2022
Using NeuroPAL Multicolor Fluorescence Labeling to Identify Neurons in C. elegans
Santiago E, Shelar A, Christie N, Lewis‐Hayre M, Koelle M. Using NeuroPAL Multicolor Fluorescence Labeling to Identify Neurons in C. elegans. Current Protocols 2022, 2: e610. PMID: 36521003, PMCID: PMC10257892, DOI: 10.1002/cpz1.610.Peer-Reviewed Original Research
2016
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality
Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, Ralevski A, Horvath TL, Iwasaki A. Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. Cell Host & Microbe 2016, 19: 788-799. PMID: 27281569, PMCID: PMC4902295, DOI: 10.1016/j.chom.2016.05.008.Peer-Reviewed Original ResearchConceptsGenital HSV-1 infectionEnteric nervous systemHSV-1 infectionSensory nervous systemNervous systemGenital herpesToxic megacolonHSV-1Genital mucosal epithelial cellsPeripheral sensory nervous systemDorsal root gangliaPathological inflammatory responsesMucosal epithelial cellsHerpes simplex virus 1Simplex virus 1Urinary retentionEnteric neuronsLaxative treatmentAutonomic gangliaRoot gangliaInflammatory responseViral gene transcriptionMouse modelInfectionEpithelial cellsSensory Neurons that Detect Stretch and Nutrients in the Digestive System
Williams E, Chang R, Strochlic D, Umans B, Lowell B, Liberles S. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell 2016, 166: 209-221. PMID: 27238020, PMCID: PMC4930427, DOI: 10.1016/j.cell.2016.05.011.Peer-Reviewed Original ResearchConceptsSensory neuronsNormal autonomic functionVagal sensory neuronsGut hormone responsesGut-to-brainVagal afferentsGut hormonesNeuronal identityPeripheral anatomyVagus nerveAutonomic functionConduction velocityMechanical distensionOrgan distensionAnatomical mappingGastrointestinal physiologyHomeostatic responseHormonal responsesNeuronsGastrointestinal tractCentral anatomyNeural inputBody-brain connectionIngested nutrientsDistension
2015
Intravenous Preload of Mesenchymal Stem Cells Rescues Erectile Function in a Rat Model of Cavernous Nerve Injury
Takayanagi A, Sasaki M, Kataoka-Sasaki Y, Kobayashi K, Matsuda Y, Oka S, Masumori N, Kocsis JD, Honmou O. Intravenous Preload of Mesenchymal Stem Cells Rescues Erectile Function in a Rat Model of Cavernous Nerve Injury. The Journal Of Sexual Medicine 2015, 12: 1713-1721. PMID: 26211660, DOI: 10.1111/jsm.12957.Peer-Reviewed Original ResearchConceptsMajor pelvic ganglionGlia cell-derived neurotrophic factorArterial pressureCN injuryErectile dysfunctionIntracavernous pressureMesenchymal stem cellsMSC groupErectile functionDMEM groupNeurotrophic factorCavernous nerve injury modelMale Sprague-Dawley ratsNerve injury modelPotential preventive effectMale SD ratsImportant neurotrophic factorSprague-Dawley ratsReal-time quantitative real-time polymerase chain reactionExpression levelsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionMRNA expression levelsPelvic gangliaPolymerase chain reaction
2014
Sensory determinants of behavioral dynamics in Drosophila thermotaxis
Klein M, Afonso B, Vonner AJ, Hernandez-Nunez L, Berck M, Tabone CJ, Kane EA, Pieribone VA, Nitabach MN, Cardona A, Zlatic M, Sprecher SG, Gershow M, Garrity PA, Samuel AD. Sensory determinants of behavioral dynamics in Drosophila thermotaxis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 112: e220-e229. PMID: 25550513, PMCID: PMC4299240, DOI: 10.1073/pnas.1416212112.Peer-Reviewed Original Research
2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
1993
The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances
Fisher T, Lin C, Kaczmarek L. The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances. Journal Of Neurophysiology 1993, 69: 2164-2173. PMID: 7688803, DOI: 10.1152/jn.1993.69.6.2164.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalcium ChannelsCells, CulturedChloride ChannelsElectric StimulationElectrophysiologyFMRFamideGangliaImmunohistochemistryIon ChannelsMembrane PotentialsMembrane ProteinsNeuritesNeuronsNeuropeptidesNeurotransmitter AgentsPotassium ChannelsStereotyped BehaviorTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsAction potentialsElectrical stimulationVoltage-activated calcium currentsOnset of afterdischargePowerful inhibitory influenceIntact abdominal gangliaIon substitution experimentsVoltage-clamp experimentsAfferent nervesProtein kinase C. 5Channel blockersCalcium currentPrimary cell culturesAbdominal ganglionInhibitory influenceAfterdischargesCyclic AMP analogueFMRFaOutward currentsNeuronal processesNeuronsAplysia bag cell neuronsReversal potential
1992
Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7
Loechner K, Mattessich-Arrandale J, Azhderian E, Kaczmarek L. Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7. Brain Research 1992, 581: 315-318. PMID: 1393536, DOI: 10.1016/0006-8993(92)90724-n.Peer-Reviewed Original ResearchHerpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs
Landry M, Bull C. Herpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs. Intervirology 1992, 33: 204-210. PMID: 1326498, DOI: 10.1159/000150252.Peer-Reviewed Original Research
1989
Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex
Zecevic D, Wu J, Cohen L, London J, Hopp H, Falk C. Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. Journal Of Neuroscience 1989, 9: 3681-3689. PMID: 2795148, PMCID: PMC6569909, DOI: 10.1523/jneurosci.09-10-03681.1989.Peer-Reviewed Original ResearchOptical Measurement of Action Potential Activity in Invertebrate Ganglia
Cohen L, Hopp H, Wu J, Xiao C, London J, Zecevic D. Optical Measurement of Action Potential Activity in Invertebrate Ganglia. Annual Review Of Physiology 1989, 51: 527-541. PMID: 2653195, DOI: 10.1146/annurev.ph.51.030189.002523.Peer-Reviewed Original ResearchConceptsAplysia abdominal ganglionGill withdrawal reflexBuccal gangliaAbdominal ganglionAction potential activitySynaptic potentialsGill withdrawalSpike activityGangliaNeuronal basisNeuronsInvertebrate gangliaBehaving animalsReflexNetwork of cellsPotential activityFeedingOptical measurementsActivityInhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia
Conn P, Strong J, Kaczmarek L. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. Journal Of Neuroscience 1989, 9: 480-487. PMID: 2918372, PMCID: PMC6569798, DOI: 10.1523/jneurosci.09-02-00480.1989.Peer-Reviewed Original Research
1988
Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type
Landry M, Zibello T. Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type. The Journal Of Infectious Diseases 1988, 158: 1220-1226. PMID: 2848899, DOI: 10.1093/infdis/158.6.1220.Peer-Reviewed Original ResearchConceptsHerpes simplex virus type 1Simplex virus type 1Virus type 1Clinical diseaseHSV typesSuperinfecting virusType 1Heterologous virus typesPrevious genital infectionsLevels of serumHSV antibodiesGenital infectionHSV-2Prior infectionLatent infectionHSV-1Type 2Months postinoculationGuinea pigsVirus typeInitial virusLatent virusSuperinfectionInfectionDiseaseOptical monitoring of activity of many neurons in invertebrate ganglia during behaviors
Wu J, London JA, Zecevic D, Höpp H, Cohen LB, Xiao C. Optical monitoring of activity of many neurons in invertebrate ganglia during behaviors. Cellular And Molecular Life Sciences 1988, 44: 369-376. PMID: 3286282, DOI: 10.1007/bf01940529.Peer-Reviewed Original Research
1987
Alpha bag cell peptide directly modulates the excitability of the neurons that release it
Kauer J, Fisher T, Kaczmarek L. Alpha bag cell peptide directly modulates the excitability of the neurons that release it. Journal Of Neuroscience 1987, 7: 3623-3632. PMID: 2824716, PMCID: PMC6569037, DOI: 10.1523/jneurosci.07-11-03623.1987.Peer-Reviewed Original ResearchConceptsAlpha-bag cell peptideBag cell neuronsAlpha-BCPCell neuronsBag cell peptidesPotassium currentCell peptidesVoltage-dependent potassium currentsCAMP levelsVoltage-dependent outward currentIntact abdominal gangliaBag cell clustersAdenylate cyclase activator forskolinAbility of forskolinCyclase activator forskolinLevels of cAMPVoltage-clamp experimentsElectrophysiological actionsIntracellular cAMP levelsImmunohistochemical stainingIntact gangliaAbdominal ganglionPhosphodiesterase inhibitorPharmacological elevationOutward currents
1986
Chapter 7 The role of protein kinases in the control of prolonged changes in neuronal excitability
Kaczmarek L, Strong J, Kauer J. Chapter 7 The role of protein kinases in the control of prolonged changes in neuronal excitability. Progress In Brain Research 1986, 69: 77-90. PMID: 3328878, DOI: 10.1016/s0079-6123(08)61050-x.ChaptersSimultaneous monitoring of activity of many neurons from invertebrate ganglia using a multielement detecting system.
London JA, Zećevic D, Cohen LB. Simultaneous monitoring of activity of many neurons from invertebrate ganglia using a multielement detecting system. Society Of General Physiologists Series 1986, 40: 115-31. PMID: 3715522.Peer-Reviewed Original Research
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeuronsTwo Introns Define Functional Domains of a Neuropeptide Precursor in Aplysia1
Taussig R, Picciotto M, Scheller R. Two Introns Define Functional Domains of a Neuropeptide Precursor in Aplysia1. Clinical And Experimental Hypertension 1984, 6: 2133-2140. PMID: 6532597, DOI: 10.3109/10641968409046142.Peer-Reviewed Original Research
1982
An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysia
Kaczmarek L, Jennings K, Strumwasser F. An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysia. Brain Research 1982, 238: 105-115. PMID: 6282390, DOI: 10.1016/0006-8993(82)90774-0.Peer-Reviewed Original Research
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