2025
The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized Controlled StudyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINEAntiseizure Medications in Poststroke Seizures
Misra S, Wang S, Quinn T, Dawson J, Zelano J, Tanaka T, Grotta J, Khan E, Beriwal N, Funaro M, Perla S, Dev P, Larsson D, Hussain T, Liebeskind D, Yasuda C, Altalib H, Zaveri H, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Scalzo F, Ihara M, Sunnerhagen K, Walters M, Zhao Y, Jette N, Kasner S, Kwan P, Mishra N. Antiseizure Medications in Poststroke Seizures. Neurology 2025, 104: e210231. PMID: 39808752, DOI: 10.1212/wnl.0000000000210231.Peer-Reviewed Original ResearchConceptsRisk of biasLow-certainty evidenceModerate to high certainty evidenceNon-randomized Studies of Interventions toolDrug discontinuation ratesCochrane risk of bias toolRisk of bias toolAntiseizure medicationsSeizure recurrenceHigh risk of biasAdverse eventsCertainty of evidenceHigh-certainty evidencePoststroke seizuresModerate-certainty evidenceMortality rateRandomized Controlled TrialsDiscontinuation ratesAntiseizure medication useRecommendations AssessmentCochrane riskBias toolElectronic databasesNon-randomized studiesAssociated with high mortality rates
2024
Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Ozment C, Alexander P, Chandler W, Emani S, Hyslop R, Monagle P, Muszynski J, Willems A, Gehred A, Lyman E, Steffen K, Thiagarajan R, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman M, Muszynski J. Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e14-e24. PMID: 38959356, PMCID: PMC11216399, DOI: 10.1097/pcc.0000000000003494.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationPediatric extracorporeal membrane oxygenationAnticoagulation monitoringRisk of biasConsensus statementMonitoring of pediatric patientsPrognosis Studies toolPractice statementsEvidence-based recommendationsStandardized data extraction formCochrane risk of biasPediatric patientsMembrane oxygenationModified Delphi consensusPediatric evidenceRandomized trialsWeak recommendationAnticoagulationClinical recommendationsRecommendations AssessmentData extraction formMonitoring assaysLiterature searchDelphi consensusCochrane riskMoving beyond symptom reduction: A meta‐analysis on the effect of exposure therapy for PTSD on quality of life
Kaur K, Asnaani A, Levy H, Miller M, Tolin D, McLean C. Moving beyond symptom reduction: A meta‐analysis on the effect of exposure therapy for PTSD on quality of life. Journal Of Clinical Psychology 2024, 80: 2134-2146. PMID: 38875442, DOI: 10.1002/jclp.23727.Peer-Reviewed Original ResearchPosttraumatic stress disorderQuality of lifeExposure-based therapyExposure therapyControl conditionMeta-analysisPosttraumatic stress disorder treatment studiesAdult posttraumatic stress disorderEfficacy of exposure therapyEffectiveness of exposure therapyLow quality of lifeCochrane risk of bias toolRisk of bias toolExposure-based treatmentsFollow-upAssociated with greater improvementEmotional Well-BeingRisk of biasRandomized Controlled TrialsPTSD treatmentStress disorderPhysical healthSymptom reductionCochrane riskBias toolCurrent evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors
Yusuf R, Ng D, Torno L, Chan A. Current evidence of integrative oncology modalities for managing adverse effects and survivorship issues among adolescents and young adult (AYA) cancer patients and survivors. Current Opinion In Oncology 2024, 36: 211-222. PMID: 38842014, DOI: 10.1097/cco.0000000000001033.Peer-Reviewed Original ResearchConceptsMindfulness-based stress reductionPhysical activitySurvivorship issuesIntegrative oncologyCancer survivorsSymptom burdenAYA cancer survivorsYoung adult cancer patientsCochrane risk of biasSelf-management strategiesAYA cancer patientsCancer patientsAdult cancer patientsYoung adultsRisk of biasRandomized Controlled TrialsStructured exerciseCochrane riskCancer diagnosisStudy designAYAManage adverse effectsControlled TrialsStress reductionSurvivors
2023
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis
Tao D, Awan-Scully R, Ash G, Pei Z, Gu Y, Gao Y, Cole A, Baker J. The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis. Ageing Research Reviews 2023, 92: 102120. PMID: 37944706, PMCID: PMC11262040, DOI: 10.1016/j.arr.2023.102120.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentAlzheimer's diseaseOlder adultsCognitive impairmentCochrane Central RegisterMovement interventionNon-randomized studiesRisk of biasWeb of ScienceCentral RegisterCochrane riskSystematic scoping reviewBias toolControlled TrialsRandomized trialsRCT studiesMethodological qualityComplementary treatmentElectronic databasesIntervention studiesDance interventionDementiaDiseaseSystematic searchGlobal cognitionEpidemiology of substance use and mental health disorders among forced migrants displaced from the MENAT region: A systematic review and meta-analysis protocol
Kazemitabar M, Nyhan K, Makableh N, Minahan-Rowley R, Ali M, Wazaify M, Tetrault J, Khoshnood K. Epidemiology of substance use and mental health disorders among forced migrants displaced from the MENAT region: A systematic review and meta-analysis protocol. PLOS ONE 2023, 18: e0292535. PMID: 37797050, PMCID: PMC10553213, DOI: 10.1371/journal.pone.0292535.Peer-Reviewed Original ResearchConceptsMental health disordersSubstance use disordersSystematic reviewRegistration IDHealth disordersJoanna Briggs Institute checklistBias 2 toolRisk of biasInternational Prospective RegisterDatabases of EmbaseMeta-analysis protocolJoanna Briggs InstituteComprehensive systematic reviewRandom-effects modelSystematic review protocolCochrane riskMEDLINE search strategySubgroup analysisProspective RegisterRisk factorsObservational studyUse disordersHealth providersIntervention studiesDextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials
Akbar D, Rhee T, Ceban F, Ho R, Teopiz K, Cao B, Subramaniapillai M, Kwan A, Rosenblat J, McIntyre R. Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials. CNS Drugs 2023, 37: 867-881. PMID: 37792265, DOI: 10.1007/s40263-023-01032-5.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPathophysiology of MDDSystematic reviewMontgomery-Åsberg Depression Rating ScaleNMDA receptor antagonist dextromethorphanTransient adverse eventsRisk of biasDepression Rating ScaleMonoamine-based antidepressantsTreatment of depressionBackgroundA significant proportionPlacebo control groupCombination of dextromethorphanMechanism of actionConclusionCurrent evidenceClinical remissionAdverse eventsCochrane riskBias toolDatabase inceptionTreatment optionsScore reductionClinical trialsDepressive disorderActive control groupEfficacy of stimulants for preschool attention‐deficit/hyperactivity disorder: A systematic review and meta‐analysis
Sugaya L, Farhat L, Califano P, Polanczyk G. Efficacy of stimulants for preschool attention‐deficit/hyperactivity disorder: A systematic review and meta‐analysis. JCPP Advances 2023, 3: e12146. PMID: 37720577, PMCID: PMC10501696, DOI: 10.1002/jcv2.12146.Peer-Reviewed Original ResearchRandomized Controlled TrialsAttention-deficit/hyperactivity disorderCochrane riskRisk of bias of individual studiesAttention-deficit/hyperactivity disorder symptom severityDatabase inceptionCochrane risk of bias tool version 2Meta-analysisSystematic reviewPreschool attention-deficit/hyperactivity disorderGrading of recommendations assessmentConfidence of evidenceSynthesis of evidenceQuality of evidenceAll-cause dropout ratesTreatment recommendationsEvidence of heterogeneitySymptom severityPreschool childrenDouble-Blind Randomized Controlled TrialRandom-effects modelClinical Trials RegistryComparison to placeboAnalysis of efficacyRecommendations Assessment
2022
Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis
Bailey A, Maganti H, Cheng W, Shorr R, Buchan C, Allan D. Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis. Transplantation 2022, 107: 204-215. PMID: 36398334, PMCID: PMC9746229, DOI: 10.1097/tp.0000000000004386.Peer-Reviewed Original ResearchConceptsMRNA SARS-CoV-2 vaccineSARS-CoV-2 vaccinesTransplant recipientsThird doseSystematic reviewMeta-analysisNational Institutes of Health Quality Assessment ToolCochrane risk of bias toolAssociated with reduced oddsRisk of bias toolDose of mRNA SARS-CoV-2 vaccineMeta-Analysis reporting guidelinesQuality assessment toolHumoral responseSARS-CoV-2 mRNA vaccinesPreferred Reporting ItemsDerSimonian-Laird random-effects modelRandomized Controlled TrialsAdult transplant recipientsRandom-effects modelLack of controlled studiesClinically relevant thresholdsResponse to vaccinationCochrane riskReporting ItemsComparative cardiovascular side effects of medications for attention-deficit/hyperactivity disorder in children, adolescents and adults: protocol for a systematic review and network meta-analysis
Lannes A, Farhat L, Del Giovane C, Cipriani A, Revet A, Cortese S. Comparative cardiovascular side effects of medications for attention-deficit/hyperactivity disorder in children, adolescents and adults: protocol for a systematic review and network meta-analysis. BMJ Open 2022, 12: e062748. PMID: 36167386, PMCID: PMC9516066, DOI: 10.1136/bmjopen-2022-062748.Peer-Reviewed Original ResearchConceptsRandomised controlled trialsSystematic reviewNetwork Meta-AnalysisAttention-deficit/hyperactivity disorderCochrane Risk of Bias tool—version 2Meta-analysisCross-over randomised controlled trialConfidence of evidenceStandardised mean differencePreferred Reporting ItemsSide effects of medicationsMeta-Analysis guidelinesRisk of biasPeer-reviewed journalsNetwork Meta-Analysis toolDiagnosis of attention-deficit/hyperactivity disorderSafety of medicationsPrimary diagnosis of attention-deficit/hyperactivity disorderNo language restrictionsPublic health standpointBlood pressureEffects of medicationCochrane riskReporting ItemsSystolic blood pressureRandomized Clinical Trials of Machine Learning Interventions in Health Care
Plana D, Shung DL, Grimshaw AA, Saraf A, Sung JJY, Kann BH. Randomized Clinical Trials of Machine Learning Interventions in Health Care. JAMA Network Open 2022, 5: e2233946. PMID: 36173632, PMCID: PMC9523495, DOI: 10.1001/jamanetworkopen.2022.33946.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsRisk of biasClinical trialsSystematic reviewNon-RCT designHealth careCONSORT-AIClinical adoptionCochrane riskOvid EmbaseCochrane LibraryTrial characteristicsOvid MEDLINEPrimary interventionExclusion criteriaCommon reasonMedian proportionPatient careRCT designLiterature searchOverall riskRelevant articlesLack of participantsTrialsGoogle ScholarIndividualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis
Zorrilla-Vaca A, Grant M, Urman R, Frendl G. Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2022, 129: 815-825. PMID: 36031417, DOI: 10.1016/j.bja.2022.07.009.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureEnd-expiratory pressurePulmonary complicationsAbdominal surgerySystemic inflammationRisk ratioAcute respiratory distress syndromeLaird random-effects modelOverall pulmonary complicationsPostoperative pulmonary outcomesComposite primary outcomeEnd of surgerySystemic inflammatory markersRespiratory distress syndromeConfidence intervalsRandom-effects modelPostoperative atelectasisPrimary endpointPulmonary outcomesCochrane riskInflammatory markersLung injuryPostoperative hypoxaemiaSecondary outcomesBias tool
2021
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsAssociation Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19
Domingo P, Mur I, Mateo G, Gutierrez M, Pomar V, de Benito N, Corbacho N, Herrera S, Millan L, Muñoz J, Malouf J, Molas M, Asensi V, Horcajada J, Estrada V, Gutierrez F, Torres F, Perez-Molina J, Fortun J, Villar L, Hohenthal U, Marttila H, Vuorinen T, Nordberg M, Valtonen M, Frigault M, Mansour M, Patel N, Fernandes A, Harvey L, Foulkes A, Healy B, Shah R, Bensaci A, Woolley A, Nikiforow S, Lin N, Sagar M, Shrager H, Huckins D, Axelrod M, Pincus M, Fleisher J, Lampa J, Nowak P, Vesterbacka J, Rasmuson J, Skorup P, Janols H, Niward K, Chatzidionysiou K, Asgeirsson H, Parke Å, Blennow O, Svensson A, Aleman S, Sönnerborg A, Henter J, Horne A, Al-Beidh F, Angus D, Annane D, Arabi Y, Beane A, Berry S, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Cheng A, Cove M, De Jong M, Derde L, Estcourt L, Goossens H, Gordon A, Green C, Haniffa R, Ichihara N, Lamontagne F, Lawler P, Litton E, Marshall J, McArthur C, McAuley D, McGuinness S, McVerry B, Montgommery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Reyes F, Rowan K, Saito H, Santos M, Seymour C, Shankar-Hari M, Turgeon A, Turner A, van Bentum-Puijk W, van de Veerdonk F, Webb S, Zarychanski R, Baillie J, Beasley R, Cooper N, Fowler R, Galea J, Hills T, King A, Morpeth S, Netea M, Ogungbenro K, Pettila V, Tong S, Uyeki T, Youngstein T, Higgins A, Lorenzi E, Berry L, Salama C, Rosas I, Ruiz-Antorán B, Muñez Rubio E, Ramos Martínez A, Campos Esteban J, Avendaño Solá C, Pizov R, Sanz Sanz J, Abad-Santos F, Bautista-Hernández A, García-Fraile L, Barrios A, Gutiérrez Liarte Á, Alonso Pérez T, Rodríguez-García S, Mejía-Abril G, Prieto J, Leon R, VEIGA V, SCHEINBERG P, FARIAS D, PRATS J, CAVALCANTI A, MACHADO F, ROSA R, BERWANGER O, AZEVEDO L, LOPES R, DOURADO L, CASTRO C, ZAMPIERI F, AVEZUM A, LISBOA T, ROJAS S, COELHO J, LEITE R, CARVALHO J, ANDRADE L, SANDES A, PINTÃO M, SANTOS S, ALMEIDA T, COSTA A, GEBARA O, FREITAS F, PACHECO E, MACHADO D, MARTIN J, CONCEIÇÃO F, SIQUEIRA S, DAMIANI L, ISHIHARA L, SCHNEIDER D, DE SOUZA D, Hermine O, Mariette X, Tharaux P, Resche Rigon M, Porcher R, Ravaud P, Azoulay E, Cadranel J, Emmerich J, Fartoukh M, Guidet B, Humbert M, Lacombe K, Mahevas M, Pene F, Pourchet-Martinez V, Schlemmer F, Tibi A, Yazdanpanah Y, Dougados M, Bureau S, Horby P, Landray M, Baillie K, Buch M, Chappell L, Day J, Faust S, Haynes R, Jaki T, Jeffery K, Juszczak E, Lim W, Mafham M, Montgomery A, Mumford A, Thwaites G, Kamarulzaman A, Syed Omar S, Ponnampalavanar S, Raja Azwa R, Wong P, Kukreja A, Ong H, Sulaiman H, Basri S, Ng R, Megat Johari B, Rajasuriar R, Chong M, Neelamegam M, Syed Mansor S, Zulhaimi N, Lee C, Altice F, Price C, Malinis M, Hasan M, Wong C, Chidambaram S, Misnan N, Mohd Thabit A, Sim B, Bidin F, Mohd Abd Rahim M, Saravanamuttu S, Tuang W, Mohamed Gani Y, Thangavelu S, Tay K, Ibrahim N, Halid L, Tan K, Mukri M, Arip M, Koh H, Syed Badaruddin S, Raja Sureja L, Chun G, TORRE-CISNEROS J, MERCHANTE N, LEON R, CARCEL S, GARRIDO J, Galun E, Soriano A, Martínez J, Castán C, Paredes R, Dalmau D, Carbonell C, Espinosa G, Castro P, Muñóz J, Almuedo A, Prieto S, Pacheco I, Ratain M, Pisano J, Strek M, Adegunsoye A, Karrison T, Jozefien D, Karel F.A. V, Elisabeth D, Cedric B, Bastiaan M, Shankar-Hari M, Vale C, Godolphin P, Fisher D, Higgins J, Spiga F, Savovic J, Tierney J, Baron G, Benbenishty J, Berry L, Broman N, Cavalcanti A, Colman R, De Buyser S, Derde L, Domingo P, Omar S, Fernandez-Cruz A, Feuth T, Garcia F, Garcia-Vicuna R, Gonzalez-Alvaro I, Gordon A, Haynes R, Hermine O, Horby P, Horick N, Kumar K, Lambrecht B, Landray M, Leal L, Lederer D, Lorenzi E, Mariette X, Merchante N, Misnan N, Mohan S, Nivens M, Oksi J, Perez-Molina J, Pizov R, Porcher R, Postma S, Rajasuriar R, Ramanan A, Ravaud P, Reid P, Rutgers A, Sancho-Lopez A, Seto T, Sivapalasingam S, Soin A, Staplin N, Stone J, Strohbehn G, Sunden-Cullberg J, Torre-Cisneros J, Tsai L, van Hoogstraten H, van Meerten T, Veiga V, Westerweel P, Murthy S, Diaz J, Marshall J, Sterne J. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19. JAMA 2021, 326: 499-518. PMID: 34228774, PMCID: PMC8261689, DOI: 10.1001/jama.2021.11330.Peer-Reviewed Original ResearchConceptsIL-6 antagonistsUsual careCause mortalitySummary odds ratiosOdds ratioEligible trialsMechanical ventilationClinical trialsMortality riskSecondary infectionCOVID-19Primary outcome measureAbsolute mortality riskBias assessment toolRisk of biasStudy selection criteriaCochrane riskSecondary outcomesI2 statisticPlaceboOutcome measuresMAIN OUTCOMEPatientsAdditional trialsPrimary analysisSubcutaneous Ketamine in Depression: A Systematic Review
Cavenaghi V, da Costa L, Lacerda A, Hirata E, Miguel E, Fraguas R. Subcutaneous Ketamine in Depression: A Systematic Review. Frontiers In Psychiatry 2021, 12: 513068. PMID: 34122156, PMCID: PMC8193034, DOI: 10.3389/fpsyt.2021.513068.Peer-Reviewed Original ResearchRobust antidepressant effectsRacemic ketamineSystematic reviewAntidepressant effectsMultiple dosesDose-titration approachRandomized clinical trialsRisk of biasTransitory side effectsInclusion/exclusion criteriaPubMed/MEDLINESystematic literature searchWeb of ScienceSubcutaneous ketamineCochrane riskRemission rateBias toolRetrospective studyBeneficial efficacySC routeClinical trials
2020
Evaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors
Giri S, Grimshaw A, Bal S, Godby K, Kharel P, Djulbegovic B, Dimopoulos MA, Facon T, Usmani SZ, Mateos MV, Costa LJ. Evaluation of Daratumumab for the Treatment of Multiple Myeloma in Patients With High-risk Cytogenetic Factors. JAMA Oncology 2020, 6: 1759-1765. PMID: 32970151, PMCID: PMC7516804, DOI: 10.1001/jamaoncol.2020.4338.Peer-Reviewed Original ResearchConceptsProgression-free survivalHigh-risk MMBackbone regimensRefractory MMHazard ratioMultiple myelomaClinical trialsSystematic reviewDerSimonian-Laird random-effects modelPhase 3 trialImproved response ratesPreferred Reporting ItemsRandom-effects modelCochrane riskSame regimenCytogenetic riskCochrane LibraryMeeting libraryI2 statisticImproved outcomesMAIN OUTCOMEThird investigatorCochran's QPatientsReporting ItemsAssociation of Suicide Prevention Interventions With Subsequent Suicide Attempts, Linkage to Follow-up Care, and Depression Symptoms for Acute Care Settings
Doupnik SK, Rudd B, Schmutte T, Worsley D, Bowden CF, McCarthy E, Eggan E, Bridge JA, Marcus SC. Association of Suicide Prevention Interventions With Subsequent Suicide Attempts, Linkage to Follow-up Care, and Depression Symptoms for Acute Care Settings. JAMA Psychiatry 2020, 77: 1021-1030. PMID: 32584936, PMCID: PMC7301305, DOI: 10.1001/jamapsychiatry.2020.1586.Peer-Reviewed Original ResearchConceptsSubsequent suicide attemptsSuicide prevention interventionsStandardized mean differenceDepression symptomsPrevention interventionsSuicide attemptsClinical trialsMean differencePatient self-report measuresMedical record reviewAcute care settingReduced depression symptomsPooled-effect estimatesEgger's regression testSmall-study effectsMental health careRandom-effects modelEffect sizeSelf-report measuresCochrane riskBias toolPrimary outcomeRecord reviewStudy inclusionOvid MEDLINEEffectiveness and Safety of Ketamine for Unipolar Depression: a Systematic Review
Memon R, Naveed S, Faquih A, Fida A, Abbas N, Chaudhary A, Qayyum Z. Effectiveness and Safety of Ketamine for Unipolar Depression: a Systematic Review. Psychiatric Quarterly 2020, 91: 1147-1192. PMID: 32852658, DOI: 10.1007/s11126-020-09830-6.Peer-Reviewed Original ResearchConceptsMajor depressive disorderElectroconvulsive therapySystematic reviewTreatment optionsMajority of studiesSafety of ketamineTolerability of ketamineTreatment-resistant depressionEffective treatment optionPossible treatment optionsCommon psychiatric disordersPredetermined eligibility criteriaPreferred Reporting ItemsMeta-Analyses (PRISMA) checklistAntidepressant effectsCochrane riskIntranasal ketamineIntravenous ketamineAcute treatmentBias toolIN routeSocioeconomic burdenDepressive disorderMultiple infusionsAdequate sample size
2019
Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis
Ahmadzai N, Cheng W, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Esmaeilisaraji L, Kilty S, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: a protocol for a systematic review and meta-analysis. Systematic Reviews 2019, 8: 341. PMID: 31888735, PMCID: PMC6937806, DOI: 10.1186/s13643-019-1195-1.Peer-Reviewed Original ResearchConceptsSensorineural hearing lossMeniere's diseaseQuality of lifeSystematic reviewHearing-related disabilitySeverity of vertigoAttacks of vertigoIntractable Meniere's diseaseKey clinical trialsIntensity of tinnitusPre-specified eligibility criteriaCause of disabilityClinical treatment strategiesPlanned systematic reviewElectronic search strategyOptimal clinical treatment strategiesMedical information specialistBackgroundHearing lossVertigo attacksCochrane riskSurgical therapyBias toolSurgical interventionCochrane LibraryFuture trials
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