2025
Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis
Jin E, Ahmed A, Bekker L, Rousseau E, Dugdale C, Flanagan C, Wallace M, Freedberg K, Orrell C, Reddy K, Paltiel A, Ciaranello A, Neilan A. Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis. The Lancet Global Health 2025, 13: e1230-e1239. PMID: 40441175, DOI: 10.1016/s2214-109x(25)00119-6.Peer-Reviewed Original ResearchConceptsHIV pre-exposure prophylaxisPre-exposure prophylaxisLife yearsIncremental cost-effectiveness ratioTDF-FTCCAB-LAAdolescent girlsYoung womenHIV-related careHealth-care sector perspectiveDaily oral tenofovir disoproxil fumarateIncrease life-yearsDaily oral TDF-FTCOral tenofovir disoproxil fumaratePrEP programmesCumulative HIV-transmissionHIV incidencePrEP persistenceTenofovir disoproxil fumarateCost-effectiveness ratioHIV transmissionCost-effectiveModel-projected outcomesSouth AfricaPrEP drugsPrEP Navigator Perceptions of the Implementation of Injectable PrEP on HIV Prevention in Tennessee
Chandler C, Schlundt D, Dagostino C, Bonnet K, Sellers A, Pichon L, Alexander L. PrEP Navigator Perceptions of the Implementation of Injectable PrEP on HIV Prevention in Tennessee. International Journal Of Environmental Research And Public Health 2025, 22: 662. PMID: 40427779, PMCID: PMC12110792, DOI: 10.3390/ijerph22050662.Peer-Reviewed Original ResearchConceptsConsolidated Framework for Implementation ResearchLAI-PrEPInjectable PrEPHIV pre-exposure prophylaxisState health departmentsPre-exposure prophylaxisLong-actingSemi-structured interviewsPrEP navigationImplementation researchHealth departmentsHIV preventionStructural barriersAudio-recordedHealth insurancePrEPPharmaceutical policyUnited StatesPolicyQualitative approachHIVAlcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study
Castle A, Busang J, Dreyer J, Herbst C, Okesola N, Chimbindi N, Zuma T, Jarolimova J, Hahn J, Psaros C, Shenoi S, Shahmanesh M, Siedner M. Alcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study. AIDS And Behavior 2025, 1-12. PMID: 40185960, DOI: 10.1007/s10461-025-04694-y.Peer-Reviewed Original ResearchPrEP initiationHazardous alcohol useRural South AfricaAlcohol useOral HIV pre-exposure prophylaxisAlcohol consumptionHIV pre-exposure prophylaxisSouth AfricaPre-exposure prophylaxisImpact of alcohol useRisk alcohol useAlcohol use levelsAUDIT-C criteriaAlcohol use groupPrEP implementation effortsContinuum of careSexual health servicesOral PrEPHIV incidenceHazardous alcohol consumptionYoung menLogistic regression modelsSecondary data analysisInitiate PrEPNo/low riskRacial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study
Ajiboye W, Tharao W, Owino M, Soje L, Tian J, Ly A, Piyesis M, McLeod A, Fleury M, McBain K, Massaquoi N, Mosugu T, Swidrovich J, Tan D, Nelson L, Rourke S. Racial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study. Canadian Journal Of Public Health 2025, 116: 243-253. PMID: 40106208, PMCID: PMC12075050, DOI: 10.17269/s41997-025-01009-5.Peer-Reviewed Original ResearchConceptsPrEP awarenessPrEP eligibilityWhite participantsPrEP cascadeIndigenous menFunded health care systemHIV pre-exposure prophylaxisIncrease PrEP awarenessRural communitiesRacial differencesHealth care systemPublic health interventionsAssess racial differencesPre-exposure prophylaxisBinary logistic regressionCross-sectional dataPrEP carePrEP uptakeHealth interventionsCare systemDisproportionate burdenRacial disparitiesBlack participantsSecondary analysisPrEPP-500. Awareness and preferences for every 2 month long-acting injectable HIV Pre-Exposure Prophylaxis (PrEP) versus daily oral PrEP among cisgender women in the United States and the Dominican Republic
Metzner A, Oglesby A, O’Rourke A, Galai N, Karver T, Davis W, Scott R, Moriarty P, Taggart T, Barrington C, Gomez H, Perez M, Donastorg Y, Kerrigan D. P-500. Awareness and preferences for every 2 month long-acting injectable HIV Pre-Exposure Prophylaxis (PrEP) versus daily oral PrEP among cisgender women in the United States and the Dominican Republic. Open Forum Infectious Diseases 2025, 12: ofae631.699. PMCID: PMC11779361, DOI: 10.1093/ofid/ofae631.699.Peer-Reviewed Original ResearchHIV pre-exposure prophylaxisFemale sex workersOral PrEPPre-exposure prophylaxisLAI-PrEPDaily oral PrEPNumbers of sex partnersReproductive health clinicsSexual health clinicsHealth clinicsCisgender womenAcquired HIVHIV acquisitionLong-actingDaily pillInjectable PrEPPrEP clinicPrimary care clinicsPrEP useLatina ethnicityCondom useHIV knowledgeSex partnersPrEP awarenessHIV
2024
A PrEP decision aid for women survivors of intimate partner violence: Task-shifting implementation to domestic violence service settings
Meyer J, Lazarus E, Phillips K, Watts Z, Duroseau B, Carlson C, Price C, Kershaw T, Willie T. A PrEP decision aid for women survivors of intimate partner violence: Task-shifting implementation to domestic violence service settings. PLOS ONE 2024, 19: e0310837. PMID: 39288155, PMCID: PMC11407614, DOI: 10.1371/journal.pone.0310837.Peer-Reviewed Original ResearchConceptsIntimate partner violence survivorsIntimate partner violenceAgency staffPartner violenceHIV prevention interventionsService agenciesDomestic violence service agenciesSurvivors of intimate partner violenceWomen survivors of intimate partner violenceDomestic violence agenciesFemale IPV survivorsService delivery mechanismsHIV pre-exposure prophylaxisTrauma responseIPV survivorsPre-exposure prophylaxisPreventive health needsWomen survivorsPreventive interventionsQualitative interviewsStructural barriersAid interventionsHealth needsConsolidated Framework for Implementation ResearchAgenciesAdaptation of a Theory-Based Mobile App to Improve Access to HIV Prevention Services for Transgender Women in Malaysia: Focus Group Study
Gautam K, Shrestha R, Dlamini S, Razali B, Paudel K, Azwa I, Saifi R, Toh Y, Lim H, Sutherland R, Restar A, Phanuphak N, Wickersham J. Adaptation of a Theory-Based Mobile App to Improve Access to HIV Prevention Services for Transgender Women in Malaysia: Focus Group Study. JMIR Formative Research 2024, 8: e56250. PMID: 39137407, PMCID: PMC11350319, DOI: 10.2196/56250.Peer-Reviewed Original ResearchHIV prevention servicesTransgender womenFocus groupsPrEP uptakePreventive servicesCare servicesHIV preventionFG sessionsBarriers to PrEP uptakeUptake of HIV pre-exposure prophylaxisHIV pre-exposure prophylaxisTailored HIV preventionMobile appsReduce HIV vulnerabilityPre-exposure prophylaxisFocus group studyPrEP knowledgeTheater testingDedoose softwareMobile healthMultifaceted barriersDeliver interventionsHIV vulnerabilityPrEP barriersWomen's needsPrEP initiation and adherence among Black cisgender women in Mississippi: The role of HIV and PrEP stigma and social support
Knight D, Monger M, Phillips K, Antar A, Baral S, Stockman J, Nunn A, Chan P, Mayer K, Mena L, Kershaw T, Willie T. PrEP initiation and adherence among Black cisgender women in Mississippi: The role of HIV and PrEP stigma and social support. Women's Health 2024, 20: 17455057241296905. PMID: 39566475, PMCID: PMC11693850, DOI: 10.1177/17455057241296905.Peer-Reviewed Original ResearchConceptsBlack cisgender womenCisgender Black womenPrEP initiationSemi-structured interviewsSocial supportFocus groupsBlack womenHIV stigmaPrEP stigmaHIV preventionBarriers to HIV preventionCisgender womenLack of social supportLevels of social supportHIV pre-exposure prophylaxisImprove social supportAnticipated PrEP stigmaInductive thematic analysisSexual health clinicsAnalyzing focus groupsDecrease HIV transmissionWomen at-riskPre-exposure prophylaxisSocial support rolesPrEP indicationsReadiness to implement contingency management to promote PrEP initiation and adherence among people who inject drugs: results from a multi-site implementation survey
Pickering E, Viera A, Sung M, Davidson D, Bailey G, Buchelli M, Jenkins M, Kolakowski J, Maier L, Edelman E, Rash C. Readiness to implement contingency management to promote PrEP initiation and adherence among people who inject drugs: results from a multi-site implementation survey. Addiction Science & Clinical Practice 2024, 19: 97. PMID: 39710733, PMCID: PMC11665208, DOI: 10.1186/s13722-024-00503-4.Peer-Reviewed Original ResearchConceptsPromote HIV preventionCommunity-based organizationsHIV preventionHIV pre-exposure prophylaxisPrEP-related carePromote PrEP initiationHIV prevention activitiesIncentive-based interventionsTargeted HIV preventionReadiness of staffSelf-rated knowledgePre-exposure prophylaxisSurvey of staffFive-point Likert scalePrEP managementPrEP awarenessHIV testingPrEP uptakePrEP initiationTraining-relatedValues of individual itemsOutreach servicesMedication adherenceBeliefs QuestionnaireImplementation barriers
2023
Perspectives on unhealthy alcohol use among men who have sex with men prescribed HIV pre-exposure prophylaxis: A qualitative study
Strong S, Oldfield B, van den Berg J, Cole C, Biegacki E, Ogbuagu O, Virata M, Chan P, Edelman E. Perspectives on unhealthy alcohol use among men who have sex with men prescribed HIV pre-exposure prophylaxis: A qualitative study. Preventive Medicine Reports 2023, 37: 102553. PMID: 38282665, PMCID: PMC10810836, DOI: 10.1016/j.pmedr.2023.102553.Peer-Reviewed Original ResearchUnhealthy alcohol usePre-exposure prophylaxisAlcohol reduction interventionsAlcohol useHIV pre-exposure prophylaxisOral pre-exposure prophylaxisAcquisition of HIVAlcohol-related harmPrEP adherencePrEP careTreatment optionsOral formulationReduction interventionsPrEP programMSMPrEPProphylaxisHIVMultimodal approachMenCareAdherenceInterventionSexUnited States1536. Acceptability of an HIV Pre-Exposure Prophylaxis (PrEP) Shared Decision-Making Tool for Diverse Populations and Healthcare Providers
Davis W, Mantsios A, Metzner A, Talan A, Kwait J, Rodriguez H, Karver T, Barker S, Suarez A, Fernandez R, Rodriguez-Diaz C, Taggart T, Oglesby A, Garris C, Wohl D, Barrington C, Kerrigan D. 1536. Acceptability of an HIV Pre-Exposure Prophylaxis (PrEP) Shared Decision-Making Tool for Diverse Populations and Healthcare Providers. Open Forum Infectious Diseases 2023, 10: ofad500.1371. PMCID: PMC10677220, DOI: 10.1093/ofid/ofad500.1371.Peer-Reviewed Original ResearchPre-exposure prophylaxisHealthcare providersLA PrEPInjectable pre-exposure prophylaxisHIV pre-exposure prophylaxisExit interviewsPrEP conversationsClinic visitsPrEP knowledgePrEP useClinical visitsViiV HealthcarePrEP usersHIV preventionSide effectsFDA approvalCare optionsPrEPAcceptable deliveryKnowledge deficitsFormative researchProphylaxisVisitsMinor suggestionsDiverse populations1843. Exploring Cisgender Women's HIV Pre-Exposure Prophylaxis (PrEP) Needs and Preferences Across Settings: the Roles of Social-Structural Factors
Kerrigan D, Yonamine K, O’Rourke A, Karver T, Davis W, Metzner A, Oglesby A, Garris C, Scott R, Moriarty P, Taggart T, Barrington C, Gomez H, Perez M, Donastorg Y. 1843. Exploring Cisgender Women's HIV Pre-Exposure Prophylaxis (PrEP) Needs and Preferences Across Settings: the Roles of Social-Structural Factors. Open Forum Infectious Diseases 2023, 10: ofad500.1671. PMCID: PMC10678848, DOI: 10.1093/ofid/ofad500.1671.Peer-Reviewed Original ResearchSocial structural factorsFemale sex workersCisgender womenDominican RepublicHIV pre-exposure prophylaxisUnited StatesLA PrEPSocial structural constraintsNew HIV infectionsReproductive health servicesGender normsHealthcare providersInjectable PrEPThematic content analysisPrEP uptakeDepth interviewsHIV infectionPartner dynamicsSex workersEmpowerment toolReproductive healthcare providersDisproportionate impactPre-exposure prophylaxisTransgender womenContent analysisDaily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price
Amick A, Eskibozkurt G, Hosek S, Flanagan C, Landovitz R, Jin E, Wilson C, Freedberg K, Weinstein M, Kazemian P, Paltiel A, Ciaranello A, Neilan A. Daily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price. Clinical Infectious Diseases 2023, 78: 402-410. PMID: 37823865, PMCID: PMC10874274, DOI: 10.1093/cid/ciad566.Peer-Reviewed Original ResearchPre-exposure prophylaxisHIV incidenceRisk of HIVOral PrEPAnnual screeningHuman immunodeficiency virus (HIV) pre-exposure prophylaxisOral HIV pre-exposure prophylaxisHIV pre-exposure prophylaxisIncremental cost-effectiveness ratioHIV RNA levelsYoung menCost-effectiveness ratioAnnual HIVHigher discontinuationPrEP retentionAntiretroviral therapyDrug pricesHIV careLow adherenceLifetime horizonNew infectionsHIVIncidencePrEPRNA levels
2022
Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs
Sung M, Viera A, Esserman D, Tong G, Davidson D, Aiudi S, Bailey G, Buchanan A, Buchelli M, Jenkins M, John B, Kolakowski J, Lame A, Murphy S, Porter E, Simone L, Paris M, Rash C, Edelman E. Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs. Contemporary Clinical Trials 2022, 125: 107037. PMID: 36460267, PMCID: PMC9918697, DOI: 10.1016/j.cct.2022.107037.Peer-Reviewed Original ResearchConceptsAdherence support servicesHIV risk reductionPrEP adherenceContingency managementHybrid type 1 effectiveness-implementation trialHIV pre-exposure prophylaxisEffectiveness-implementation studyPre-exposure prophylaxisEffectiveness-implementation trialOpioid use disorderStrengths-based case managementRisk reductionSupport servicesCommunity-based programsPrEP initiationPrimary outcomeWeek 12Clinical trialsHIV preventionUse disordersCM sessionsCase managementBlood spotsPWIDStudy designProactive strategies to optimize engagement of Black, Hispanic/Latinx, transgender, and nonbinary individuals in a trial of a novel agent for HIV pre-exposure prophylaxis (PrEP)
Cespedes M, Das M, Hojilla JC, Blumenthal J, Mounzer K, Ramgopal M, Hodge T, Torres TS, Peterson C, Shibase S, Elliott A, Demidont AC, Callaghan L, Watson CC, Carter C, Kintu A, Baeten JM, Ogbuagu O. Proactive strategies to optimize engagement of Black, Hispanic/Latinx, transgender, and nonbinary individuals in a trial of a novel agent for HIV pre-exposure prophylaxis (PrEP). PLOS ONE 2022, 17: e0267780. PMID: 35657826, PMCID: PMC9165827, DOI: 10.1371/journal.pone.0267780.Peer-Reviewed Original ResearchConceptsClinical trialsHIV incidencePre-exposure prophylaxis clinical trialHispanic/LatinxRecruitment goalsGood participatory practice guidelinesOngoing phase 3 trialsHIV pre-exposure prophylaxisTransgender womenTransgender menPhase 3 trialPre-exposure prophylaxisCommunity-based clinicsFuture clinical trialsClinical trial numberEvidence-informed recommendationsLatinx MSMGender nonbinary individualsCisgender MSMNovel agentsPractice guidelinesStudy populationBlack MSMUS sitesTrials
2021
Barriers and facilitators to pre-exposure prophylaxis uptake among male sex workers in Mexico: an application of the RE-AIM framework
Kadiamada-Ibarra H, Hawley NL, Sosa-Rubí SG, Wilson-Barthes M, Franco RR, Galárraga O. Barriers and facilitators to pre-exposure prophylaxis uptake among male sex workers in Mexico: an application of the RE-AIM framework. BMC Public Health 2021, 21: 2174. PMID: 34837988, PMCID: PMC8626882, DOI: 10.1186/s12889-021-12167-9.Peer-Reviewed Original ResearchConceptsMale sex workersPre-exposure prophylaxisHigh-risk populationPrEP distributionProgram reachSex workersRE-AIM implementation science frameworkHIV pre-exposure prophylaxisAdoption of PrEPRE-AIM frameworkPatient-centered careLow socioeconomic statusPrimary qualitative analysisImplementation science frameworkPrEP knowledgeHIV infectionAdherence barriersPrEP adoptionPrEP educationHIV preventionHigh riskMethodsThis studyStreet-based sex workersTransgender womenHIVFeasibility of a community‐based delivery model for HIV pre‐exposure prophylaxis among bar patrons in rural South Africa
Grammatico MA, Moll AP, Choi K, Springer SA, Shenoi SV. Feasibility of a community‐based delivery model for HIV pre‐exposure prophylaxis among bar patrons in rural South Africa. Journal Of The International AIDS Society 2021, 24: e25848. PMID: 34826363, PMCID: PMC8625837, DOI: 10.1002/jia2.25848.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisAlcohol Use Disorders Identification TestLargest HIV epidemicCommunity-based delivery modelPrEP uptakeHIV testingOdds ratioOral tenofovir disoproxil fumarate/emtricitabineTenofovir disoproxil fumarate/emtricitabineRural South AfricaHazardous drinkingDisoproxil fumarate/emtricitabineHIV pre-exposure prophylaxisUptake of PrEPHIV care cascadeRapid HIV testingAdjusted odds ratioYoung menRural KwaZulu-Natal ProvinceAlcohol use disorderSexual risk behaviorsDisorders Identification TestBar patronsPrEP deliveryPrEP initiators“We’ve Got Our Own Beliefs, Attitudes, Myths”: A Mixed Methods Assessment of Rural South African Health Care Workers' Knowledge of and Attitudes Towards PrEP Implementation
Asabor EN, Lett E, Moll A, Shenoi SV. “We’ve Got Our Own Beliefs, Attitudes, Myths”: A Mixed Methods Assessment of Rural South African Health Care Workers' Knowledge of and Attitudes Towards PrEP Implementation. AIDS And Behavior 2021, 25: 2517-2532. PMID: 33763802, PMCID: PMC8450017, DOI: 10.1007/s10461-021-03213-z.Peer-Reviewed Original ResearchConceptsLocal healthcare workersHealthcare workersPrEP implementationHealth care workers' knowledgeHIV pre-exposure prophylaxisSkilled clinical staffPre-exposure prophylaxisImpact of HIVPrEP interventionsHIV prevalenceHCW roleClinical staffTravel burdenMixed-methods assessmentDisproportionate burdenHIVWorkers' knowledgeAdditional concernsSexual behaviorBlack South AfricansBarriers researchersPrEPRisk compensationBurdenImplementation scientistsChapter 11 HIV pre-exposure prophylaxis for people who inject drugs
Shrestha R, McCoy-Redd B, Meyer J. Chapter 11 HIV pre-exposure prophylaxis for people who inject drugs. 2021, 223-236. DOI: 10.1016/b978-0-323-68328-9.00011-4.Peer-Reviewed Original ResearchHIV preventionEffective HIV prevention toolHigh-risk sexual networksHIV pre-exposure prophylaxisLimited clinical trial dataSubstance usePre-exposure prophylaxisHIV prevention toolClinical trial dataHarm reduction programsKey target populationSubstance use disordersPart of patientsTarget populationPrEP outcomesPreexposure prophylaxisMedication adherenceHIV riskUse disordersTrial dataPWIDSexual networksPrEPPrevention toolProphylaxis
2020
102. Improving Implementation of HIV Pre-exposure Prophylaxis: Lessons Learned from Young Women in Rural South Africa
Hannaford A, Khumalo N, Norton S, Moll A, Shenoi S. 102. Improving Implementation of HIV Pre-exposure Prophylaxis: Lessons Learned from Young Women in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s180-s181. PMCID: PMC7777701, DOI: 10.1093/ofid/ofaa439.412.Peer-Reviewed Original ResearchPrEP delivery modelsPre-exposure prophylaxisYoung womenPrEP initiationHIV pre-exposure prophylaxisSexual activityCommunity health workersInconsistent condom useHIV prevention programsMale sexual partnersCommunity-based deliveryPrEP deliveryMedication refillsPrEP implementationPrEP useDelivery modelPrEP educationHIV stigmaHealth workersHigh riskPrEP disclosureProgrammatic conditionsClinic facilitiesRural South AfricaCondom use
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