2025
Effects of Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: An Umbrella Review of Systematic Reviews
Park J, Park H, Yoon S, Kim Y, Shin J, Lee S. Effects of Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: An Umbrella Review of Systematic Reviews. Stroke 2025, 56: 1243-1252. PMID: 40115991, DOI: 10.1161/strokeaha.124.048183.Peer-Reviewed Original ResearchConceptsEffects of robot-assisted therapyStandardized mean differenceRobot-assisted therapyRandomized Controlled TrialsFugl-Meyer AssessmentUmbrella review of systematic reviewsReview of systematic reviewsStages of stroke recoveryActivities of daily livingUpper extremity stroke rehabilitationMeta-analysesHigh-frequency therapyClinically Important DifferenceUpper limb rehabilitationDuration of interventionHigh-quality trialsReviewed meta-analysesClinically important difference thresholdAdd-on to conventional therapyChronic strokeStatistically significant improvementStroke rehabilitationUmbrella reviewMuscle strengthDaily living
2024
Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients
Yamaki T, Oka S, Iyama S, Sasaki M, Onodera R, Kataoka-Sasaki Y, Namioka T, Namioka A, Nakazaki M, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Yamaguchi M, Fukino M, Takazawa T, Hayasaka M, Owaku T, Funakura M, Onodera S, Ito Y, Kobune M, Kato J, Ishiai S, Kocsis J, Odaki M, Iwadate Y, Kobayashi S, Honmou O. Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients. Interdisciplinary Neurosurgery 2024, 36: 101927. DOI: 10.1016/j.inat.2023.101927.Peer-Reviewed Original ResearchSevere brain injury patientsAutologous mesenchymal stem cellsBrain injury patientsIntravenous infusionMesenchymal stem cellsAdverse eventsInjury patientsInfused mesenchymal stem cellsHealth Stroke ScaleSerious adverse eventsFugl-Meyer AssessmentInitial case seriesBrain metabolic activityStem cellsMSC infusionStroke ScaleNeurological deteriorationBarthel IndexCase seriesCNS tumorsNeurological functionFunctional statusFunctional improvementChronic patientsPlacebo effect
2015
Long-term Effectiveness of Intensive Therapy in Chronic Stroke
Wu X, Guarino P, Lo AC, Peduzzi P, Wininger M. Long-term Effectiveness of Intensive Therapy in Chronic Stroke. Neurorehabilitation And Neural Repair 2015, 30: 583-590. PMID: 26450442, DOI: 10.1177/1545968315608448.Peer-Reviewed Original ResearchConceptsFugl-Meyer AssessmentIntensive therapyUsual careRobot-assisted therapySubgroup analysisClinical trialsSevere upper limb impairmentVeterans Affairs Medical CenterChronic stroke populationChronic stroke patientsPrimary outcome measureRecent clinical trialsUpper limb impairmentLong-term effectivenessLong-term improvementMultivariate mixed-effects modelWeeks posttherapyChronic strokeStroke populationStroke patientsMotor benefitComparison therapyConventional therapyMotor functionMedical Center
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