2023
Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentBinge-Eating Disorder Interventions: Review, Current Status, and Implications
Grilo C, Juarascio A. Binge-Eating Disorder Interventions: Review, Current Status, and Implications. Current Obesity Reports 2023, 12: 406-416. PMID: 37439970, PMCID: PMC10528223, DOI: 10.1007/s13679-023-00517-0.Peer-Reviewed Original ResearchConceptsPsychological treatmentSpecific psychological treatmentsEating-disorder psychopathologyEvidence-based treatmentsAdditional pharmacological optionsDisorder interventionsSerious psychiatric problemsBehavioral lifestyle interventionScalable interventionsEffective interventionsFuture researchCBTPsychiatric problemsBingeMixed outcomesInterventionCBTgshModest weight lossRecent findingsResearchPsychopathologyShameLifestyle interventionPharmacological optionsSubstantial morbidity
2022
24‐Month follow‐up of randomized controlled trial of guided‐self‐help for loss‐of‐control eating after bariatric surgery
Grilo CM, Ivezaj V, Duffy AJ, Gueorguieva R. 24‐Month follow‐up of randomized controlled trial of guided‐self‐help for loss‐of‐control eating after bariatric surgery. International Journal Of Eating Disorders 2022, 55: 1521-1531. PMID: 36054766, DOI: 10.1002/eat.23804.Peer-Reviewed Original ResearchConceptsBariatric surgeryHELP treatmentWeight gainLong-term effectsSuboptimal long-term outcomesModest weight lossProportion of patientsBariatric surgery outcomesSubgroup of patientsLong-term outcomesSignificant weight gainSubstantial weight gainEating-disorder psychopathologyPostoperative interventionsAdjunctive treatmentTreat analysisSurgery outcomesSpecialist treatmentLOC eatingPatientsSurgeryWeight lossTrial testingPosttreatmentTreatmentAGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review
Long MT, Noureddin M, Lim JK. AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. Gastroenterology 2022, 163: 764-774.e1. PMID: 35842345, PMCID: PMC9398982, DOI: 10.1053/j.gastro.2022.06.023.Peer-Reviewed Original ResearchConceptsLean Nonalcoholic Fatty Liver DiseaseNonalcoholic fatty liver diseaseType 2 diabetes mellitusClinical Practice Updates CommitteeBiopsy-confirmed nonalcoholic steatohepatitisFatty liver diseaseBody mass indexDiabetes mellitusLean individualsLiver diseaseNonalcoholic steatohepatitisLean personsLiver cirrhosisMass indexHepatic steatosisNoninvasive testsManagement of NAFLDSodium-glucose cotransporter 2 inhibitorsGlucagon-like peptide-1 agonistsLysosomal acid lipase deficiencyPrognosis of NAFLDAGA Governing BoardLiver biochemical testsModest weight lossCotransporter 2 inhibitorsBenefits of weight loss of 10% or more in patients with overweight or obesity: A review
Tahrani AA, Morton J. Benefits of weight loss of 10% or more in patients with overweight or obesity: A review. Obesity 2022, 30: 802-840. PMID: 35333446, DOI: 10.1002/oby.23371.Peer-Reviewed Original ResearchConceptsObesity-related complicationsModest weight lossWeight lossBariatric surgeryLarge weight lossReduced cancer riskWeight-related complicationsCardiovascular risk factorsHealth-related qualityWeight management programType 2 diabetesGreater weight lossMain treatment targetsCost-effective interventionLifestyle modificationLifestyle interventionSevere obesityKnee osteoarthritisSleep apneaRisk factorsCancer riskGlucose metabolismPatientsOverweightTreatment targets
2021
Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth records
2020
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks
Perry RJ, Shulman GI. Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. Journal Of Biological Chemistry 2020, 295: 14379-14390. PMID: 32796035, PMCID: PMC7573269, DOI: 10.1074/jbc.rev120.008387.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSodium-glucose cotransporter 2SGLT2 inhibitorsEuglycemic ketoacidosisGlucose reabsorptionTherapeutic promiseSGLT2 inhibitor therapyLower plasma glucose concentrationsModest weight lossGlucose-lowering agentsRenal glucose reabsorptionType 2 diabetesType 1 diabetesPlasma glucose concentrationGlucose concentrationBlood glucose concentrationHeart failureInhibitor therapyAtrial fibrillationCardiovascular diseaseCotransporter 2Preclinical studiesHealthy personsClinical utilityDiabetes managementProximal tubules
2017
Alpha‐lipoic acid (ALA) as a supplementation for weight loss: results from a meta‐analysis of randomized controlled trials
Kucukgoncu S, Zhou E, Lucas K, Tek C. Alpha‐lipoic acid (ALA) as a supplementation for weight loss: results from a meta‐analysis of randomized controlled trials. Obesity Reviews 2017, 18: 594-601. PMID: 28295905, PMCID: PMC5523816, DOI: 10.1111/obr.12528.Peer-Reviewed Original ResearchConceptsAlpha-lipoic acidBody mass indexAlpha-lipoic acid treatmentPlacebo groupWeight lossEffect of ALASignificant short-term weight lossShort-term weight lossModest weight lossPlacebo treatment groupsPlacebo-controlled studyWeight changeAnti-obesity propertiesSystematic literature searchMeta-regression analysisMass indexSignificant morbidityALA doseBMI changeLong-term benefitsWeight managementBMI differencesTreatment groupsMortality rateStudy durationMental health and behavioral weight loss: 24-month outcomes in Veterans
Janney CA, Masheb RM, Lutes LD, Holleman RG, Kim HM, Gillon LR, Damschroder LJ, Richardson CR. Mental health and behavioral weight loss: 24-month outcomes in Veterans. Journal Of Affective Disorders 2017, 215: 197-204. PMID: 28340446, DOI: 10.1016/j.jad.2017.03.003.Peer-Reviewed Original ResearchConceptsBehavioral weight loss interventionSerious mental illnessWeight loss interventionMH diagnosisLoss interventionAffective disordersWeight lossModest weight lossOverweight/obeseBehavioral weight lossWeight loss trialMental health disordersAverage weight lossWeight loss differencesSecondary data analysisLoss trialThree-armHealth disordersWeight loss patternsLinear mixed effects modelsMental illnessDiagnostic groupsDiagnosisMental healthMonthsBehavioral Treatment for Veterans with Obesity: 24-Month Weight Outcomes from the ASPIRE-VA Small Changes Randomized Trial
Lutes LD, Damschroder LJ, Masheb R, Kim HM, Gillon L, Holleman RG, Goodrich DE, Lowery JC, Janney C, Kirsh S, Richardson CR. Behavioral Treatment for Veterans with Obesity: 24-Month Weight Outcomes from the ASPIRE-VA Small Changes Randomized Trial. Journal Of General Internal Medicine 2017, 32: 40-47. PMID: 28271430, PMCID: PMC5359162, DOI: 10.1007/s11606-017-3987-0.Peer-Reviewed Original ResearchConceptsWeight lossOverweight/obese veteransSignificant weight regainVeterans Affairs sitesModest weight lossWeight management programWeight management approachesGreater weight lossASPIRE groupObese veteransWeight regainWeight outcomesLifelong healthBehavioral treatmentDiabetesWeight changeCare movesTrialsObesitySignificant differencesSecond yearTreatmentVeteransAdditional yearSC supportPsychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Primary Endoscopic Treatments for Morbid Obesity
Schwartz J, Jalilvand A, Mikami D. Primary Endoscopic Treatments for Morbid Obesity. 2016, 429-443. DOI: 10.1007/978-3-319-24145-6_24.Peer-Reviewed Original ResearchMorbid obesityGastric bandingIntragastric balloonModulation therapyRestrictive proceduresWeight lossEndoBarrier Gastrointestinal LinerEndoscopic bariatric proceduresPrimary endoscopic treatmentExcess weight lossLaparoscopic sleeve gastrectomyModest weight lossAdjustable gastric bandingProximal small bowelEffective treatment optionCentral neural activityGastric electrical stimulationEarly device removalEarly satietyGastric bypassMalabsorptive proceduresSleeve gastrectomyBariatric proceduresBariatric treatmentComplication rate
2013
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder
Masheb RM, White MA, Grilo CM. Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. Comprehensive Psychiatry 2013, 54: 880-884. PMID: 23639407, PMCID: PMC3779527, DOI: 10.1016/j.comppsych.2013.03.017.Peer-Reviewed Original ResearchConceptsObese patientsBody weightWeight gainWeight gainersWeight lossHigh weight gainersLow weight gainersModest weight lossWeight changePercent of treatmentsFurther weight gainSubstantial weight gainObese BED patientsStabilization of weightTreatment-seeking obese patientsTreatment initiationSelf-report questionnairesBED patientsPatientsWeight trajectoriesCurrent weightTreatment studiesDisorder psychopathologyPercent weight gainMean gain
2012
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 8236-8240. PMID: 22547801, PMCID: PMC3361376, DOI: 10.1073/pnas.1205675109.Peer-Reviewed Original ResearchConceptsMuscle insulin resistanceInsulin-resistant offspringType 2 diabetesBranched-chain amino acidsInsulin resistanceIR offspringInsulin-stimulated muscle glucose uptakeWeight lossPeripheral insulin responsivenessReduction of IMCLModest weight lossPeripheral glucose metabolismC-reactive proteinHyperinsulinemic-euglycemic clampIntramyocellular lipid accumulationMuscle glucose uptakeAverage weight lossWeight reductionTotal adiponectinHypocaloric dietIL-6IMCL contentPlasma concentrationsWeight stabilizationIMCL accumulation
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