2023
Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants.
Buck C, Shabanova V, Clark R, Taylor S. Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants. 2023, 152 PMID: 37969002, DOI: 10.1542/peds.2023-061285.Peer-Reviewed Original ResearchConceptsLate preterm infantsPreterm infantsGestational ageNeonatal morbidityBirth weightDay 14Pediatrix Clinical Data WarehouseNeonatal intensive care unitCommon neonatal morbiditiesShort-term morbidityIntensive care unitFirst postnatal dayPercent weight changeFirst postnatal weekClinical data warehouseDM groupRespiratory supportTerm morbidityCare unitDiabetes exposureAdjusted differenceCongenital anomaliesPostnatal dayHealth characteristicsPostnatal weekResponsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
Velez J, Karakala N, Tayebi K, Wickman T, Mohamed M, Kovacic R, Therapondos G, Kanduri S, Allegretti A, Belcher J, Regner K, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360 2023, 4: e448-e456. PMID: 36763632, PMCID: PMC10278824, DOI: 10.34067/kid.0000000000000068.Peer-Reviewed Original ResearchConceptsHepatorenal syndrome type 1Mean arterial pressureSyndrome type 1HRS-1Baseline SCrMAP riseType 1Serum creatinineArterial pressureKidney functionDay 14Baseline mean arterial pressureMean mean arterial pressureMedian mean arterial pressureEnd-stage liver diseaseMultivariate logistic regression analysisFavorable renal outcomeOptimal MAP targetsUse of norepinephrineLogistic regression analysisGreater reductionMedian sCrNorepinephrine useVasoconstrictor therapyRenal outcomes
2022
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
Xu L, Guo J, Moledina DG, Cantley LG. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nature Communications 2022, 13: 4892. PMID: 35986026, PMCID: PMC9391331, DOI: 10.1038/s41467-022-32634-0.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryT cellsChronic kidney disease transitionIschemia-reperfusion kidney injuryKidney disease transitionChronic kidney diseaseDepletion of neutrophilsGlomerular filtration rateT cell recruitmentTubular cell lossMacrophage persistenceProinflammatory neutrophilsTubule damageKidney atrophyContralateral kidneyNeutrophil numbersContralateral nephrectomyKidney diseaseTubule atrophyFiltration rateCell recruitmentMore macrophagesDay 14Day 5Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study
Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS. Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Medicine 2022, 48: 1144-1155. PMID: 35833959, PMCID: PMC9463324, DOI: 10.1007/s00134-022-06811-0.Peer-Reviewed Original ResearchConceptsPiperacillin-tazobactamKidney biomarkersCystatin CAcute kidney injury riskProspective cohort studyCystatin C concentrationCystatin C measurementKidney function biomarkersCreatinine secretionAntibiotic initiationCohort studyProspective cohortIll adultsClinical outcomesAssociation of vancomycinAntibiotic treatmentTubular secretionCreatinine concentrationTreatment weightingResultsThe studyTrue injuryHigh incidenceCreatinineDay 14Early changesA three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia
Wei S, Li J, He H, Shu C, Dardik A, Bai H. A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia. Smart Materials In Medicine 2022, 3: 139-147. DOI: 10.1016/j.smaim.2021.12.005.Peer-Reviewed Original Research
2020
Earlier Is Better: Evaluating the Timing of Tracheostomy After Liver Transplantation
Miller SM, Jean RA, Chiu AS, Oliveira K, Yoo PS. Earlier Is Better: Evaluating the Timing of Tracheostomy After Liver Transplantation. Respiratory Care 2020, 65: 1883-1888. PMID: 32788317, DOI: 10.4187/respcare.07519.Peer-Reviewed Original ResearchConceptsOrthotopic liver transplantationEarly tracheostomyLiver transplantationHospital mortalityRespiratory failureDay 14Cox proportional hazards modelCharlson Comorbidity IndexTiming of tracheostomyProportional hazards modelLate tracheostomyComorbidity indexProlonged hospitalizationFavorable outcomeRetrospective analysisTracheostomyHazards modelTransplantationPatient samplesMortalityStayQuick dischargeSubjectsHospitalizationFailure
2019
Liver retinol estimated by 13C-retinol isotope dilution at 7 versus 14 days in Burkinabe schoolchildren
Bationo J, Zeba A, Coulibaly N, Sheftel J, Davis C, Bassole I, Barro N, Ouedraogo J, Tanumihardjo S. Liver retinol estimated by 13C-retinol isotope dilution at 7 versus 14 days in Burkinabe schoolchildren. Experimental Biology And Medicine 2019, 244: 1430-1437. PMID: 31547685, PMCID: PMC6900701, DOI: 10.1177/1535370219877132.Peer-Reviewed Original ResearchConceptsBody surface areaTotal liver vitaminBlood drawLiver massBody weightDay 7Liver vitaminLiver weightDay 14TLR valuesBaseline blood drawSerum retinol concentrationsTotal-body vitaminTotal body storesDilution testingRetinol isotope dilutionPublic health programsLiver reserveLiver biopsyLiver retinolRetinol concentrationsSchool-aged childrenAdequate vitaminTracer doseBlood samplesThe association between fluconazole dose and MIC with mortality and persistence in candidemia
Ghanem-Zoubi N, Qasum M, Khoury J, Zorbavel D, Arnon M, Geffen Y, Paul M. The association between fluconazole dose and MIC with mortality and persistence in candidemia. European Journal Of Clinical Microbiology & Infectious Diseases 2019, 38: 1773-1780. PMID: 31197619, DOI: 10.1007/s10096-019-03611-1.Peer-Reviewed Original ResearchConceptsAUC24/MICClinical outcomesC. glabrata candidemiaComposite of mortalityExposure parametersLowest MIC valueSimilar non-significant differencesFluconazole doseFluconazole dosingPersistent candidemiaSingle centerMIC valuesClinical failureInclusion criteriaCandidemiaPatientsDay 14Non-significant differenceHigh MICsFluconazole MICsStudy periodMortalityCandida speciesMICC. glabrataA descriptive analysis of gut microbiota composition in differentially reared infant rhesus monkeys (Macaca mulatta) across the first 6 months of life
Dettmer AM, Allen JM, Jaggers RM, Bailey MT. A descriptive analysis of gut microbiota composition in differentially reared infant rhesus monkeys (Macaca mulatta) across the first 6 months of life. American Journal Of Primatology 2019, 81: e22969. PMID: 30941799, PMCID: PMC6774917, DOI: 10.1002/ajp.22969.Peer-Reviewed Original ResearchConceptsGut microbiota compositionMonths of lifeInfant rhesus monkeysMicrobiota compositionRhesus monkeysEarly life experiencesPostnatal day 14Gut microbial colonizationDay of birthHost immune functionNR infantsFed formulaClinical significanceImmune functionRectal swabsDaily social contactsDay 180Gut microbiotaDay 14Subsequent healthInfantsGastrointestinal microbiomeGut microbiomeSocial contactNovel findings
2016
Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure
Ter Maaten JM, Damman K, Hanberg JS, Givertz MM, Metra M, O'Connor CM, Teerlink JR, Ponikowski P, Cotter G, Davison B, Cleland JG, Bloomfield DM, Hillege HL, van Veldhuisen DJ, Voors AA, Testani JM. Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. Circulation Heart Failure 2016, 9 PMID: 27507112, DOI: 10.1161/circheartfailure.116.003109.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overBiomarkersChloridesDisease ProgressionDiureticsDown-RegulationDrug ResistanceFemaleHeart FailureHospitalizationHumansKaplan-Meier EstimateLinear ModelsMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRisk FactorsTime FactorsTreatment OutcomeXanthinesConceptsAcute heart failureMEq/L.Heart failureDay 14Serum chloridePoor diuretic responseHours of admissionLower serum chlorideBlood urea nitrogenSerum chloride levelsAHF therapiesDiuretic resistancePROTECT trialNeurohormonal activationMultivariable adjustmentRenal functionHospital admissionMultivariable analysisDiuretic responseDiuretic responsivenessDiuretic targetChloride levelsUrea nitrogenHypochloremiaChloride homeostasis
2015
Complications and mortality following surgery for oral cavity cancer: Analysis of 408 cases
Schwam ZG, Sosa JA, Roman S, Judson BL. Complications and mortality following surgery for oral cavity cancer: Analysis of 408 cases. The Laryngoscope 2015, 125: 1869-1873. PMID: 26063059, DOI: 10.1002/lary.25328.Peer-Reviewed Original ResearchConceptsOral cavity cancerPostdischarge complicationsPostoperative complicationsNeck dissectionNational Surgical Quality Improvement Program Participant Use Data FilesSurgeons National Surgical Quality Improvement Program Participant Use Data FilesSurgical siteDay 14Oral cavity cancer surgeryParticipant Use Data FilePostdischarge surgical-site infectionsCommon adverse eventsRetrospective cohort studySurgical site complicationsHigh-risk patientsModifiable risk factorsSurgical site infectionDisease-specific complicationsMultivariate regression analysisRespiratory complicationsAdverse eventsCohort studyCurrent smokersSite complicationsCancer surgeryThe Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury
Costine BA, Missios S, Taylor SR, McGuone D, Smith CM, Dodge CP, Harris BT, Duhaime AC. The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury. Developmental Neuroscience 2015, 37: 115-130. PMID: 25678047, PMCID: PMC4406780, DOI: 10.1159/000369091.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySubventricular zoneWhite matterWhite matter tractsNumber of neuroblastsPostnatal neurogenesisBrain injuryEffects of TBICortical impact modelPostnatal day 14Human infantsGyral white matterNeurogenic precursor cellsYounger age groupsMonths of ageSVZ areaPND 7Contralateral hemisphereGyrencephalic brainGyrencephalic speciesPiglet brainLesion siteLarge lesionsLesion sizeDay 14
2014
Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka
Agampodi S, Thevanesam V, Senaratne T. Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka. Sri Lankan Journal Of Infectious Diseases 2014, 4: 83. DOI: 10.4038/sljid.v4i2.6952.Peer-Reviewed Original ResearchIgM ELISADiagnosis of leptospirosisConvalescent samplesImmunoglobulin M enzymeDays of illnessComparison groupCases of leptospirosisIgM ELISA kitResultsThe study sampleDepartment of MicrobiologyCare diagnostic testsFebrile patientsAcute leptospirosisFever patientsAcute samplesFaculty of MedicineHuman leptospirosisDay 14Disease confirmationELISA kitLeptospirosisPatientsDiagnostic testsImmunosorbent assayStudy sampleEffectiveness of artesunate–amodiaquine vs. artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non‐inferiority randomised trial
Tinto H, Diallo S, Zongo I, Guiraud I, Valea I, Kazienga A, Kpoda H, Sorgho H, Ouédraogo J, Guiguemdé T, D'Alessandro U. Effectiveness of artesunate–amodiaquine vs. artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non‐inferiority randomised trial. Tropical Medicine And International Health 2014, 19: 469-475. PMID: 24494602, DOI: 10.1111/tmi.12274.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrineUncomplicated malariaFalciparum malariaUncomplicated falciparum malariaLow cure rateParents/guardiansAL armASAQ armParasitological responseFirst doseStudy nursesStudy armsRecrudescent infectionsCombination therapyCure rateTreatment administrationEndemic countriesDay 28Efficacy studiesNew infectionsDay 14Routine practiceMalariaBurkina FasoASAQ
2012
Transvaginal cholecystectomy versus single-incision laparoscopic cholecystectomy versus four-port laparoscopic cholecystectomy: a prospective cohort study
Solomon D, Shariff AH, Silasi DA, Duffy AJ, Bell RL, Roberts KE. Transvaginal cholecystectomy versus single-incision laparoscopic cholecystectomy versus four-port laparoscopic cholecystectomy: a prospective cohort study. Surgical Endoscopy 2012, 26: 2823-2827. PMID: 22549370, DOI: 10.1007/s00464-012-2253-0.Peer-Reviewed Original ResearchConceptsSingle-incision laparoscopic cholecystectomyFour-port laparoscopic cholecystectomyNumerical pain scaleProspective cohort studyLaparoscopic cholecystectomyTransvaginal cholecystectomyTVC groupOperative timePain scoresCohort studyPain scaleFirst prospective cohort studyLower pain scoresMean operative timeIncision laparoscopic cholecystectomyLonger operative timeResultsMean ageSILC groupLess painSingle incisionCholecystectomyDay 14POD 1PatientsDemographic data
2011
Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice
Lin T, Duek O, Dori A, Kofman O. Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice. International Journal Of Developmental Neuroscience 2011, 30: 113-120. PMID: 22197972, DOI: 10.1016/j.ijdevneu.2011.12.004.Peer-Reviewed Original ResearchConceptsLong-term effectsSwim testIrreversible acetylcholinesterase inhibitor diisopropylfluorophosphateBALB/c miceBALB/c strainPostnatal day 14BALB/cDifferential long-term effectsSub-toxic dosePostnatal administrationC miceMore immobilityDay 14Anxiety behaviorDFP pretreatmentC57BL/6J strainSweet preferenceConsecutive daysMouse strainsC strainMiceAge 3Term effectsFirst sessionSecond sessionPhysiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses
Dettmer AM, Novak MA, Suomi SJ, Meyer JS. Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses. Psychoneuroendocrinology 2011, 37: 191-199. PMID: 21715101, PMCID: PMC3196800, DOI: 10.1016/j.psyneuen.2011.06.003.Peer-Reviewed Original ResearchConceptsMonths of ageHair cortisolCortisol levelsAnxiety scoresMonth 6Anxious behaviorInfant monkeysMonths of lifeYears of ageElevated hair cortisolEarly life adversityElevated cortisol levelsAnxiety-related responsesRhesus monkey infantsHigher cortisol levelsHair cortisol concentrationsRapid physiological adaptationsMPR groupStress-related health problemsMonth 8PR groupSPR groupMajor life stressorsDay 14Cortisol concentrations
2009
A phase I study investigating the combination of orally bioavailable platinum and nanoparticle albumin-bound paclitaxel in advanced solid tumors
Deshpande H, Gettinger S, Rowen E, Abu-Khalaf M, Clarke J, Burns A, Kelly W. A phase I study investigating the combination of orally bioavailable platinum and nanoparticle albumin-bound paclitaxel in advanced solid tumors. Journal Of Clinical Oncology 2009, 27: e13501-e13501. DOI: 10.1200/jco.2009.27.15_suppl.e13501.Peer-Reviewed Original ResearchNanoparticle albumin-bound paclitaxelAlbumin-bound paclitaxelCohort 2Cohort 3Cohort 1Platinum agentsSolid tumorsDay 14Common severe adverse eventsGrade 3 anemiaMedian age 51Grade 4 neutropeniaStandard chemotherapy regimenAdvanced solid tumorsPhase 2 studySevere adverse eventsNeurological side effectsCycle 1Stable diseaseChemotherapy regimenDay 1 treatmentAdvanced malignanciesAdverse eventsPartial responseProgressive diseaseFactor VII–Verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization
Lu F, Hu Z, Sinard J, Garen A, Adelman RA. Factor VII–Verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science 2009, 50: 3890-3896. PMID: 19357351, DOI: 10.1167/iovs.08-2833.Peer-Reviewed Original ResearchConceptsVisudyne photodynamic therapyChoroidal neovascularizationCNV lesionsTargeted photodynamic therapyDay 7Rat modelSafety of PDTPhotodynamic therapyOcular side effectsBrown Norway ratsFrequency of leakageFluorescein angiographyEfficacious doseHistopathologic evaluationLaser photocoagulationSide effectsFactor VIIDay 14LesionsNormal vasculatureRatsEndothelial cellsTherapyDoseNeovascularizationIntestinal Permeability in Preterm Infants by Feeding Type: Mother's Milk Versus Formula
Taylor SN, Basile LA, Ebeling M, Wagner CL. Intestinal Permeability in Preterm Infants by Feeding Type: Mother's Milk Versus Formula. Breastfeeding Medicine 2009, 4: 11-15. PMID: 19196035, PMCID: PMC2932544, DOI: 10.1089/bfm.2008.0114.Peer-Reviewed Original ResearchConceptsFirst postnatal monthPreterm infantsIntestinal permeabilityHuman milkPostnatal monthMannitol ratioMother's milkDay 7Lactulose/mannitol ratioFormula-fed infantsDose-related mannerPostnatal day 7Low intestinal permeabilityEnteral feedingMannitol administrationNutritional agentsUrinary measurementsDay 14InfantsDay 30Majority of feedingsStudy periodTime pointsComplete study periodMonths
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