2011
Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model
Wolff EF, Gao X, Yao KV, Andrews ZB, Du H, Elsworth JD, Taylor HS. Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model. Journal Of Cellular And Molecular Medicine 2011, 15: 747-755. PMID: 20406327, PMCID: PMC2998585, DOI: 10.1111/j.1582-4934.2010.01068.x.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopaminergic neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDopamine metabolite concentrationsPD mouse modelStem cell transplantationDisease modelsSite of lesionParkinson's disease modelPyramidal cell bodiesPatch-clamp recordingsMesenchymal stem-like cellsAllogenic stem cellsStem cellsStem-like cellsCell transplantationStriatal dopamineNeural markers nestinCentral neuronsDopaminergic cellsDendritic projectionsDopamine synthesisDopamine productionMouse model
2008
Human Endometrial Stem Cells Transplantation in a Parkinson's Disease Mouse Model.
Wolff E, Gao X, Andrews Z, Yao K, Du H, Taylor H. Human Endometrial Stem Cells Transplantation in a Parkinson's Disease Mouse Model. Biology Of Reproduction 2008, 78: 120-120. DOI: 10.1093/biolreprod/78.s1.120d.Peer-Reviewed Original ResearchDisease mouse modelParkinson's disease mouse modelTyrosine hydroxylaseNestin antibodyStriatal dopamineDopaminergic cellsDopaminergic pathwaysMouse modelMouse brainTherapeutic potentialNeurogenic differentiationWhole-cell patch-clamp recordingsCell patch-clamp recordingsPotassium channelsReproductive-aged womenStem cell transplantationBarium-sensitive potassium channelsDOPAC/dopamineDisease modelsNOD-SCID miceSensitive potassium channelsStem cellsParkinson's disease modelPyramidal cell bodiesPatch-clamp recordings
2007
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132
Zafar K, Inayat‐Hussain S, Ross D. A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. Journal Of Neurochemistry 2007, 102: 913-921. PMID: 17504267, DOI: 10.1111/j.1471-4159.2007.04637.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsApoptosisCaspasesCell Line, TransformedCysteine Proteinase InhibitorsDopamineDose-Response Relationship, DrugEnzyme ActivationLeupeptinsMesencephalonNerve DegenerationNeuronsOxidative StressParkinson DiseaseProteasome Endopeptidase ComplexRatsReactive Oxygen SpeciesSubstantia NigraConceptsN-acetylcysteineN27 cellsParkinson's diseaseProteasomal inhibitionAbility of dopamineCell deathCaspase-9Dopaminergic neuronsDopaminergic cellsMesencephalic cellsDA treatmentConcentration-dependent apoptosisMG132-induced apoptosisCaspase-dependent apoptosisDiseaseSelective lossMitochondrial membrane potential lossReactive oxygen speciesDopamineCaspase-3Membrane potential lossApoptosisInhibitionQuinoid metabolitesCaspase-2
1987
Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sciences 1987, 40: 193-202. PMID: 3491946, DOI: 10.1016/0024-3205(87)90359-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraParkinsonian disabilityDA neuronsSymptomatic animalsMedial regionAsymptomatic animalsHVA/DA ratioLateral regionsDA concentrationPrimate substantia nigraDA histofluorescenceNigrostriatal pathwayTetrahydropyridine (MPTP) toxicityDopaminergic neuronsContralateral halfDA ratioDopaminergic cellsLipofuscin fluorescenceCell bodiesStriatumIndividual neuronsNeuronsDifferential responsivenessMarked lossDopamine
1981
Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons
Skirboll L, Grace A, Hommer D, Rehfeld J, Goldstein M, Hökfelt T, Bunney B. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 1981, 6: 2111-2124. PMID: 6120481, DOI: 10.1016/0306-4522(81)90002-6.Peer-Reviewed Original ResearchConceptsCholecystokinin-like peptidesVentral tegmental areaDopaminergic neuronsFiring rateSubstantia nigraTegmental areaDopaminergic cellsExtracellular single-unit recording techniquesMidbrain dopamine-containing neuronsSingle-unit recording techniquesDopamine-containing neuronsBrain dopaminergic systemDopamine-rich areasMidbrain dopamine neuronsDepolarization inactivationResponsive neuronsDopamine neuronsDopaminergic systemComparable dosesTyrosine hydroxylaseCholecystokininBursting activityNeuronsImmunocytochemical techniquesRecording techniques
1980
Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons
Grace A, Hommer D, Bunney B. Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons. Brain Research Bulletin 1980, 5: 105-109. DOI: 10.1016/0361-9230(80)90017-9.Peer-Reviewed Original ResearchDA cellsZona reticulataGABA agonistsInhibitory influenceDA cell firing rateDopamine receptor blocker haloperidolStriato-nigral pathwayNigral dopamine cellsCell firing rateReticulata neuronsStriatal influencesSubstantia nigraDopaminergic cellsDopamine cellsNoxious stimuliLow dosesFiring rateNeuronsInhibitory effectAgonistsCell rateCellsHaloperidolMuscimolDoses
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonistsDopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDoses
1976
d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway
Bunney B, Achajanian G. d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway. Science 1976, 192: 391-393. PMID: 1257777, DOI: 10.1126/science.1257777.Peer-Reviewed Original ResearchConceptsD-amphetamineDepressant effectDopaminergic cell activityIntravenous d-amphetamineCentral dopaminergic neuronsStriato-nigral pathwayNeuronal feedback loopMicroiontophoretic applicationDopaminergic neuronsDopaminergic cellsCell activitySignificant slowingFeedback pathwaysPrevious dataCellsLesionsPathwayNeurons
1973
CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.
AGHAJANIAN G, BUNNEY B. CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut. 1973, 643-648. DOI: 10.1016/b978-0-08-017922-3.50120-9.Peer-Reviewed Original ResearchDopaminergic neuronsNeurophysiological identificationCentral dopaminergic neuronsSubstantia nigraDopaminergic cellsReticular formationRat brainRed nucleusAction potentialsZR cellsFiring patternsNeuronsExtracellular action potentialsRegular rhythmChloral hydrateLonger durationBursting patternDrugsState of ConnecticutCellsResponseAnesthesiaDopaminergicHalothaneBrain
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