2021
TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
Xu S, Liu Y, Hu R, Wang M, Stöhr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps K, White M, Miao J. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. ELife 2021, 10: e57462. PMID: 34622775, PMCID: PMC8555985, DOI: 10.7554/elife.57462.Peer-Reviewed Original ResearchConceptsGluconeogenic gene promotersBinding of GRGene promoterGlucocorticoid receptorGlucose homeostasisLigand-binding domainGlucose productionOverexpression of TAZHepatic glucose homeostasisWW domainsBlood glucose concentrationPhysiological fastingGluconeogenic genesGR response elementResponse elementNovel roleTAZNormal physiological stateGR transactivationPhysiological statePromoterMouse liverPericentral hepatocytesPathological statesGlucose concentration
1999
Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins
Hittelman A, Burakov D, Iñiguez‐Lluhí J, Freedman L, Garabedian M. Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins. The EMBO Journal 1999, 18: 5380-5388. PMID: 10508170, PMCID: PMC1171607, DOI: 10.1093/emboj/18.19.5380.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportGene Expression RegulationGlucocorticoidsHeLa CellsHumansNuclear ProteinsProtein BindingReceptors, GlucocorticoidTrans-ActivatorsTranscription FactorsTranscriptional ActivationTwo-Hybrid System TechniquesConceptsTranscriptional enhancementAF-1Regulatory factorsGlucocorticoid receptor transcriptional activationTumor susceptibility gene 101Two-hybrid approachTranscriptional regulatory factorsSusceptibility gene 101Activation functions AF-1AF-2Negative regulatory factorHormone-activated glucocorticoid receptorHormone-dependent mannerModified yeastTranscriptional activationMammalian cellsDRIP complexTarget genesProtein 150Differential regulationGlucocorticoid receptorGR transactivationTransactivationYeastGR ligands
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