2025
Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease
Yang Y, Duan Y, Lang S, Fondevila M, Schöler D, Harberts A, Cabré N, Chen S, Shao Y, Vervier K, Miyamoto Y, Zhang X, Chu H, Yang L, Tan C, Eckmann L, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Stärkel P, Lawley T, Schnabl B. Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease. Cell Host & Microbe 2025, 33: 957-972.e6. PMID: 40441146, PMCID: PMC12162233, DOI: 10.1016/j.chom.2025.05.003.Peer-Reviewed Original ResearchConceptsEthanol-induced liver diseaseAlcohol-associated liver diseaseAlcohol-associated hepatitisLiver diseaseGenome of Escherichia coliE. coliMetagenomic sequencing of fecal samplesInternational cohort of patientsGenetic manipulation of bacteriaGnotobiotic mouse modelOutcomes of patientsManipulation of bacteriaCohort of patientsScavenger receptor MARCOGlobal health burdenVirulence factorsMetagenomic sequencingGut microbiotaGenetic manipulationDisease progressionMouse modelKupffer cellsKpsMBacterial spreadInternational cohort
2024
Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review
Besteman S, Bogaert D, Bont L, Mejias A, Ramilo O, Weinberger D, Dagan R. Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review. The Lancet Respiratory Medicine 2024, 12: 915-932. PMID: 38991585, DOI: 10.1016/s2213-2600(24)00148-6.Peer-Reviewed Original ResearchRespiratory syncytial virusChildhood respiratory infectionsRespiratory infectionsSyncytial virusStreptococcus pneumoniaeRespiratory syncytial virus vaccineLower respiratory tract infectionsRespiratory tract infectionsSystematic reviewGlobal health burdenYears of ageRSV hospitalisationTract infectionsPneumococcal vaccineSevere diseaseGlobal morbidityEpidemiological associationMonoclonal antibodiesPathogen-pathogen interactionsPneumococciInfectionHealth burdenPathogenesisHost modulationApproaches to disease preventionManagement of alcohol-associated liver disease and alcohol use disorder in liver transplant candidates and recipients: Challenges and opportunities
Sharma P, Shenoy A, Shroff H, Kwong A, Lim N, Pillai A, Devuni D, Haque L, Balliet W, Serper M. Management of alcohol-associated liver disease and alcohol use disorder in liver transplant candidates and recipients: Challenges and opportunities. Liver Transplantation 2024, 30: 848-861. PMID: 38471008, DOI: 10.1097/lvt.0000000000000362.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseAlcohol use disorderAUD careValue-based care modelsPrevalence of alcohol use disordersPost-LTLiver transplantationManagement of alcohol-associated liver diseasePost-transplant patient survivalLiver diseaseRisk of disease recurrenceUse disorderImprove patient outcomesPost-LT relapseCare modelSystemic barriersTherapy accessDigital healthUnmet needsLiver transplant candidatesAlcohol consumptionCenters of excellenceGlobal health burdenAddiction specialistsCare
2023
Diabetic Kidney Disease An Update
Gupta S, Dominguez M, Golestaneh L. Diabetic Kidney Disease An Update. 2023, 107: 689-705. PMID: 37258007, DOI: 10.1016/j.mcna.2023.03.004.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseKidney diseaseManagement of diabetic kidney diseaseEnd-stage kidney diseaseChronic kidney diseaseGlobal health burdenPrimary care settingMechanisms of diabetic kidney diseaseAggressive managementPublic health challengePathophysiological mechanismsDiabetic nephropathyEarly recognitionClinical trialsCare settingsTherapeutic interventionsHealth burdenHealth challengesDiseaseDiagnostic termsNephropathyUnited States
2022
Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC
Vadset T, Rajaram A, Hsiao C, Katungi M, Magombe J, Seruwu M, Nsubuga B, Vyas R, Tatz J, Playter K, Nalule E, Natukwatsa D, Wabukoma M, Perez L, Mulondo R, Queally J, Fenster A, Kulkarni A, Schiff S, Grant P, Kabachelor E, Warf B, Sutin J, Lin P. Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC. Metabolites 2022, 12: 78. PMID: 35050201, PMCID: PMC8781620, DOI: 10.3390/metabo12010078.Peer-Reviewed Original ResearchCerebral blood flowTreatment failureETV/CPCEarly treatment failureProspective study protocolCerebral tissue oxygenationProgression of hydrocephalusVentriculoperitoneal shunt placementLong-term outcomesEvidence-based guidelinesPost-operative careEndoscopic third ventriculostomyCerebral metabolic rateMulti-center trialChoroid plexus cauterizationGlobal health burdenCURE Children's HospitalYears of agePost-operative measurementsHydrocephalus outcomesNeurodevelopmental outcomesSurgical treatmentNeurodevelopmental assessmentShunt placementChildren's Hospital
2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant species
2020
Epidemiology and Risk Factors
Amin H, Schindler J. Epidemiology and Risk Factors. 2020, 49-55. DOI: 10.1007/978-3-030-52552-1_5.ChaptersRisk factorsStroke riskNon-modifiable risk factorsIndividual stroke riskSignificant global health burdenModifiable risk factorsGlobal health burdenPutative risk factorsStroke physiciansInsulin resistanceOutpatient settingHealth burdenFuture burdenStrokeBurdenRiskFactorsInternistsEpidemiologyPhysiciansTrials
2017
Predicting preterm birth: Cervical length and fetal fibronectin
Son M, Miller ES. Predicting preterm birth: Cervical length and fetal fibronectin. Seminars In Perinatology 2017, 41: 445-451. PMID: 28935263, PMCID: PMC6033518, DOI: 10.1053/j.semperi.2017.08.002.BooksConceptsSpontaneous preterm birthQualitative fetal fibronectinPreterm birthCervical lengthFetal fibronectinFetal fibronectin measurementPreterm labor symptomsSignificant global health burdenCervical length assessmentSpontaneous preterm deliveryGlobal health burdenCervical shorteningLabor symptomsNeonatal morbidityPreterm deliverySingleton gestationsAsymptomatic womenHealth burdenScreening modalityPotential screening modalitiesClinical utilityPrevention strategiesObstetric strategiesLength assessmentBirth
2016
Epidemiology and Risk Factors
Amin H, Schindler J. Epidemiology and Risk Factors. 2016, 37-42. DOI: 10.1007/978-3-319-39605-7_5.ChaptersRisk factorsStroke riskIndividual stroke riskSignificant global health burdenModifiable risk factorsNonmodifiable risk factorsGlobal health burdenPutative risk factorsStroke physiciansInsulin resistanceOutpatient settingHealth burdenFuture burdenStrokeBurdenRiskFactorsInternistsEpidemiologyPhysiciansTrials
2014
Air Quality in Lanzhou, a Major Industrial City in China: Characteristics of Air Pollution and Review of Existing Evidence from Air Pollution and Health Studies
Zhang Y, Li M, Bravo MA, Jin L, Nori-Sarma A, Xu Y, Guan D, Wang C, Chen M, Wang X, Tao W, Qiu W, Zhang Y, Bell ML. Air Quality in Lanzhou, a Major Industrial City in China: Characteristics of Air Pollution and Review of Existing Evidence from Air Pollution and Health Studies. Water, Air, & Soil Pollution 2014, 225: 2187. PMID: 25838615, PMCID: PMC4380132, DOI: 10.1007/s11270-014-2187-3.Peer-Reviewed Original ResearchGlobal health burdenSerious health consequencesFuture epidemiological studiesOutdoor air pollutionHealth burdenEpidemiological studiesHealth StudyHealth outcomesSystematic reviewHealth consequencesHigh air pollution levelsAir pollutionMonthsAir pollution levelsAerodynamic diameterHealthReviewUrban Chinese citiesHealth-based standardsLevelsStudyFindings
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