2021
TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
Xu S, Liu Y, Hu R, Wang M, Stöhr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps K, White M, Miao J. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. ELife 2021, 10: e57462. PMID: 34622775, PMCID: PMC8555985, DOI: 10.7554/elife.57462.Peer-Reviewed Original ResearchConceptsGluconeogenic gene promotersBinding of GRGene promoterGlucocorticoid receptorGlucose homeostasisLigand-binding domainGlucose productionOverexpression of TAZHepatic glucose homeostasisWW domainsBlood glucose concentrationPhysiological fastingGluconeogenic genesGR response elementResponse elementNovel roleTAZNormal physiological stateGR transactivationPhysiological statePromoterMouse liverPericentral hepatocytesPathological statesGlucose concentration
2016
GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
West D, Pan D, Tonsing-Carter E, Hernandez K, Pierce C, Styke S, Bowie K, Garcia T, Kocherginsky M, Conzen S. GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome. Molecular Cancer Research 2016, 14: 707-719. PMID: 27141101, PMCID: PMC5008962, DOI: 10.1158/1541-7786.mcr-15-0433.Peer-Reviewed Original ResearchConceptsCoactivator of GRBreast cancer outcomesChromatin associationGlucocorticoid receptorResponse elementBreast cancerEstrogen receptor (ER)-negative breast cancerER(+) breast cancer patientsCancer outcomesProximal promoter regionHigh-throughput sequencingER(+) breast cancer cellsExpression of differentiation genesEarly-stage breast cancerNuclear receptor functionGR-mediated transcriptional activityRelapse-free survivalAggressive natural historyAP1 response elementExpression of genesBreast cancer patientsWnt Signaling PathwayGR mRNA expressionBreast cancer cellsGR response element
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