2025
A Review of Relapse in Opioid Use Disorder
Draghmeh K, Gold M, Fuehrlein B. A Review of Relapse in Opioid Use Disorder. Current Addiction Reports 2025, 12: 58. DOI: 10.1007/s40429-025-00672-5.Peer-Reviewed Original ResearchUse disorderEnhance treatment retentionMindfulness-based therapyStress system dysregulationRelapse vulnerabilityOpioid use disorderNeurobiological mechanismsDopamine deficitMedication-Assisted TreatmentContingency managementTreatment retentionPsychosocial interventionsMechanisms of relapseReduce relapseBehavioral componentsReviewOpioid use disorderSignificant public health challengeSystem dysregulationPublic health challengeRelapse rateAt-risk populationsSocietal burdenEmergency therapyAt-riskRelapseCancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications.
Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications. Journal Of Clinical Oncology 2025, 43: 10616-10616. DOI: 10.1200/jco.2025.43.16_suppl.10616.Peer-Reviewed Original ResearchLynch syndromeInherited cancer syndromeFamily historyPersonal historyCancer syndromesFamily history of colorectal cancerColorectal cancerPersonal history of cancerFamily history of cancerYale New Haven Health SystemLS-related cancersGenetic testingLS-associated cancersCancer genetic evaluationAt-riskIdentification of at-risk individualsAt-risk individualsPathogenic variantsLS cancersComparison of categorical variablesIndividuals at-riskEO-CRCPearson chi-squareHealth systemDescriptive statisticsAt-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes.
Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. At-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes. Journal Of Clinical Oncology 2025, 43: 1600-1600. DOI: 10.1200/jco.2025.43.16_suppl.1600.Peer-Reviewed Original ResearchHereditary cancer syndromesOvercome disparitiesAt-riskGenetic testingHereditary cancer syndrome identificationCancer genetic syndromesPreventable cancer deathsMedicaid-insured individualsComplexity of guidelinesAt-risk individualsPathogenic variantsIndividuals at-riskNon-white individualsDecline testingLynch syndromeUnderserved populationsHealth systemNon-HispanicCancer syndromesChi-square testEligible individualsFamily historyInformational videoCancer deathGenetic counselingIncidence and risk factors for subthreshold insomnia among U.S. military veterans: a population-based, longitudinal study
Nichter B, Hill M, Fischer I, Na P, Schnakenberg Martin A, Worley C, Pietrzak R. Incidence and risk factors for subthreshold insomnia among U.S. military veterans: a population-based, longitudinal study. Sleep Medicine 2025, 132: 106581. PMID: 40403448, DOI: 10.1016/j.sleep.2025.106581.Peer-Reviewed Original ResearchConceptsSubthreshold insomniaRisk factorsHealth-related risk factorsPopulation-based longitudinal dataAt-risk veteransPhysical health outcomesPopulation-based sampleTargeted prevention strategiesU.S. veteran populationKey risk factorsU.S. military veteransDegree of distressHealth outcomesPopulation-basedMultiple predisposingVeteran populationEmployment statusClinical insomniaMilitary veteransPrevention strategiesChronic painVeteransSleep difficultiesAt-riskLongitudinal studyPractical Guide on the Use of Induction Immunosuppression in Heart Transplantation.
Nikolova A, Bellumkonda L, Bhardwaj A, Fida N, Holzhauser L, Umapathi P, De Marco T, Contreras J. Practical Guide on the Use of Induction Immunosuppression in Heart Transplantation. Circulation Heart Failure 2025, e012382. PMID: 40371476, DOI: 10.1161/circheartfailure.124.012382.Peer-Reviewed Original ResearchInduction immunosuppressionHeart transplantationImpact of induction immunosuppressionHepatitis C positivityRenal protective strategiesRisk stratification modelAt-risk patientsInduction therapyInduction regimensCirculatory death donorsMalignant complicationsMechanical circulatory devicesPerioperative periodImmunomodulatory effectsRecipient riskImmunosuppressionDeath donorsStratification modelTransplantationTherapyPatientsCirculatory devicesAt-riskInductionElectronic health record-based registry for identification of individuals at risk for hereditary cancer syndromes
Singh V, Rafter T, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Xicola R, Kashyap N, Llor X. Electronic health record-based registry for identification of individuals at risk for hereditary cancer syndromes. Journal Of Medical Genetics 2025, 62: 457-463. PMID: 40350248, DOI: 10.1136/jmg-2025-110718.Peer-Reviewed Original ResearchConceptsHereditary cancer syndromesElectronic health recordsGenetic testingElectronic health record-based registryCancer syndromesIdentification of individualsFamily history of cancerFamily historyFamily history criteriaAt-riskHistory of cancerAt-risk individualsHealth recordsPathogenic variantsProspective identification of individualsRegistryActive patientsSyndrome identificationFamily relationshipsIncreased diagnostic rateCancer-related survivalStreamlined processProspective identificationIndividualsTesting needsDevelopment of a Suicide Prevention Intervention for Sexual and Gender Minority Youth and Young Adults: Rationale, Design, and Evidence of Feasibility and Acceptability
van der Star A, Randall A, Salgin L, Brady J, Albright C, Mitzner J, Alexander J, Williams K, Weersing V, Calzo J, Rojas S, Ramers C, Wells K, Blashill A. Development of a Suicide Prevention Intervention for Sexual and Gender Minority Youth and Young Adults: Rationale, Design, and Evidence of Feasibility and Acceptability. Suicide And Life-Threatening Behavior 2025, 55: e70014. PMID: 40179218, PMCID: PMC11968012, DOI: 10.1111/sltb.70014.Peer-Reviewed Original ResearchConceptsSafety Planning InterventionSGM youthPatient navigationStudy proceduresAcceptability of study proceduresGender minority youthYoung adultsSuicide prevention interventionsEvidence of feasibilityAt-risk populationsGender minoritiesMinority youthModular interventionRepeat-suicide attemptersPreventive interventionsPrevent SuicidePlanning interventionsAt-riskYouthCase seriesSatisfaction rateIdentical careInterventionTriangulated dataSGMVulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies
Mathis W, Berenbrok L, Kahn P, Appolon G, Tang S, Hernandez I. Vulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies. JAMA Network Open 2025, 8: e250715. PMID: 40080019, PMCID: PMC11907307, DOI: 10.1001/jamanetworkopen.2025.0715.Peer-Reviewed Original ResearchConceptsNational Council for Prescription Drug ProgramsPharmacy desertsSmall rural areasCross-sectional studyPharmacy accessCensus tractsPopulation-based cross-sectional studyRural areasLow-income areasHealth equityPrescription drug programPharmacy servicesMedication dispensingCommunity pharmaciesMain OutcomesTargeted policy interventionsPharmacy dataPrimary exposureSignificant disparitiesNearest pharmacyReimbursement ratesAt-riskPharmacyPublic healthPoint-of-care testingA computable electronic health record ARDS classifier recapitulates an association between the MUC5B promoter polymorphism and ARDS in critically ill adults.
Kerchberger V, McNeil J, Zheng N, Chang D, Rosenberger C, Rogers A, Bastarache J, Feng Q, Wei W, Ware L. A computable electronic health record ARDS classifier recapitulates an association between the MUC5B promoter polymorphism and ARDS in critically ill adults. CHEST Critical Care 2025, 100150. DOI: 10.1016/j.chstcc.2025.100150.Peer-Reviewed Original ResearchElectronic health recordsCritically Ill AdultsElectronic health record dataMUC5B Promoter PolymorphismIll adultsAt-risk adultsNegative predictive valuePositive predictive valueDiagnostic billing codesHealth recordsHospital participationGenetic risk factorsDNA biobanksBilling codesBioVUStudy designPromoter polymorphismCohort of critically ill adultsAt-riskCohen's kappaModerate agreementRisk factorsGenotyped cohortPredictive valueBiobankP577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system
Xicola R, Singh V, Chen G, Senna A, Pugliese A, Hughes M, Rafter T, Liu J, Brown Q, Haight C, Kashyap N, Llor X. P577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system. Genetics In Medicine Open 2025, 3: 102425. DOI: 10.1016/j.gimo.2025.102425.Peer-Reviewed Original Research
2024
Help-Seeking and Disclosure in University Students with Suicidal Thoughts and Self-Harm: A Systematic Review
Barnett P, Tickell A, Osborn T, Delamain H, Fonagy P, Pilling S, Gibbon L. Help-Seeking and Disclosure in University Students with Suicidal Thoughts and Self-Harm: A Systematic Review. International Journal Of Mental Health And Addiction 2024, 1-78. DOI: 10.1007/s11469-024-01416-8.Peer-Reviewed Original ResearchHelp-seekingSelf-harmSuicidal thoughtsRates of help-seekingImprove help-seekingSuicide prevention effortsEthnic minority groupsAt-risk groupsPopulation-basedMental healthReview synthesises researchQualitative studyPrevention effortsSystematic reviewPredictive of completed suicideAt-riskUniversity studentsMinority groupsUS-basedSuicidePsycEXTRAPsychINFOHealthMEDLINEInterventionT7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION
Garayua A, Nunez D, Nagamatsu S, Giusti-Rodriguez P, Martinez-Gonzalez K, Montalvo-Ortiz J. T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION. European Neuropsychopharmacology 2024, 87: 159. DOI: 10.1016/j.euroneuro.2024.08.317.Peer-Reviewed Original ResearchPost-traumatic stress disorderMajor depressive disorderCOVID-19 related stressorsCOVID-19 stressorsMajor depressive disorder symptomsPost-traumatic stress disorder symptomsAccelerated Epigenetic AgingRelated stressorsCombined sex analysesSymptoms of major depressive disorderPsychiatric disorder symptomsCOVID-19-related stressorsSex-stratified analysesSelf-report measuresCOVID-related stressorsAdverse mental health outcomesTargeted mental health interventionsSignificant stressorsAt-risk populationsMental health interventionsMental health outcomesConsequences of stressorsAccelerated biological agingEpigenetic ageAt-riskProspective Evaluation of Routine Statewide Integration of Molecular Epidemiology and Contact Tracing to Disrupt Human Immunodeficiency Virus Transmission
Kantor R, Steingrimsson J, Fulton J, Novitsky V, Howison M, Gillani F, Bhattarai L, MacAskill M, Hague J, Guang A, Khanna A, Dunn C, Hogan J, Bertrand T, Bandy U. Prospective Evaluation of Routine Statewide Integration of Molecular Epidemiology and Contact Tracing to Disrupt Human Immunodeficiency Virus Transmission. Open Forum Infectious Diseases 2024, 11: ofae599. PMID: 39474444, PMCID: PMC11521326, DOI: 10.1093/ofid/ofae599.Peer-Reviewed Original ResearchRoutine public health activitiesPublic health activitiesHealth activitiesAcademic-public health partnershipHIV transmissionNew HIV diagnosesHIV-TRACEHealth partnershipsHIV diagnosisIdentified barriersNewly-diagnosed individualsRoutine contactStatewide studyAt-riskAt-risk contactsIdentified gapsLongitudinal integrationInitial interviewContact tracingUnique individualsImproving contact tracingMolecular epidemiologyRhode IslandCommunity characteristicsMolecular cluster analysisThe efficacy of psychodynamic psychotherapy for young adults: a systematic review and meta-analysis
Trotta A, Gerber A, Rost F, Robertson S, Shmueli A, Perelberg R. The efficacy of psychodynamic psychotherapy for young adults: a systematic review and meta-analysis. Frontiers In Psychology 2024, 15: 1366032. PMID: 39295759, PMCID: PMC11408295, DOI: 10.3389/fpsyg.2024.1366032.Peer-Reviewed Original ResearchPsychodynamic psychotherapyMental health problemsPsychoanalytic psychotherapyYoung adultsEffectiveness of psychodynamic psychotherapyEfficacy of psychodynamic psychotherapyControl conditionRandomized Controlled TrialsMental health needsPsychodynamic interventionsTarget symptomsNaturalistic studyPsychotherapyPsychoanalytic interventionsSystematic reviewComparison treatmentYoung adulthoodAt-risk groupsClinical implicationsHealth problemsEfficacy of therapeutic interventionsMeta-analysisAt-riskAdultsPublished randomized controlled trialsEnhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging
Wu J, Lin K, Lu W, Zou W, Li X, Tan Y, Yang J, Zheng D, Liu X, Lam B, Xu G, Wang K, McIntyre R, Wang F, So K, Wang J. Enhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging. Biological Psychiatry 2024, 97: 313-322. PMID: 39069165, DOI: 10.1016/j.biopsych.2024.07.018.Peer-Reviewed Original ResearchAt-Risk AdolescentsBipolar disorderBehavioral assessmentBD patientsDiagnosis of bipolar disorderEarly diagnosis of bipolar disordersSevere neuropsychiatric conditionMultimodal MRIAt-riskBehavioral attributesEnhancing early diagnosisSubthreshold symptomsClinical InterviewPsychiatric symptomsNeuropsychiatric conditionsStructural equation modelingMultimodal neuroimagingGlobal functioningBrain healthBD diagnosisBD DiagnosticsAdvanced imaging techniquesSubgroup distinctionsAdolescentsRetrospective cohortUnraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan
Azab B, Aburizeg D, Shaaban S, Ji W, Mustafa L, Isbeih N, Al-Akily A, Mohammad H, Jeffries L, Khokha M, Lakhani S, Al-Ammouri I. Unraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan. Scientific Reports 2024, 14: 15141. PMID: 38956129, PMCID: PMC11219879, DOI: 10.1038/s41598-024-64921-9.Peer-Reviewed Original ResearchConceptsExome sequencingSarcomere-related genesMitochondrial-related diseasesAt-risk family membersGenetic architectureGenetic landscapePathogenic variantsGene panelPediatric cardiomyopathyMolecular underpinningsGenetic testingPhenocopiesSarcomeric cardiomyopathiesGenesSequenceStorage disorderFamily membersAt-riskVariantsEarly interventionExomeFamilyGlycogen storage disorderHypertrophic cardiomyopathyCardiomyopathyCognitive behavioral program for the prevention of depression in at-risk adolescents: isolating the effects of dose
Dickerson J, Clarke G, Weersing V, Lynch F, Hollon S, Brent D, Beardslee W, Gladstone T, Porta G, DeBar L, Brooks N, Garber J. Cognitive behavioral program for the prevention of depression in at-risk adolescents: isolating the effects of dose. American Journal Of Epidemiology 2024, 194: 19-26. PMID: 38904429, PMCID: PMC11735958, DOI: 10.1093/aje/kwae131.Peer-Reviewed Original ResearchDepression-free daysAt-Risk AdolescentsUsual careProgram doseAdolescent offspring of parentsIntention-to-treat sampleMulti-site randomized controlled trialAt-riskPrevention of depressionCognitive behavioral programOffspring of parentsHistory of depressionInfluence of confoundersRandomized Controlled TrialsIntervention doseAcute sessionAdolescent offspringTravel burdenPost-randomizationSecondary analysisBehavioral preventionBehavioral programFollow-up daysStudy variablesContinuous sessionPerspectives regarding cannabis use: Results from a qualitative study of individuals engaged in substance use treatment in Georgia and Connecticut
Warnock C, Ondrusek A, Edelman E, Kershaw T, Muilenburg J. Perspectives regarding cannabis use: Results from a qualitative study of individuals engaged in substance use treatment in Georgia and Connecticut. Drug And Alcohol Dependence Reports 2024, 11: 100228. PMID: 38585142, PMCID: PMC10997993, DOI: 10.1016/j.dadr.2024.100228.Peer-Reviewed Original ResearchSubstance use disordersCannabis useQualitative study of individualsSubstance use disorder treatment outcomesTreatment-related consequencesSemi-structured interviewsSubstance use treatmentSubstance Use InitiationStudy of individualsImprove healthPrescription medicationsQualitative studyHealth challengesMedicine beliefsPerceived cannabisTreatment cliniciansPeer perceptionsEntering treatmentAt-riskCannabisSocial servicesStudy objectiveYoung adulthoodInterviewsHealthAdolescents diagnosed with polycystic ovary syndrome under the Rotterdam criteria but not meeting the diagnosis under the updated guideline
Kim J, Hwang K, Lee D, Kim S, Choi Y. Adolescents diagnosed with polycystic ovary syndrome under the Rotterdam criteria but not meeting the diagnosis under the updated guideline. Human Reproduction 2024, 39: 1072-1077. PMID: 38514450, DOI: 10.1093/humrep/deae042.Peer-Reviewed Original ResearchPolycystic ovary syndromeRotterdam criteriaEvidence-based guidelinesAt-risk groupsAdolescent criteriaIrregular menstruationElevated serum LH levelsMetabolic profileDiagnosis of polycystic ovary syndromeFeatures of polycystic ovary syndromePolycystic ovary syndrome diagnosisSerum LH levelsPCOS-related symptomsInsulin resistance parametersYears post-menarcheAt-riskAnti-Mullerian hormoneInternational evidence-based guidelinesGynecological ageHigh blood pressureClinical characteristicsHirsutism scoreRetrospective studyMetabolic abnormalitiesFUNDING/COMPETING INTEREST(SAssociations of childhood BMI traits with blood pressure and glycated haemoglobin in 6–9‐year‐old Samoan children
Choy C, Johnson W, Braun J, Soti‐Ulberg C, Reupena M, Naseri T, Savusa K, Lupematasila V, Arorae M, Tafunaina F, Unasa F, Duckham R, Wang D, McGarvey S, Hawley N. Associations of childhood BMI traits with blood pressure and glycated haemoglobin in 6–9‐year‐old Samoan children. Pediatric Obesity 2024, 19: e13112. PMID: 38439600, PMCID: PMC11081844, DOI: 10.1111/ijpo.13112.Peer-Reviewed Original ResearchBody mass indexBody mass index velocityBody mass index trajectoriesChildhood BMI trajectoriesBlood pressureHigher Body Mass IndexChildhood characteristicsAssociation of HbA1cAssociated with higher BPAt-risk populationsSamoan childrenGlycated hemoglobinBMI trajectoriesPacific childrenPrevention effortsCohort studyElevated glycated hemoglobinHigher HbA1cMass indexHigh BPElevated BPYear oldsAt-riskMultilevel modelsRisk factors
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