2025
Impact of multi-level factors and partner characteristics on antiretroviral therapy adherence and access to HIV care during the COVID-19 pandemic
Neuenschwander P, Pala A, Altice F, Remien R, Mergenova G, Rozental E, Gulyayev V, Davis A. Impact of multi-level factors and partner characteristics on antiretroviral therapy adherence and access to HIV care during the COVID-19 pandemic. International Journal Of STD & AIDS 2025, 36: 568-576. PMID: 40155324, DOI: 10.1177/09564624251329626.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy adherenceMental healthFactors associated with ART adherenceMethodsA cross-sectional surveyMultilevel generalized linear mixed modelsPoor mental healthAssociated with lower adherenceBackgroundAdherence to antiretroviral therapyAntiretroviral therapyMedication adherence ratesCross-sectional surveyCOVID-19 pandemicHIV treatment programsMulti-level factorsNegative emotional impactHIV carePublic health crisisSocial supportART adherenceSupportive partnersLinear mixed modelsAdherence ratesAssessed associationsLow adherenceAdherence levels
2024
Data-driven insights into neighborhood adherence to cancer prevention guidelines in Philadelphia
DuBois T, Moore K, Rollins H, Silbaugh J, Sorice K, Lynch S. Data-driven insights into neighborhood adherence to cancer prevention guidelines in Philadelphia. PLOS ONE 2024, 19: e0313334. PMID: 39565787, PMCID: PMC11578512, DOI: 10.1371/journal.pone.0313334.Peer-Reviewed Original ResearchConceptsCancer prevention guidelinesAdherence to cancer prevention guidelinesCancer mortalityGuideline adherencePrevention guidelinesPhysical activityLow cancer screening ratesAmerican Cancer Society guidelinesLow adherenceCancer prevention recommendationsCancer screening ratesLower guideline adherenceHighest cancer burdenBehavioral risk factorsPublic health officialsScreening ratesExcessive alcohol consumptionPreventive servicesCancer burdenPoor healthRecommendation adherencePrevention recommendationsHealthy livingCancer casesModify risk
2023
Daily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price
Amick A, Eskibozkurt G, Hosek S, Flanagan C, Landovitz R, Jin E, Wilson C, Freedberg K, Weinstein M, Kazemian P, Paltiel A, Ciaranello A, Neilan A. Daily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price. Clinical Infectious Diseases 2023, 78: 402-410. PMID: 37823865, PMCID: PMC10874274, DOI: 10.1093/cid/ciad566.Peer-Reviewed Original ResearchPre-exposure prophylaxisHIV incidenceRisk of HIVOral PrEPAnnual screeningHuman immunodeficiency virus (HIV) pre-exposure prophylaxisOral HIV pre-exposure prophylaxisHIV pre-exposure prophylaxisIncremental cost-effectiveness ratioHIV RNA levelsYoung menCost-effectiveness ratioAnnual HIVHigher discontinuationPrEP retentionAntiretroviral therapyDrug pricesHIV careLow adherenceLifetime horizonNew infectionsHIVIncidencePrEPRNA levels
2022
Bedaquiline Adherence Measured by Electronic Dose Monitoring Predicts Clinical Outcomes in the Treatment of Patients With Multidrug-Resistant Tuberculosis and HIV/AIDS
O'Donnell MR, Padayatchi N, Wolf A, Zelnick J, Daftary A, Orrell C, Nimmo C, Baldwin M, Boodhram R, Maharaj B, Amico KR, Naidoo K, Friedland G. Bedaquiline Adherence Measured by Electronic Dose Monitoring Predicts Clinical Outcomes in the Treatment of Patients With Multidrug-Resistant Tuberculosis and HIV/AIDS. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 90: 325-332. PMID: 35195572, PMCID: PMC11077859, DOI: 10.1097/qai.0000000000002940.Peer-Reviewed Original ResearchConceptsMDR-TB treatment outcomesResistance-associated variantsTreatment outcomesAntiretroviral therapyMDR-TBART adherenceMultidrug-resistant tuberculosis treatmentHIV treatment outcomesProspective cohort studyMultidrug-resistant tuberculosisEnd of treatmentTreatment of patientsSuccessful treatment outcomeElectronic dose monitoring devicesHIV/AIDSCohort studyClinical outcomesMultivariable analysisNovel regimensMedication adherenceAdherence thresholdTuberculosis treatmentTreatment completionLow adherenceDose monitoringViral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone
Gonzales P, Bachireddy C, Grieco A, Ding R, de Leon S, Ulrich A, Lama J, Duerr AC, Altice FL. Viral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 89: 462-471. PMID: 34897226, PMCID: PMC8881312, DOI: 10.1097/qai.0000000000002889.Peer-Reviewed Original ResearchConceptsMSM/transgender womenAlcohol use disorderOral naltrexoneTransgender womenViral suppressionUse disordersEFV/TDF/FTCTreatment of AUDMaximal viral suppressionSingle treatment regimenPlacebo-controlled trialTDF/FTCAntiretroviral therapy adherenceUse of naltrexoneEvidence-based treatmentsViral suppression levelsMVs levelsSecondary outcomesTherapy adherenceLow adherenceAdherence levelsNaltrexoneAUD treatmentHIVPlaceboPatient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study
Galarza-Prado A, Zorrilla-Vaca A, Healy R, Ripollés J, Abad-Motos A, Nozal-Mateo B, Del Rio S, Caballero-Lozada A, Stone A, Mena G, Grant M. Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study. Journal Of Gastrointestinal Surgery 2022, 26: 911-916. PMID: 35059982, DOI: 10.1007/s11605-021-05234-4.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseColorectal surgeryPreoperative hypoalbuminemiaPreoperative transfusionPatient characteristicsArtery diseaseHigh adherenceRecovery protocolMultivariable logistic regression analysisEnhanced recovery protocolMulticentric prospective studyLow complication rateLogistic regression analysisClinical characteristicsComplication rateMetastatic diseaseSurgical characteristicsCancer resectionSurgery guidelinesProspective studyAdequate adherenceUnivariate analysisLow adherenceMultivariable modelPatients
2021
Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapyRacial Differences in Adherence to Lung Cancer Screening Follow-up A Systematic Review and Meta-analysis
Kunitomo Y, Bade B, Gunderson CG, Akgün KM, Brackett A, Cain H, Tanoue L, Bastian LA. Racial Differences in Adherence to Lung Cancer Screening Follow-up A Systematic Review and Meta-analysis. CHEST Journal 2021, 161: 266-275. PMID: 34390706, DOI: 10.1016/j.chest.2021.07.2172.Peer-Reviewed Original ResearchConceptsLung cancer screeningLung cancer mortalityCancer mortalityCancer screeningLow adherenceSystematic reviewAnnual lung cancer screeningLung cancer mortality benefitLow-dose chest CTEligible black patientsAllied Health Literature databasesA Systematic ReviewRate of adherenceHigh-risk individualsUnited States Preventive Services TaskforceFull-text reviewHealth Literature databasesWeb of ScienceLCS adherenceLCS participationBlack populationMortality benefitWhite patientsBlack patientsInitial screening results
2020
Feasibility of implementing a text-based symptom-monitoring program of endometrial, ovarian, and breast cancer patients during treatment
Naughton MJ, Salani R, Peng J, Lustberg M, DeGraffinreid C, Moon J, Loyan H, Beverly Hery CM, Paskett ED. Feasibility of implementing a text-based symptom-monitoring program of endometrial, ovarian, and breast cancer patients during treatment. Quality Of Life Research 2020, 30: 3241-3254. PMID: 33052514, PMCID: PMC8528739, DOI: 10.1007/s11136-020-02660-w.Peer-Reviewed Original ResearchConceptsBreast cancer patientsCancer patientsPatient Health QuestionnaireOverall mean ageHealth care teamNon-medical needsNon-Hispanic whitesLay navigatorsPatient navigationMean ageSleep disturbancesCare teamHealth QuestionnaireLow adherencePatient responseAverage adherenceSleep qualitySymptom monitoringBreast patientsPatientsCancer typesMonthly feedbackMonthsGlobal qualitySymptomsAdherence to antihypertensive medication and its predictors among non-elderly adults in Japan
Nishimura S, Kumamaru H, Shoji S, Sawano M, Kohsaka S, Miyata H. Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan. Hypertension Research 2020, 43: 705-714. PMID: 32313192, DOI: 10.1038/s41440-020-0440-2.Peer-Reviewed Original ResearchConceptsLow adherenceAntihypertensive medicationsAntihypertensive drugsJapanese patientsLarge administrative claims databaseAntihypertensive drug usersInitiation of angiotensinAdministrative claims databaseSuboptimal clinical outcomesProportion of daysNon-elderly adultsLogistic regression analysisHypertensive patientsThiazide diureticsClinical outcomesClaims databaseFemale sexHigh adherencePatientsEnzyme inhibitorsDrug usersYounger ageTargeted interventionsFacility characteristicsLarge hospitals
2019
Sociodemographic factors affecting viral load suppression among people living with HIV in South Carolina
Haider M, Brown M, Harrison S, Yang X, Ingram L, Bhochhibhoya A, Hamilton A, Olatosi B, Li X. Sociodemographic factors affecting viral load suppression among people living with HIV in South Carolina. AIDS Care 2019, 33: 290-298. PMID: 31856584, PMCID: PMC7302958, DOI: 10.1080/09540121.2019.1703892.Peer-Reviewed Original ResearchConceptsViral suppressionSociodemographic factorsAntiretroviral therapyART adherenceLower ART adherenceViral load suppressionRecent viral loadMost recent viral loadHIV careViral loadLow adherenceAdherence levelsHigher oddsPLWHHealthcare providersBivariate analysisLarge clinicsTargeted interventionsLogistic regressionCross-sectional dataAdherenceSociodemographic groupsHIVSecondary transmissionOdds
2018
Depressive Symptoms Are Associated With Low Treatment Adherence in African American Individuals With Systemic Lupus Erythematosus
Heiman E, Lim S, Bao G, Drenkard C. Depressive Symptoms Are Associated With Low Treatment Adherence in African American Individuals With Systemic Lupus Erythematosus. JCR Journal Of Clinical Rheumatology 2018, 24: 368-374. PMID: 29912774, PMCID: PMC6487191, DOI: 10.1097/rhu.0000000000000794.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLow medication adherencePopulation-based cohortMedication adherenceDepressive symptomsLow adherenceLupus erythematosusFemale sexYounger ageHigher disease activity scoresMorisky Medication Adherence ScaleLogistic regressionDisease Activity ScoreLow treatment adherenceMedication Adherence ScalePatient Health QuestionnaireSevere depressive symptomsSignificant risk factorsPatient-physician communicationUnivariate logistic regressionAA individualsPhysician communication styleMental health interventionsLupus CohortMultiple medicationsExploring Antidepressant Adherence at a Student-Run Free Mental Health Clinic
Mann C, Rifkin R, Nabel E, Thomas D, Meah Y, Katz C. Exploring Antidepressant Adherence at a Student-Run Free Mental Health Clinic. Community Mental Health Journal 2018, 55: 57-62. PMID: 30062631, DOI: 10.1007/s10597-018-0301-5.Peer-Reviewed Original ResearchConceptsEast Harlem Health Outreach PartnershipNew York StateMental healthStudent-runNew York State MedicaidAcute treatment phaseMental health clinicsLow treatment ratesHEDIS criteriaMH clinicsAntidepressant adherenceHealth clinicsPhysician notesDepression treatmentAdherence ratesMeasure adherenceLow adherencePharmacy dataTreatment phaseTreatment ratesInsurance providersAdherenceMinority groupsMedicaidClinicBarriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study
Hennein R, Hwang S, Au R, Levy D, Muntner P, Fox CS, Ma J. Barriers to medication adherence and links to cardiovascular disease risk factor control: the Framingham Heart Study. Internal Medicine Journal 2018, 48: 414-421. PMID: 29193523, PMCID: PMC5889324, DOI: 10.1111/imj.13687.Peer-Reviewed Original ResearchConceptsCVD risk factorsMini-Mental State ExaminationMedication adherenceLow adherenceRisk factorsFramingham Heart StudyCardiovascular diseaseDepressive symptomsHeart StudyCardiovascular disease risk factor controlHigher mean diastolic blood pressureMean low-density lipoprotein cholesterolFour-item Morisky Medication Adherence ScaleMean diastolic blood pressureMedian age 70 yearsLow-density lipoprotein cholesterolMorisky Medication Adherence ScaleFive-unit increaseRisk factor controlLipid-lowering medicationsDiastolic blood pressureMedication Adherence ScaleAge 70 yearsLow medication adherenceCES-D scores
2017
Trends in Omalizumab Utilization for Asthma: Evidence of Suboptimal Patient Selection
Jeffery MM, Shah ND, Karaca-Mandic P, Ross JS, Rank MA. Trends in Omalizumab Utilization for Asthma: Evidence of Suboptimal Patient Selection. The Journal Of Allergy And Clinical Immunology In Practice 2017, 6: 1568-1577.e4. PMID: 28958746, DOI: 10.1016/j.jaip.2017.07.034.Peer-Reviewed Original ResearchConceptsOmalizumab initiationAsthma controlICS-LABAPatient selectionLow adherenceBetter asthma controlCohort of nonusersSuboptimal patient selectionPoor asthma controlLow adherence ratesPatient-level characteristicsLarge US databaseMedicare Advantage beneficiariesAsthma biologicsExacerbation frequencyOmalizumab useIncident useComparison cohortICS/Medication adherenceAdherence ratesPrevalent usersAdministrative claimsAsthmaUtilization trends
2016
The Effect of Chronic Kidney Disease on a Physical Activity Intervention: Impact on Physical Function, Adherence, and Safety
Liu C, Milton J, Hsu F, Beavers K, Yank V, Church T, Shegog J, Kashaf S, Nayfield S, Newman A, Stafford R, Nicklas B, Weiner D, Fielding R, Group L. The Effect of Chronic Kidney Disease on a Physical Activity Intervention: Impact on Physical Function, Adherence, and Safety. Journal Of Clinical Nephrology And Renal Care 2016, 3: 21. PMID: 29745380, PMCID: PMC5937279, DOI: 10.23937/2572-3286.1510021.Peer-Reviewed Original ResearchShort Physical Performance BatteryChronic kidney diseaseSerious adverse eventsPhysical activity programPhysical activity interventionsCKD participantsOlder adultsKidney diseaseActivity interventionsPhysical activityBaseline short physical performance batteryMean SPPBTypes of SAEsBaseline chronic kidney diseaseLIFE-P studyNon-CKD participantsPhysical Performance BatteryPhysical function deficitsInteraction of interventionBaseline eGFRMean eGFRAdverse eventsSecondary outcomesPhysical functionLow adherence
2015
Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial
Abbeddou S, Hess S, Yakes Jimenez E, Somé J, Vosti S, Guissou R, Ouédraogo J, Brown K. Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial. Maternal And Child Nutrition 2015, 11: 90-104. PMID: 25521188, PMCID: PMC6860357, DOI: 10.1111/mcn.12162.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPlasma zinc concentrationDispersible tabletsLipid-based nutrient supplementsCaregiver-reported adherenceMonths of supplementationDisappearance rateMonths of ageSubgroup of childrenWeekly adherenceIntervention trialsClinical trialsLow adherenceSupplementation trialAdherence dataHome visitsCaregiver interviewsZinc tabletsLack of changeChildren 11Zinc concentrationsStudy outcomesObservation periodAdherenceMonthsAdherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy
Viswanathan S, Justice AC, Alexander GC, Brown TT, Gandhi NR, McNicholl IR, Rimland D, Rodriguez-Barradas MC, Jacobson LP. Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 493-498. PMID: 25886923, PMCID: PMC4482798, DOI: 10.1097/qai.0000000000000643.Peer-Reviewed Original ResearchConceptsHIV RNA suppressionOdds of suppressionActive antiretroviral therapyRNA suppressionHAART regimenAntiretroviral therapyVeterans Aging Cohort Study Virtual CohortHighly active antiretroviral therapyFirst HAART regimenProtease inhibitor usersRepeated-measures logistic regressionVeterans' Affairs pharmacyViral load suppressionHAART usersNew HAARTRegimen typeInhibitor usersHIV infectionNonnucleoside reverseLow adherenceAdherence levelsPerfect adherenceVirtual cohortLogistic regressionDuration of timeAre two commonly used self-report questionnaires useful for identifying antihypertensive medication nonadherence?
Gallagher BD, Muntner P, Moise N, Lin JJ, Kronish IM. Are two commonly used self-report questionnaires useful for identifying antihypertensive medication nonadherence? Journal Of Hypertension 2015, 33: 1108-1113. PMID: 25909704, PMCID: PMC4500106, DOI: 10.1097/hjh.0000000000000503.Peer-Reviewed Original ResearchConceptsVisual analog scaleAntihypertensive medication nonadherenceUncontrolled hypertensionSelf-report questionnairesMedication nonadherenceGold standardMorisky Medication Adherence ScaleAntihypertensive medication regimenMedication Adherence ScalePrimary care visitsLikelihood ratioAntihypertensive medicationsCare visitsMedication regimenMMAS-8Adherence ScaleAnalog scaleLow adherenceHigh adherenceElectronic pillboxNonadherenceHypertensionSecond visitClinical settingSRQ scores
2014
Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease
Kim JJ, Lee JS, Olafsson S, Laine L. Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease. Helicobacter 2014, 19: 98-104. PMID: 24617668, DOI: 10.1111/hel.12114.Peer-Reviewed Original ResearchConceptsH. pylori testingProportion of patientsIndex hospitalizationHospitalized patientsConsecutive hospitalized patientsPeptic ulcer diseaseHelicobacter pylori testingInitial endoscopyUlcer diseaseSerologic testingSingle centerEndoscopy databaseSociety guidelinesGastric ulcerLow adherencePatientsUlcersMultivariate analysisHelicobacter pyloriHospitalizationDirect testingBiopsyTestingEndoscopyPylori
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