2024
Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data
Lochmann van Bennekom M, IntHout J, Gijsman H, Akdede B, Yağcıoğlu A, Barnes T, Galling B, Gueorguieva R, Kasper S, Kreinin A, Nielsen J, Nielsen R, Remington G, Repo-Tiihonen E, Schmidt-Kraepelin C, Shafti S, Xiao L, Correll C, Verkes R. Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data. Schizophrenia Research 2024, 272: 1-11. PMID: 39142215, DOI: 10.1016/j.schres.2024.07.035.Peer-Reviewed Original ResearchClinical Global Impression ScaleSchizophrenia spectrum disordersPositive and Negative Syndrome ScaleBaseline PANSS total scoreAntipsychotic polypharmacyPANSS total scoreTotal scorePositive symptomsPsychotic patientsPositive and Negative Syndrome Scale positive symptom subscaleNegative symptom subscale scoreSubgroup of psychotic patientsBaseline positive symptomsExtrapyramidal side effectsNegative Syndrome ScalePositive symptom subscaleSecond-generation antipsychoticsGlobal Impression ScaleModerators of efficacySeverely psychotic patientsStudy-level moderatorsStudy discontinuationSymptom subscale scoresAntipsychotic monotherapySyndrome ScaleSubgroup Identification Through Multiplex Community Structure Within Functional Connectivity Networks
Yang H, Ortiz-Bouza M, Vu T, Laport F, Calhoun V, Aviyente S, Adali T. Subgroup Identification Through Multiplex Community Structure Within Functional Connectivity Networks. 2024, 00: 2141-2145. DOI: 10.1109/icassp48485.2024.10446076.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional networksResting-state fMRI dataMultiplex networksMulti-subject functional magnetic resonance imagingNature of psychiatric disordersFunctional connectivity networksDiagnostic heterogeneityPsychotic patientsIndividual functional networksPsychiatric disordersCommunity detectionGroup differencesFMRI dataData-driven methodMultiple networksConnectivity networksMagnetic resonance imagingIdentified subgroupsNetworkSubgroup identificationResonance imagingSubject correlationSubgroup structure
2023
Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms
Oliva H, Monteiro-Junior R, Oliva I, Powers A. Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 125: 110771. PMID: 37075881, DOI: 10.1016/j.pnpbp.2023.110771.Peer-Reviewed Original ResearchConceptsExercise interventionGeneral symptomsPsychotic symptomsEfficacy of exerciseEffects of exerciseSpecific brain areasWeb of ScienceCochrane CENTRALSymptom improvementTemporal lobeBrain areasLarge effect sizesPsychotic patientsPositive symptomsNegative symptomsSymptomsNeurobiological mechanismsNeurophysiology studiesInterventionExerciseEffect sizeDatabase searchSignificant improvementNeurobiological modelsPatients
2015
Patients with Psychotic Disorders in Solid-Organ Transplant
Zimbrean P, Emre S. Patients with Psychotic Disorders in Solid-Organ Transplant. Progress In Transplantation 2015, 25: 289-296. PMID: 26645920, DOI: 10.7182/pit2015296.Peer-Reviewed Original ResearchConceptsPsychotic disordersOrgan transplantsTransplant candidatesComorbid conditionsMedical comorbid conditionsOutcomes of patientsType of transplantAssociated comorbid conditionsNumber of hospitalizationsSeverity of psychosisToxic effectsPosttransplant variablesTransplant recipientsAbsolute contraindicationClinical courseOrgan failureMedication adherenceOrgan recipientsPsychiatric hospitalizationPsychotic episodeWaiting listPatientsPsychotic patientsTransplantDescriptive study
2003
Discontinuation of Antidepressants in Newly Admitted Psychotic Patients
Bowers MB, McKay BG, Mazure CM. Discontinuation of Antidepressants in Newly Admitted Psychotic Patients. Journal Of Neuropsychiatry 2003, 15: 227-230. PMID: 12724466, DOI: 10.1176/jnp.15.2.227.Peer-Reviewed Original Research
1996
Day hospital/crisis respite care versus inpatient care, Part II: Service utilization and costs
Sledge W, Tebes J, Wolff N, Helminiak T. Day hospital/crisis respite care versus inpatient care, Part II: Service utilization and costs. American Journal Of Psychiatry 1996, 153: 1074-1083. PMID: 8678177, DOI: 10.1176/ajp.153.8.1074.Peer-Reviewed Original ResearchConceptsCommunity mental health centerService utilizationEffective acute careMental health centersIll psychiatric patientsTotal direct costsSignificant differencesService utilization profilesIndex episodeAcute carePatient groupInpatient hospitalizationInpatient careHealth centersInpatient programDay hospitalNonpsychotic patientsOutpatient servicesAverage stayDual diagnosisPatientsPsychiatric patientsRespite careAffective disordersPsychotic patientsPreliminary evidence of an association between sensorimotor gating and distractibility in psychosis
Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. Journal Of Neuropsychiatry 1996, 8: 60-66. PMID: 8845703, DOI: 10.1176/jnp.8.1.60.Peer-Reviewed Original ResearchConceptsSensory gatingChronic psychotic patientsAcoustic startle reflexLateralized attentionImpaired sensory gatingPosner testSensorimotor gatingPsychotic patientsContinuous Performance TestStartle reflexInformation-processing deficitsDistractibility tasksPreliminary evidenceDistractibilityTask scores
1995
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scanAssessment of extrapyramidal symptoms during acute neuroleptic treatment.
Mazure CM, Cellar JS, Bowers MB, Nelson JC, Takeshita J, Zigun B. Assessment of extrapyramidal symptoms during acute neuroleptic treatment. The Journal Of Clinical Psychiatry 1995, 56: 94-100. PMID: 7883736.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAkathisia, Drug-InducedAntipsychotic AgentsBasal Ganglia DiseasesDystoniaFemaleHumansMaleMiddle AgedParkinson Disease, SecondaryPhysical ExaminationPsychiatric Status Rating ScalesPsychotic DisordersReproducibility of ResultsSeverity of Illness IndexStatistics, NonparametricConceptsExtrapyramidal symptomsDrug regimenAcute treatmentNeuroleptic drugsSide effectsInterrater reliabilityAcute neuroleptic treatmentPatient's drug regimenExtrapyramidal Symptoms ScaleExtrapyramidal side effectsTraditional neuroleptic drugsLow nonsignificant correlationsRatings of symptomsAcute administrationNeuroleptic treatmentAdverse reactionsParkinson's diseasePsychotic symptomsSymptom ScalePsychotic patientsEPS scaleSymptomsClinician ratersCliniciansInterrater agreement
1992
The Assessment of Insight in Psychosis
David A, Buchanan A, Reed A, Almeida O. The Assessment of Insight in Psychosis. The British Journal Of Psychiatry 1992, 161: 599-602. PMID: 1422606, DOI: 10.1192/bjp.161.5.599.Peer-Reviewed Original ResearchValproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol
Mazure CM, Druss BG, Cellar JS. Valproate Treatment of Older Psychotic Patients with Organic Mental Syndromes and Behavioral Dyscontrol. Journal Of The American Geriatrics Society 1992, 40: 914-916. PMID: 1512389, DOI: 10.1111/j.1532-5415.1992.tb01990.x.Peer-Reviewed Original Research
1991
Cerebral laterality, symptoms, and diagnosis in psychotic patients
Wexler B, Giller E, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry 1991, 29: 103-116. PMID: 1995082, DOI: 10.1016/0006-3223(91)90039-o.Peer-Reviewed Original ResearchConceptsRight ear advantageLower right-ear advantagesManic patientsPositive symptomsNegative symptomsCerebral lateralitySubset of patientsDisease-related decreaseWord TestSchizoaffective patientsSymptomatic inpatientsDepressed patientsHealthy controlsSymptom remissionSchizophrenic patientsMood disturbancePatientsMore symptomsPsychotic patientsSymptomsDichotic word testLeft hemisphereEar advantageThought disorderSimilar changes
1988
A Preference for Activity
Cole M, Greene L. A Preference for Activity. Occupational Therapy In Mental Health 1988, 8: 53-67. DOI: 10.1300/j004v08n03_04.Peer-Reviewed Original Research
1987
Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?
Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? Psychopharmacology Series 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.Peer-Reviewed Original ResearchConceptsMost psychotic patientsDA receptor blockerTreatment of choiceDopamine neuron activityCentral catecholamine systemsReceptor blockadeReceptor blockersCatecholamine neuronsNeuroleptic effectsMajor symptomsAntipsychotic drugsCatecholamine systemsAntipsychotic propertiesForebrain regionsNeuronal activityCatecholamine receptorsSide effectsDopamine systemNeuron activityPsychotic patientsTherapeutic efficacyMode of actionFeedback pathwaysTreatmentNeuroleptics
1982
The training psychotherapist in a therapeutic community
Bell M. The training psychotherapist in a therapeutic community. Psychotherapy 1982, 19: 26-30. DOI: 10.1037/h0088412.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply