macari SL, Ozonoff S, Green C, Rogers SJ. Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli. Autism Research 2014, 7: 468-480. PMID: 24788961, PMCID: PMC6960008, DOI: 10.1002/aur.1382.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSensory symptomsRepetitive behaviorsParents of childrenTypical developmentElectrodermal activityRepetitive stimuliSensory stimuliYoung childrenSympathetic nervous system arousalAbnormal responseReport higher levelsEDA dataStandardized questionnaireSymptomsPhysiological arousalTD groupParent reportSpectrum disorderGroup differencesHypothesized relationshipsChildrenBehavioral profileArousalStimuliCortical oscillations arise from contextual interactions that regulate sparse coding
Jadi MP, Sejnowski TJ. Cortical oscillations arise from contextual interactions that regulate sparse coding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6780-6785. PMID: 24742427, PMCID: PMC4020078, DOI: 10.1073/pnas.1405300111.Peer-Reviewed Original ResearchConceptsInhibitory neuronsFiring ratePower of oscillationsMonosynaptic inputDisynaptic pathwayHigher firing ratesLow firing ratesDisynaptic inputCortical circuitsSynaptic plasticityCortical stateCortical oscillationsModel cortical circuitSensory stimuliBehavioral statesStimulationSensory inputComplex natural stimuliInhibitory controlCortexNeuronsSpike timingActivity balanceNatural stimuliParadoxical experimental findingsClinical features of Tourette syndrome and tic disorders
Leckman JF, King RA, Bloch MH. Clinical features of Tourette syndrome and tic disorders. Journal Of Obsessive-Compulsive And Related Disorders 2014, 3: 372-379. PMID: 30197854, PMCID: PMC6124690, DOI: 10.1016/j.jocrd.2014.03.004.Peer-Reviewed Original ResearchTourette syndromeTic disordersLong-term clinical courseLong-term outcomesAge 10 yearsAttention deficit hyperactivity disorderCo-occurring conditionsClinical courseClinical featuresObsessive-compulsive disorderTic symptomsVisual-motor integrationVocal ticsPsychosocial stressMost childrenCourse of monthsLiterature searchRelevant articlesMotor integrationStereotyped movementsHyperactivity disorderEarly adulthoodDisordersNeurodevelopmental disordersSensory stimuli
2013
The role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents
Witt ST, Stevens MC. The role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents. Brain Imaging And Behavior 2013, 7: 260-273. PMID: 23475755, PMCID: PMC3743949, DOI: 10.1007/s11682-013-9224-5.Peer-Reviewed Original ResearchConceptsPrefrontal cortexLow-level sensorySignificant maturational effectsVentrolateral prefrontal cortexDynamic causal modelingInternal clock mechanismFinger-tapping taskCognitive controlSensorimotor timingBehavioral accuracyAuditory cuesTiming taskFMRI studyBaseline connectivitySensory regionsCognitive functionDCM studySensory stimuliCausal modelingAuditory cortexMotor regionsCuesBrain regionsAccurate performanceMotor control
2011
Case Series: Sensory Intolerance as a Primary Symptom of Pediatric OCD
Hazen E, Reichert E, Piacentini J, Miguel E, do Rosario M, Pauls D, Geller D. Case Series: Sensory Intolerance as a Primary Symptom of Pediatric OCD. 2011 DOI: 10.3109/10401230802437365.Peer-Reviewed Original Research
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